Results 1 to 10 of about 395,490 (100)

SG-APSIC1126: Controlling SARS-CoV-2 infection in inpatients through a grouping system at Ho Chi Minh Children’s Hospital 1 in Vietnam

Antimicrobial Stewardship & Healthcare Epidemiology, 2023
Objectives: At the onset of COVID-19, whenever SARS-CoV-2 was detected at Children’s Hospital 1 (CH1), the related department or building was closed for extensive tracing, testing, and medical isolation.
Chau Nguyen Ngoc Minh, Thi Thanh Thuy Le, Thanh Hung Nguye, Ngoc Quang Minh Ngo, Van Niem Do, Thi Thanh Huong Nguyen   +5 more
doaj   +1 more source

Protective effects of N-acetyl-l-cysteine against penconazole-triggered hepatorenal toxicity in adult rats

Journal of Veterinary Research, 2023
Penconazole (PEN) is a widely applied triazole fungicide. This study sought to define the efficacy of N-acetyl-l-cysteine (NAC) in mitigating PEN-triggered hepatorenal toxicity in rats.
Morgan Ashraf M., Ogaly Hanan A., Kamel Shaimaa, Rashad Maha M., Hassanen Eman I., Ibrahim Marwa A., Galal Mona K., Yassin Aya M., Dulmani Sharah A. Al, Al-Zahrani Fatimah A.M., Hussien Ahmed M.   +10 more
doaj   +1 more source

Protective Effects of Relaxin 2 (RLXH2) against Hypoxia-Induced Oxidative Damage and Cell Death via Activation of The Nrf2/HO-1 Signalling Pathway in Gastric Cancer Cells [PDF]

Cell Journal, 2023
Objective: This study aims to investigate the potential role of relaxin, a peptide hormone, in preventing cellulardeterioration and death in gastric carcinoma cells under hypoxic conditions.
Liguo Wang, Yi Zhou, Hui Lin, Kezhu Hou
doaj   +1 more source

Role of heme oxygenase-1 in tumor immune escape

Redox Experimental Medicine, 2023
The inducible enzyme heme oxygenase 1 (HO-1) plays a pivotal role in cell defense against different kind of stressors, from oxidative stress to hypoxia. For this reason, HO-1 overexpression has been correlated to cancer aggressiveness in different tumors,
Mariapaola Nitti, Jasmin Ortolan, Anna Lisa Furfaro   +2 more
doaj   +1 more source

ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte

Renal Failure, 2021
Aim Podocyte injury plays an important role in diabetic nephropathy (DN), yet the underlying molecular mechanisms of podocyte injury in DN is not clear.
Shizhu Yuan, Xudong Liang, Wenfang He, Mingzhu Liang, Juan Jin, Qiang He   +5 more
doaj   +1 more source

HO-1 in Bone Biology: Potential Therapeutic Strategies for Osteoporosis

Frontiers in Cell and Developmental Biology, 2021
Osteoporosis is a prevalent bone disorder characterized by bone mass reduction and deterioration of bone microarchitecture leading to bone fragility and fracture risk.
Xueman Zhou, Xueman Zhou, Wenxiu Yuan, Wenxiu Yuan, Xin Xiong, Zhenzhen Zhang, Zhenzhen Zhang, Jiaqi Liu, Jiaqi Liu, Yingcheng Zheng, Yingcheng Zheng, Jun Wang, Jin Liu   +12 more
doaj   +1 more source

Human Heme Oxygenase-1 Induced by Interleukin-6 via JAK/STAT3 Pathways Is a Tumor Suppressor Gene in Hepatoma Cells

Antioxidants, 2020
Heme oxygenase-1 (HO-1) has several important roles in hepatocytes in terms of anti-inflammation, anti-apoptosis, and antioxidant properties. Interleukin-6 (IL-6) is a pleiotropic cytokine associated with liver regeneration and protection against injury.
Kun-Chun Chiang, Kang-Shuo Chang, Shu-Yuan Hsu, Hsin-Ching Sung, Tsui-Hsia Feng, Mei Chao, Horng-Heng Juang   +6 more
doaj   +1 more source

Distinct Approaches of Raloxifene: Its Far-Reaching Beneficial Effects Implicating the HO-System

Biomolecules, 2020
Selective estrogen receptor modulators (SERMs) were discovered in the mid-1900s in connection with estrogen-related pathological conditions. They were developed to antagonize the adverse effects of estrogen and have been shown to be effective against ...
Denise Börzsei, Renáta Szabó, Alexandra Hoffmann, Médea Veszelka, Imre Pávó, Zsolt Turcsán, Csaba Viczián, Krisztina Kupai, Csaba Varga, Anikó Pósa   +9 more
doaj   +1 more source

Cerevisterol Alleviates Inflammation via Suppression of MAPK/NF-κB/AP-1 and Activation of the Nrf2/HO-1 Signaling Cascade

Biomolecules, 2020
As part of our continuous effort to find potential anti-inflammatory agents from endophytic fungi, a Fusarium solani strain, isolated from the plant Aponogeton undulatus Roxb., was investigated. Cerevisterol (CRVS) was identified from endophytic fungi, a
Md Badrul Alam, Nargis Sultana Chowdhury, Md Hossain Sohrab, Md Sohel Rana, Choudhury Mahmood Hasan, Sang-Han Lee   +5 more
doaj   +1 more source

Clinically confirmed DEL-1 as a myokine attenuates lipid-induced inflammation and insulin resistance in 3T3-L1 adipocytes via AMPK/HO-1- pathway

Adipocyte, 2020
Regular exercise is the first line of therapy for treating obesity-mediated metabolic disorders, including insulin resistance. It has been reported that developmental endothelial locus-1 (DEL-1) enhances macrophage efferocytosis, resulting in ...
Chang Hyuk Kwon, Jaw Long Sun, Myeong Jun Kim, A. M. Abd El-Aty, Ji Hoon Jeong, Tae Woo Jung   +5 more
doaj   +1 more source