Results 31 to 40 of about 197,106 (353)

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Molecular and Cellular Biology, 2020
The KEAP1-NRF2 pathway is the principal protective response to oxidative and electrophilic stresses. Under homeostatic conditions, KEAP1 forms part of an E3 ubiquitin ligase, which tightly regulates the activity of the transcription factor NRF2 by ...
Liam Baird, M. Yamamoto
semanticscholar   +1 more source

NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8

Science Advances, 2023
Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron homeostasis by controlling HERC2 (E3 ubiquitin ligase for NCOA4 and ...
A. Anandhan, M. Dodson, Aryatara Shakya, Jin-Jing Chen, Peng-Fei Liu, Yong-Yi Wei, H. Tan, Qian Wang, Zi-Yan Jiang, Kevin Yang, Joe G. N. Garcia, S. Chambers, E. Chapman, Aikseng Ooi, Yang Yang-Hartwich, B. Stockwell, Donna D. Zhang   +16 more
semanticscholar   +1 more source

Dangerous Entrapment for NRF2 [PDF]

Cell, 2016
Progerin, a mutated lamin A, causes the severe premature-aging syndrome Hutchinson-Gilford progeria (HGPS). Kubben et al. present a driving mechanism for HGPS involving trapping of NRF2 at the nuclear periphery by progerin. This local restriction results in impaired NRF2 signaling and chronic oxidative stress.
Vera, Gorbunova, Sarallah, Rezazadeh, Andrei, Seluanov   +2 more
openaire   +2 more sources

Monitoring Keap1-Nrf2 interactions in single live cells [PDF]

, 2014
The transcription factor NF-E2 p45-related factor 2 (Nrf2) and its negative regulator Kelch-like ECH associated protein 1 (Keap1) control the expression of nearly 500 genes with diverse cytoprotective functions.
Dinkova-Kostova, Albena, T, Baird, Liam, Llères, David, Swift, Sam, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T.   +5 more
core   +1 more source

Agmatine Mitigates Acetaminophen-induced Acute Liver Injury in Mice: Involvement of HMGB1/RAGE/NFκB and Nrf2/HO-1 Signaling Pathways [PDF]

Journal of Applied Veterinary Sciences
An overdose of acetaminophen (APAP) is considered one of the primary sources of drug-induced liver injury. This study aimed to explore the mechanism of agmatine (Agma) against APAP-induced acute liver injury (ALI) in mice.
Ahmed Abdelhady, Mohammed Ayman, Marwa Abdelmageed   +2 more
doaj   +1 more source

An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

Molecules, 2020
Inflammation is a key driver in many pathological conditions such as allergy, cancer, Alzheimer’s disease, and many others, and the current state of available drugs prompted researchers to explore new therapeutic targets.
S. Saha, B. Buttari, E. Panieri, E. Profumo, L. Saso   +4 more
semanticscholar   +1 more source

The emerging role of Nrf2 in mitochondrial function [PDF]

, 2015
The transcription factor NF-E2 p45-related factor 2 (Nrf2, gene name NFE2L2) allows adaptation and survival under conditions of stress by regulating the gene expression of diverse networks of cytoprotective proteins, including antioxidant, anti ...
Dinkova-Kostova, AT, Abramov, Andrey Y., Dinkova-Kostova, Albena T.; id_orcid, Abramov, AY, Dinkova-Kostova, Albena T.   +4 more
core   +1 more source

Study on the Mechanism of Rabdosia serra in the Treatment of Alcoholic Liver Injury Based on Network Pharmacology

Shipin gongye ke-ji, 2022
Objective: To investigate the protective effect and potential mechanism of Rabdosia serra on alcoholic liver injury. Method: Forty female Kunming mice were randomly divided into blank group, model group, Rabdosia serra group and positive control group ...
Wenbin LIU, Jingbin ZHONG, Hui WANG
doaj   +1 more source

The KEAP1-NRF2 pathway: Targets for therapy and role in cancer

Redox Biology, 2023
The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role in various disease pathologies has become well appreciated ...
S. Adinolfi, Tommi Patinen, Ashik Jawahar Deen, Sini Pitkänen, Jouni Härkönen, E. Kansanen, J. Küblbeck, A. Levonen   +7 more
semanticscholar   +1 more source

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents [PDF]

, 2014
The NRF2 signalling cascade provides a primary response against electrophilic chemicals and oxidative stress. The activation of NRF2-signaling is anticipated to have adverse clinical consequences; NRF2 is activated in a number of cancers, additionally ...
A Kenneth MacLeod, Lesley A McLaughlin, Henderson, Colin J., Kathryn H. Campbell (666563), McMahon, Michael, Michael McMahon, A. Kenneth MacLeod (666564), C Roland Wolf, Lesley A. McLaughlin (219228), MacLeod, A. Kenneth, C. Roland Wolf (293805), Kathryn H Campbell, Colin J Henderson, Michael McMahon (666562), Campbell, Kathryn H., McLaughlin, Lesley A., Colin J. Henderson (342321), Wolf, C. Roland   +17 more
core   +2 more sources