Results 31 to 40 of about 108,098 (261)

NRF2 molecule of the month [PDF]

Bioinformation, 2012
NRF2 – nuclear factor erythroid 2-related factor 2 is also known as GA binding protein transcription factor, alpha subunit 60kDa- GABPA [1, 2]. A recent literature review suggests that NRF2 has complex regulatory roles in cancer. NRF2 is a transcription factor and is upregulated by oncogenes.
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

OROPHARYNGEAL ADMINISTRATION OF POLYSTYRENE MICROPLASTICS INDUCES PROFIBROTIC AND OXIDATIVE CHANGES IN MURINE LUNG TISSUE

Проблеми екології та медицини
Aim: This study investigated the early pulmonary effects of intratracheally administered polystyrene microplastics (PS-MPs) in mice. Recognizing the emerging health concern of atmospheric microplastic inhalation, the research focused on identifying ...
Ye.V. Rybalchenko, A.V. Kabaliei, V.V. Palchyk, V.I. Shynkevych, I.P. Kaidashev   +4 more
doaj   +1 more source

Ethanol Impairs NRF2/Antioxidant and Growth Signaling in the Intact Placenta In Vivo and in Human Trophoblasts

Biomolecules, 2019
NRF2 is a redox-sensitive transcription factor that depending on the duration or magnitude of the stress, either translocates to the nucleus (beneficial) or is degraded in the cytosol (harmful). However, the role of NRF2-based mechanism(s) under ethanol (
Sambantham Shanmugam, Dhyanesh Patel, John M. Wolpert, Caezaan Keshvani, Xiaobo Liu, Susan E. Bergeson, Srivatsan Kidambi, Lenin Mahimainathan, George I. Henderson, Madhusudhanan Narasimhan   +9 more
doaj   +1 more source

Acacetin alleviates neuroinflammation and oxidative stress injury via the Nrf2/HO-1 pathway in a mouse model of spinal cord injury

Translational Neuroscience, 2022
Spinal cord injury (SCI) is a severe central nervous system disease, which may cause serious locomotor deficit. Acacetin is a flavone that possesses antioxidant and anti-inflammatory effects in different human diseases. The main purpose of this study was
Zhang Xin, Xu Lijun, Chen Xiang, Zhou Xianjie, Cao Lanhua   +4 more
doaj   +1 more source

Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway

Frontiers in Physiology, 2022
Ambient air temperature is a key factor affecting human health. Long-term exposure to a cold environment can cause various diseases, while the impact on the intestine, the organ which has the largest contact area with the external environment, cannot be ...
Jingru Guo, Huijie Hu, Zhuo Chen, Jing Xu, Junshu Nie, Jingjing Lu, Li Ma, Hong Ji, Jianbin Yuan, Bin Xu   +9 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Protective effect and mechanism of alpha-lipoic acid on lead-induced Sertoli cell damage in rooster testes

Asian Pacific Journal of Reproduction
Objective: To investigate the protective effect of alpha-lipoic acid on lead-induced Sertoli cell injury and its potential molecular mechanisms using primary Sertoli cells from rooster testes. Methods: Primary Sertoli cells from 6-week-old rooster testes
Junrong Li, Shanli Zhu, Nanwei Ye, Fangxiong Shi   +3 more
doaj   +1 more source

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Molecules, 2019
There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the isothiocyanate sulforaphane.
Yoko Yagishita, Jed W. Fahey, Albena T. Dinkova-Kostova, Thomas W. Kensler   +3 more
doaj   +1 more source