Results 31 to 40 of about 157,133 (211)
An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation
Molecules, 2020 Inflammation is a key driver in many pathological conditions such as allergy, cancer, Alzheimer’s disease, and many others, and the current state of available drugs prompted researchers to explore new therapeutic targets.
S. Saha +4 more
semanticscholar +1 more source
Carvacrol Ameliorating Effects on Trimethyltin Chloride-Induced Neurotoxicity by Modulating the Interplay between Nrf2/Keap1/ARE Pathway and Sirt1 [PDF]
Research Journal of Pharmacognosy, 2022 Background and objectives: Trimethyltin chloride (TMT) is a chemical with neurotoxic effects on central nervous system. Carvacrol is a phenolic monoterpenoid with antioxidative properties derived from oregano, thyme, and other plants. We aimed to explore
Farzaneh Babak +3 more
doaj +1 more source
Dangerous Entrapment for NRF2 [PDF]
Cell, 2016 Progerin, a mutated lamin A, causes the severe premature-aging syndrome Hutchinson-Gilford progeria (HGPS). Kubben et al. present a driving mechanism for HGPS involving trapping of NRF2 at the nuclear periphery by progerin. This local restriction results in impaired NRF2 signaling and chronic oxidative stress.
Vera, Gorbunova +2 more
openaire +2 more sources
Advances and challenges in therapeutic targeting of NRF2.
TIPS - Trends in Pharmacological Sciences, 2023 Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation, and metabolic imbalances.
A. Dinkova-Kostova, I. Copple
semanticscholar +1 more source
Nrf2 Signaling in Macrophages [PDF]
Reactive Oxygen Species, 2016 The nuclear factor E2-related factor 2 (Nrf2) is known as the chief regulator of cellular antioxidant defenses as well as a suppressor of inflammation. Macrophages act as major players in inflammatory responses. Because oxidative stress and inflammation are two intertwined processes, the anti-inflammatory activity of Nrf2 signaling is believed to ...
Hong, Zhu, Zhenquan, Jia, Y Robert, Li
openaire +2 more sources
COPD lung studies of Nrf2 expression and the effects of Nrf2 activators
Inflammopharmacology, 2022 Abstract Background Nrf2 regulates cellular antioxidant defence in lung cells, including epithelial cells and alveolar macrophages (AM). The Nrf2/Keap-1 pathway can be modulated by activators with different modes of action; electrophilic compounds and protein–protein interaction (PPI) inhibitors.
Jian Li +10 more
openaire +2 more sources
NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
Redox Biology, 2019 The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of the cellular antioxidant response, controlling the expression of genes that counteract oxidative and electrophilic stresses.
M. Dodson +2 more
semanticscholar +1 more source
Frontiers in Immunology, 2022 Macrophages are the most abundant immune cells within the synovial joints, and also the main innate immune effector cells triggering the initial inflammatory responses in the pathological process of osteoarthritis (OA).
Lin Wang, Chengqi He
semanticscholar +1 more source
Pharmaceutical Biology, 2021 Context Previous studies indicate that compound Danshen Dripping Pill (CDDP) improves the adaptation to high-altitude exposure. However, its mechanism of action is not clear.
Yunhui Hu +8 more
doaj +1 more source
Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity
Frontiers in Cell and Developmental Biology, 2022 Nrf2 and NF-κB are important regulators of the response to oxidative stress and inflammation in the body. Previous pharmacological and genetic studies have confirmed crosstalk between the two.
Wen Gao +7 more
semanticscholar +1 more source