Results 1 to 10 of about 50,990 (303)
Cell Reports, 2023 Summary: NRF2 (nuclear factor erythroid 2-related factor 2) is a master regulator of protective responses in healthy tissues. However, when it is active in tumor cells, it can result in drug resistance.
Tahar Aboulkassim +2 more
exaly +4 more sources
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
Molecular and Cellular Biology, 2020 The KEAP1-NRF2 pathway is the principal protective response to oxidative and electrophilic stresses. Under homeostatic conditions, KEAP1 forms part of an E3 ubiquitin ligase, which tightly regulates the activity of the transcription factor NRF2 by ...
Liam Baird, Masayuki Yamamoto
exaly +2 more sources
Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway
Redox Biology, 2022 The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical pathway has been extensively studied and reviewed in the past two decades, but rarely ...
Jingbo Pi, Qiang Zhang
exaly +2 more sources
PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development
Cell, 2023 SUMMARY Selective clearance of organelles, including endoplasmic reticulum (ER) and mitochondria, by autophagy plays an important role in cell health. Here we describe a developmentally programmed selective ER clearance by autophagy.
Ruoxi Wang +2 more
exaly +2 more sources
Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1
Cell Reports, 2019 Summary: The Keap1-Nrf2 system plays a central role in the oxidative stress response; however, the identity of the reactive oxygen species sensor within Keap1 remains poorly understood.
Takafumi Suzuki +2 more
exaly +3 more sources
Carvacrol Ameliorating Effects on Trimethyltin Chloride-Induced Neurotoxicity by Modulating the Interplay between Nrf2/Keap1/ARE Pathway and Sirt1 [PDF]
Research Journal of Pharmacognosy, 2022 Background and objectives: Trimethyltin chloride (TMT) is a chemical with neurotoxic effects on central nervous system. Carvacrol is a phenolic monoterpenoid with antioxidative properties derived from oregano, thyme, and other plants. We aimed to explore
Farzaneh Babak +3 more
doaj +1 more source
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease [PDF]
Open Biology, 2020 Redox imbalance and persistent inflammation are the underlying causes of most chronic diseases. Mammalian cells have evolved elaborate mechanisms for restoring redox homeostasis and resolving acute inflammatory responses.
Sharadha Dayalan Naidu +1 more
doaj +1 more source
OncoImmunology, 2021 Somatic mutations of STK11 or KEAP1 are associated with poor clinical outcomes for advanced non-small-cell lung cancer (aNSCLC) patients receiving immune checkpoint inhibitors (ICIs), chemotherapy, or targeted therapy.
Wei Nie +19 more
doaj +1 more source
The KEAP1-NRF2 pathway: Targets for therapy and role in cancer
Redox Biology, 2023 The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role in various disease pathologies has become well appreciated ...
S. Adinolfi +7 more
semanticscholar +1 more source
Journal of Experimental Life Science, 2020 Aging is caused by an imbalance between antioxidants and ROS. Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates antioxidant genes. Under normal conditions, Nrf2 will bind keap1 and cause degradation of Nrf2. Nrf2
Viona Faiqoh Hikmawati +3 more
doaj +1 more source