Results 1 to 10 of about 53,484 (262)
A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling [PDF]
Nature, 2018 Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of ...
Michael J Bollong +2 more
exaly +4 more sources
KEAP1 mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancer [PDF]
Frontiers in OncologyThe KEAP1/NRF2 pathway, a major regulator of the cellular oxidative stress response, is frequently activated in human cancers. Often mediated by loss-of-function mutations in KEAP1, this activation causes increased NRF2 transcriptional activity and ...
Nicholas E. Bambach +8 more
doaj +2 more sources
Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1
Cell Reports, 2019 Summary: The Keap1-Nrf2 system plays a central role in the oxidative stress response; however, the identity of the reactive oxygen species sensor within Keap1 remains poorly understood.
Takafumi Suzuki +2 more
exaly +3 more sources
Carvacrol Ameliorating Effects on Trimethyltin Chloride-Induced Neurotoxicity by Modulating the Interplay between Nrf2/Keap1/ARE Pathway and Sirt1 [PDF]
Research Journal of Pharmacognosy, 2022 Background and objectives: Trimethyltin chloride (TMT) is a chemical with neurotoxic effects on central nervous system. Carvacrol is a phenolic monoterpenoid with antioxidative properties derived from oregano, thyme, and other plants. We aimed to explore
Farzaneh Babak +3 more
doaj +1 more source
OncoImmunology, 2021 Somatic mutations of STK11 or KEAP1 are associated with poor clinical outcomes for advanced non-small-cell lung cancer (aNSCLC) patients receiving immune checkpoint inhibitors (ICIs), chemotherapy, or targeted therapy.
Wei Nie +19 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Chronic obstructive pulmonary disease (COPD) is a severely disabling chronic lung disease characterized by persistent airway inflammation, which leads to limited expiratory airflow that deteriorates over time.
Yifan Xu +10 more
doaj +1 more source
Roles of autophagy and p62 /SQSTM1 in hepatic ischemia-reperfusion
生物医学转化, 2021 Autophagy is a lysosomal dependent degradation system, and p62 itself is an importantprotein carrier to facilitate the removal of damaged proteins by proteasomes and autophagosomes. p62 playsan important role in selective autophagy such as mitochondrial
Zhang Haiming, Zhu Zhijun
doaj +1 more source
Journal of Experimental Life Science, 2020 Aging is caused by an imbalance between antioxidants and ROS. Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates antioxidant genes. Under normal conditions, Nrf2 will bind keap1 and cause degradation of Nrf2. Nrf2
Viona Faiqoh Hikmawati +3 more
doaj +1 more source
Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone [PDF]
, 2020 Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1.
Boothman, David A. +6 more
core +1 more source
Antioxidants, 2022 NF-E2-related factor 2 (NRF2), an antioxidant transcription factor, is activated in autophagy-deficient mice due to the accumulations of p62/SQSTM1 and its subsequent interaction with Kelch-like-ECH-associated protein 1 (KEAP1), an adaptor component for ...
Eun Young Kim, Jae Man Lee
doaj +1 more source