Quantitative analysis of NRF2 pathway reveals key elements of the regulatory circuits underlying antioxidant response and proliferation of ovarian cancer cells [PDF]
, 2014 Cells are constantly exposed to Reactive Oxygen Species (ROS) produced both endogenously to meet physiological requirements and from exogenous sources.
Bown, James +5 more
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NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland [PDF]
, 2018 Background: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation ...
Amendola, Elena +19 more
core +1 more source
Transcriptional Regulation by Nrf2
Antioxidants & Redox Signaling, 2018 Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes. Understanding the regulation of Nrf2 activity and downstream pathways has major implications for human health.
Tonelli, C. +2 more
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Opposing effects of Nrf2 and Nrf2‐activating compounds on the NLRP3 inflammasome independent of Nrf2‐mediated gene expression [PDF]
European Journal of Immunology, 2017 The transcription factor Nrf2 regulates the expression of genes required for protection from xenobiotic and oxidative stress. Under normal conditions Nrf2 is constantly degraded upon ubiquitination, mediated by the Nrf2 inhibitor Keap1. Inflammasomes represent stress‐induced protein complexes.
Garstkiewicz, Martha +7 more
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Argon protects against hypoxic-ischemic brain injury in neonatal rats through activation of Nuclear factor (erythroid-derived 2)-like 2 [PDF]
, 2016 Perinatal hypoxic ischaemic encephalopathy (HIE) has a high mortality rate with neuropsychological impairment. This study investigated the neuroprotective effects of argon against neonatal hypoxic-ischaemic brain injury.
Ciechanowicz, S +6 more
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Journal of Integrative Neuroscience, 2023 Background: Apigenin has been reported to exhibit anti-inflammatory and anti-oxidative activities. This study aimed to investigate the protective role of Apigenin on chemotherapy-induced peripheral neuropathy (CIPN).
Wenji Xie +4 more
doaj +1 more source
Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis. [PDF]
, 2013 Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no effective treatment to date. Despite its multi-factorial aetiology, oxidative stress is hypothesized to be one of the key pathogenic mechanisms.
Azzouz, M +6 more
core +1 more source
Cell StressDifferential and even opposing functions of two major antioxidant transcription factors Nrf1 and Nrf2 (encoded by Nfe2l1 and Nfe2l2, respectively) are determined by distinctions in their tempospatial positioning, topological repartitioning, proteolytic ...
Yiguo Zhang +8 more
doaj +1 more source
Translational Neuroscience, 2022 Parkinson’s disease (PD) is a common neurodegenerative disease that severely affects the quality of life of patients. There is no specific drug for PD up to now.
Huang Lijuan +4 more
doaj +1 more source
Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction
Medicinal Chemistry Research, 2020 Activation of the transcription factor Nrf2 via the Keap1-Nrf2-ARE signaling system regulates the transcription and subsequent expression of cellular cytoprotective proteins and plays a crucial role in preventing pathological conditions exacerbated by the overproduction of oxidative stress.
Sumi Lee, Longqin Hu
openaire +3 more sources