Results 11 to 20 of about 22,040,645 (295)

HO-1 overexpression and underexpression: Clinical implications [PDF]

Archives of Biochemistry and Biophysics, 2019
In this review we examine the effects of both over- and under-production of heme oxygenase-1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular disease. In a few instances e.g., neonatal jaundice, overproduction of HO-1 and increased HO activity results in elevated levels of bilirubin requiring clinical intervention with ...
George S, Drummond, Jeffrey, Baum, Menachem, Greenberg, David, Lewis, Nader G, Abraham   +4 more
openaire   +3 more sources

HO-1 Protects Remnant Liver against Dysfunction after Major Hepatectomy in Humans [PDF]

, 2021
During major resection of liver carcinoma, liver regeneration (LR) is induced by various clinical and biological factors. Heme oxygenase (HO)-1 has been found as a key inducer of LR in preclinical trial.
Xiaodong Jin (6029792), Zhenghui Hu (177961), Yan Zhang (8098), Xianwu Chen (5025428), Feifan Wang (1525195), Hongshen Wu (10038788), Shusen Zheng (187083), Ning He (384285), Xiuni Sun (11569219), Xuejian Zhou (10038782)   +9 more
core   +1 more source

Humanized HO-1 BAC transgenic mice: a new model for the study of HO-1 gene regulation [PDF]

Kidney International, 2012
Heme oxygenase-1 (HO-1) is a ubiquitous inducible stress-response enzyme that plays a central role in tissue homeostasis, in protection against oxidative stress, and in the pathogenesis of disease. Kim et al. report a novel transgenic mouse that lacks the endogenous HO-1 gene but contains the human HO-1 gene with all its regulatory elements.
Salom, Miguel G., Bonacasa, Bárbara
openaire   +2 more sources

Functional expression of human heme oxygenase-1 (HO-1) driven by HO-1 promoter in vitro and in vivo [PDF]

Journal of Cellular Biochemistry, 2002
AbstractWe developed a retrovirus‐mediated human heme oxygenase‐1 (HO‐1) gene expression system and assessed the impact of heme on the inducibility of the HO‐1 gene in rat lung microvessel (RLMV) endothelial cells and in newborn Sprague‐Dawley (SD) rats.
Shuo, Quan, Liming, Yang, Sylvia, Shenouda, Houli, Jiang, Michael, Balazy, Michal L, Schwartzman, Ichiyo, Shibahara, Kousei, Shinohara, Nader G, Abraham   +8 more
openaire   +2 more sources

Effect of vanillic acid on pentylenetetrazole-kindled rats: Nrf2/HO-1, IGF-1 signaling pathways cross talk [PDF]

Journal of Integrative Neuroscience, 2022
Vanillic acid (VA) exhibited antioxidant and neuroprotective properties in some neurodegenerative disorders. So, the current study examined the neuroprotective potential of VA as an antiepileptic agent in pentylenetetrazole (PTZ)-induced epileptic ...
Mahmoud A. El-Hefnawy, Asmaa Yehia, Eman M. El Nashar, Somaya Saad, Walaa Obydah, Mansour A. Alghamdi, Wardah A. Alasmari, Abdelaziz M. Hussein   +7 more
doaj   +1 more source

HO-1 in Control of a Self-Eating Kidney [PDF]

Journal of the American Society of Nephrology, 2010
Autophagy, from Greek meaning self-eating, refers to the degradation of macromolecules and organelles by the lysosomal machinery of cells and is a tightly regulated and normally occurring process that helps maintain a balance among synthesis, degradation, and recycling of cellular components.
Pinelopi P, Kapitsinou, Volker H, Haase
openaire   +2 more sources

HO-1 expression in macrophages. [PDF]

, 2016
Representative sections (400x magnifications) of rat prostate MatLyLu TINT double stained for CD68+ (brow) and HO-1+ (red) cells (A), or double stained for CD163+ (brown) and HO-1+ (red) cells (B).
Emma Jernberg (481248), Pernilla Wikström (175711), Elin Thysell (235940), Sofia Halin Bergström (755313), Maria Nilsson (40527), Hanibal Adamo (2826743), Pär Stattin (124323), Anders Bergh (175717), Anders Widmark (222869)   +8 more
core   +1 more source

HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children. [PDF]

, 2012
Heme oxygenase 1 (HO-1) is an essential enzyme induced by heme and multiple stimuli associated with critical illness. In humans, polymorphisms in the HMOX1 gene promoter may influence the magnitude of HO-1 expression.
Madi Njie (177625), Walther, Brigitte, Cunnington, A., De Caul, A, Sebastian Weis, Ebonyi, A., Deininger Susanne, Aka Peter, Deininger, S., Peter Aka, Takem, Ebako N, Predazzi, Irene M, Conway David J., Predazzi, IM, Cunnington, Aubrey, Walther, Michael, Conway, DJ, Aubrey Cunnington, Njie, M., Predazzi, I. M., Weis Sebastian, Augustine Ebonyi (177659), Sarah Rowland-Jones, Walther Michael, Amambua-Ngwa, A., Sarah Rowland-Jones (74678), Scott M. Williams (177668), Robert Walton, Susanne Deininger (173844), Sirugo, G, Cunnington Aubrey, Njie, Madi, Williams Scott M., Sirugo, Giorgio, Weis, S, Augustine Ebonyi, Walton Robert, Aka, P, Aka, P., Rowland-Jones Sarah, Williams, Scott M, Williams, S. M., Ebonyi, A, Alfred Amambua-Ngwa (122336), Weis, Sebastian, De Caul, Adam, Williams, SM, Sebastian Weis (161447), Amambua-Ngwa Alfred, Takem Ebako N., Deininger, Susanne, Adam De Caul (177612), Giorgio Sirugo, Ebako N. Takem (177656), Amambua-Ngwa, A, Walton, Robert T., Ebonyi, Augustine, Alfred Amambua-Ngwa, Madi Njie, Michael Walther, Rowland-Jones, S., Giorgio Sirugo (62489), Aka, Peter, Walton, R, Njie, M, De Caul Adam, Njie Madi, Rowland-Jones, Sarah, Takem, EN, Predazzi Irene M., Takem, E. N., Robert Walton (177664), Amambua-Ngwa, Alfred, Conway, D. J., Adam De Caul, Walther, B., Weis, S., Deininger, S, Susanne Deininger, Aubrey Cunnington (177640), Conway, David J, Peter Aka (177618), Sirugo, G., Ebako N Takem, David J Conway, David J. Conway (34880), de Caul, A., Irene M. Predazzi (177634), Brigitte Walther (130764), Walther, M, Walther, M., Walther Brigitte, Walton, Robert, Cunnington, A, Scott M Williams, Irene M Predazzi, Sirugo Giorgio, Walther, B, Rowland-Jones, S, Brigitte Walther, Michael Walther (130767), Ebonyi Augustine   +101 more
core   +1 more source

Effects of HO-1 overexpression on mitochondrial dysfunction and autophagy level in Lv-HO-1-H9c2 cells with H/R model. [PDF]

, 2016
(A) Cell viability was measured using the CCK-8 assay.
Yanlin Wang (110566), Yinwei Song (526878), Xianghu He (2637472), Dongling Chen (2637478), Linlin Jiang (2637475), Jianjuan Ke (2637481), Zhe Jin (43692), Jingjing Zhang (163589), Kai Chen (129938)   +8 more
core   +1 more source

Acacetin alleviates neuroinflammation and oxidative stress injury via the Nrf2/HO-1 pathway in a mouse model of spinal cord injury

Translational Neuroscience, 2022
Spinal cord injury (SCI) is a severe central nervous system disease, which may cause serious locomotor deficit. Acacetin is a flavone that possesses antioxidant and anti-inflammatory effects in different human diseases. The main purpose of this study was
Zhang Xin, Xu Lijun, Chen Xiang, Zhou Xianjie, Cao Lanhua   +4 more
doaj   +1 more source