Results 1 to 10 of about 45,202 (305)
Cell Reports, 2023 Summary: NRF2 (nuclear factor erythroid 2-related factor 2) is a master regulator of protective responses in healthy tissues. However, when it is active in tumor cells, it can result in drug resistance.
Gerald Batist +2 more
exaly +4 more sources
Inter-domain distance analysis reveals conformational changes in the Keap1-Nrf2 stress sensor system [PDF]
Redox BiologyThe Keap1-Nrf2 system plays a central role in cellular defense against oxidative stress. Structural information on full-length Keap1 is essential for understanding the molecular basis of this regulation.
Ritsumi Saito +11 more
doaj +2 more sources
Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1
Cell Reports, 2019 Summary: The Keap1-Nrf2 system plays a central role in the oxidative stress response; however, the identity of the reactive oxygen species sensor within Keap1 remains poorly understood.
Takao Iwawaki +2 more
exaly +3 more sources
Carvacrol Ameliorating Effects on Trimethyltin Chloride-Induced Neurotoxicity by Modulating the Interplay between Nrf2/Keap1/ARE Pathway and Sirt1 [PDF]
Research Journal of Pharmacognosy, 2022 Background and objectives: Trimethyltin chloride (TMT) is a chemical with neurotoxic effects on central nervous system. Carvacrol is a phenolic monoterpenoid with antioxidative properties derived from oregano, thyme, and other plants. We aimed to explore
Farzaneh Babak +3 more
doaj +1 more source
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease [PDF]
Open Biology, 2020 Redox imbalance and persistent inflammation are the underlying causes of most chronic diseases. Mammalian cells have evolved elaborate mechanisms for restoring redox homeostasis and resolving acute inflammatory responses.
Sharadha Dayalan Naidu +1 more
doaj +1 more source
OncoImmunology, 2021 Somatic mutations of STK11 or KEAP1 are associated with poor clinical outcomes for advanced non-small-cell lung cancer (aNSCLC) patients receiving immune checkpoint inhibitors (ICIs), chemotherapy, or targeted therapy.
Wei Nie +19 more
doaj +1 more source
Journal of Experimental Life Science, 2020 Aging is caused by an imbalance between antioxidants and ROS. Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates antioxidant genes. Under normal conditions, Nrf2 will bind keap1 and cause degradation of Nrf2. Nrf2
Viona Faiqoh Hikmawati +3 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Chronic obstructive pulmonary disease (COPD) is a severely disabling chronic lung disease characterized by persistent airway inflammation, which leads to limited expiratory airflow that deteriorates over time.
Yifan Xu +10 more
doaj +1 more source
p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control
Molecular & Cellular Oncology, 2021 Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear ...
Eeva-Liisa Eskelinen +2 more
doaj +1 more source
Redox Report, 2021 Background Progression of Benign Prostate hyperplasia (BPH) is vulnerable to oxidative stress (OS) and prostatic enlargement among the aging males through apoptosis deregulation.
Nabila Jahan +5 more
doaj +1 more source