Results 21 to 30 of about 35,325 (217)

Antioxidant and renal protective effects of Nano-selenium on adenine-induced acute renal failure in canines

Ecotoxicology and Environmental Safety
Acute renal failure is a common clinical disease in canines, affecting antioxidant levels and decreasing the body's resistance. This study aims to explore the therapeutic mechanism of Nano-selenium in acute renal failure.
Mengdi Zhang, Jindong Gao, Md. F. Kulyar, Wanhe Luo, Guodong Zhang, Xiaoqi Yang, Tianguang Zhang, Haihang Gao, Yuxuan Peng, Jiabin Zhang, Muhammad Altaf, Samah Attia Algharib, Donghai Zhou, Jianzhong He   +13 more
doaj   +1 more source

Protective Effect of Astaxanthin on Ochratoxin A-Induced Kidney Injury to Mice by Regulating Oxidative Stress-Related NRF2/KEAP1 Pathway

Molecules, 2020
The present study aimed to investigate the effects of astaxanthin (ASX) on ochratoxin A (OTA)-induced renal oxidative stress and its mechanism of action.
Lin Li, Yueli Chen, Danyang Jiao, Shuhua Yang, Lin Li, Peng Li   +5 more
doaj   +1 more source

NQO1 Enzyme and its Role in Cellular Protection; an Insight

Iberoamerican Journal of Medicine, 2020
NAD(P)H:quinone oxidoreductase 1 (NQO1) is considered as one of the most significant enzyme in cellular defense due to its ability to detoxify reactive quinones and quinone imines to their less toxic hydroquinones forms. NQO1 is a xenobiotic metabolizing
Ahmed Atia, Azman Abdullah
doaj   +1 more source

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

Biomolecules, 2020
Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various ...
Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura, Ken Itoh   +4 more
doaj   +1 more source

Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue

Frontiers in Aging Neuroscience, 2021
The Keap1-Nrf2 signaling axis is a validated and promising target for cellular defense and survival pathways. This minireview discusses the potential off-target effects and their impact on future drug development originating from Keap1-targeting small ...
Dmitry M. Hushpulian, Dmitry M. Hushpulian, Navneet Ammal Kaidery, Navneet Ammal Kaidery, Manuj Ahuja, Manuj Ahuja, Manuj Ahuja, Andrey A. Poloznikov, Sudarshana M. Sharma, Irina G. Gazaryan, Irina G. Gazaryan, Irina G. Gazaryan, Irina G. Gazaryan, Bobby Thomas, Bobby Thomas, Bobby Thomas, Bobby Thomas   +16 more
doaj   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Agmatine Mitigates Acetaminophen-induced Acute Liver Injury in Mice: Involvement of HMGB1/RAGE/NFκB and Nrf2/HO-1 Signaling Pathways [PDF]

Journal of Applied Veterinary Sciences
An overdose of acetaminophen (APAP) is considered one of the primary sources of drug-induced liver injury. This study aimed to explore the mechanism of agmatine (Agma) against APAP-induced acute liver injury (ALI) in mice.
Ahmed Abdelhady, Mohammed Ayman, Marwa Abdelmageed   +2 more
doaj   +1 more source

Cloning and expression analysis of Keap1 of golden pompano (Trachinotus ovatus) and response to oxidized fish oil and LPS administration

Aquaculture Reports, 2020
Keap1 is an important component of Nrf2-Keap1 signaling pathways. However, information about Keap1 in T. ovatus is quiet limit. Thus, the full length of Keap1 was cloned from T. ovatus in this study.
Jiajun Xie, Xu Chen, Xuanshu He, Jin Niu
doaj   +1 more source

Keap1 recognizes EIAV early accessory protein Rev to promote antiviral defense.

PLoS Pathogens, 2022
The Nrf2/Keap1 axis plays a complex role in viral susceptibility, virus-associated inflammation and immune regulation in host cells. However, whether or how the Nrf2/Keap1 axis is involved in the interactions between equine lentiviruses and their hosts ...
Yan Wang, Guanqin Ma, Xue-Feng Wang, Lei Na, Xing Guo, Jiaqi Zhang, Cong Liu, Cheng Du, Ting Qi, Yuezhi Lin, Xiaojun Wang   +10 more
doaj   +1 more source

The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2

iScience, 2022
Summary: Transcription factor Nrf2 and its negative regulator Keap1 orchestrate a cytoprotective response against oxidative, metabolic, and inflammatory stress. Keap1 is a drug target, with several small molecules in drug development.
Sharadha Dayalan Naidu, Takafumi Suzuki, Dina Dikovskaya, Elena V. Knatko, Maureen Higgins, Miu Sato, Miroslav Novak, José A. Villegas, Terry W. Moore, Masayuki Yamamoto, Albena T. Dinkova-Kostova   +10 more
doaj   +1 more source