Results 31 to 40 of about 22,040,645 (295)
Overexpression of Heme Oxygenase-1 Protects Dopaminergic Neurons against 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity [PDF]
, 2009 Heme oxygenase-1 (HO-1) is up-regulated in response to oxidative stress and catalyzes the degradation of pro- oxidant heme to carbon monoxide (CO) , iron, and bilirubin.
HUNG, SHIH-YA;LIOU, HOUNG-CHI;KANG, KAI -HSIANG;WU, RUEY-MEEI;WEN, CHUN-CHIANG;FU, WEN-MEI +1 more
core +1 more source
The prognostic and therapeutic potential of HO-1 in leukemia and MDS
Cell Communication and Signaling, 2023 Abstract Background Heme oxygenase-1 (HO-1), a heme-degrading enzyme, is proven to have anti-apoptotic effects in several malignancies. In addition, HO-1 is reported to cause chemoresistance and increase cell survival. Growing evidence indicates that HO-1 contributes to the course of hematological malignancies as well ...
Mohammad Sadeghi +8 more
openaire +3 more sources
HO-1 is rapidly increased after haptoglobin and hemopexin infusion. [PDF]
, 2018 (A and B) SS-mice (n = 3/group) were infused with vehicle or equimolar (1 μmol/kg) Hb, Hp, Hpx, Hb + Hp, or Hb + Hpx. Livers were removed and flash frozen 1 hour after infusion.
Gregory M. Vercellotti (190593) +12 more
core +1 more source
Biomolecules, 2020 Mevastatin (MVS) has been previously shown to induce heme oxygenase (HO)-1 expression through Nox/ROS-dependent PDGFRα/PI3K/Akt/Nrf2/ARE axis in human pulmonary alveolar epithelial cells (HPAEpiCs).
Chuen-Mao Yang +4 more
doaj +1 more source
The Modulatory Effect of Liraglutide on the Expression of GPX4, HO-1 and SLC7A11 Signaling Pathway in Obese Rats [PDF]
Pharmaceutical SciencesBackground: Obesity, a multifaceted metabolic condition, is associated with oxidative stress and disrupted redox homeostasis, leading to ferroptosis and metabolic dysfunction. Liraglutide, a well-known glucagon-like peptide-1 (GLP-1) receptor agonist, is
Mahmood Jameel Saeed, Inam Sameh Arif
doaj +1 more source
Molecular Genetics & Genomic Medicine, 2021 Background X‐linked hyper‐IgM syndrome (XHIGM) is a rare primary immunodeficiency caused by CD40 ligand defects. Methods We identified three patients with XHIGM in Ho Chi Minh City, Vietnam. Whole‐exome sequencing, immunological analyses and western blot
Anh Nguyen Lien Phan +14 more
doaj +1 more source
HO-1 expression in human prostate bone metastases. [PDF]
, 2016 (A) Representative sections of HO-1 staining (brown) in bone metastases, showing positive staining in tumor epithelial cells (patient 1), in tumor epithelial cells and in macrophages (patient 2), and in macrophages (patient 3) (200x magnifications).
Emma Jernberg (481248) +8 more
core +1 more source
HO-1 and CD39: It Takes Two to Protect the Realm [PDF]
Frontiers in Immunology, 2019 Cellular protective mechanisms exist to ensure survival of the cells and are a fundamental feature of all cells that is necessary for adapting to changes in the environment. Indeed, evolution has ensured that each cell is equipped with multiple overlapping families of genes that safeguard against pathogens, injury, stress, and dysfunctional metabolic ...
Ghee Rye Lee +2 more
openaire +3 more sources
HO-1 deficiency leads to poor bacterial clearance in vivo and in vitro. [PDF]
, 2017 Panel A: MRSA CFU levels in HO-1+/+ and HO-1-/- mice. HO-1+/+ and HO-1-/- mice infected intrapleurally with 5x106 CFU of MRSA were euthanized at indicated time points post infection.
Najmunnisa Nasreen (3615656) +4 more
core +1 more source
Role of HO‐1 in neuroblastoma resistance to Bortezomib
The FASEB Journal, 2013 Neuroblastoma (NB) is the most common solid tumor in childhood and is characterized by a poor prognosis due to the gain of a chemoresistant phenotype. Among the most recent anticancer therapies Bortezomib (BTZ) has shown impressive clinical activity to overcome cancer cell resistance to conventional therapy.
FURFARO, ANNA LISA +8 more
openaire +2 more sources