Keap1–Nrf2 signalling in pancreatic cancer [PDF]
The International Journal of Biochemistry & Cell Biology, 2015 Transcription factor NF-E2 p45-related factor 2 (Nrf2, also called Nfe2l2), a master regulator of redox homeostasis, and its dominant negative regulator, Kelch-like ECH-associated protein 1 (Keap1), together tightly control the expression of numerous detoxifying and antioxidant genes.
Hayes, Alastair J +3 more
openaire +3 more sources
KEAP1/NRF2 as a druggable target [PDF]
Arhiv za farmaciju, 2023 Nuclear factor erythroid 2-related factor 2 (NRF2; encoded by NFE2L2) is an inducible transcription factor that regulates the expression of a large network of genes encoding proteins with cytoprotective functions.
Dinkova-Kostova Albena T.
doaj
p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control
Molecular & Cellular Oncology, 2021 Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear ...
Eeva-Liisa Eskelinen +2 more
doaj +1 more source
Quantitative analysis of NRF2 pathway reveals key elements of the regulatory circuits underlying antioxidant response and proliferation of ovarian cancer cells [PDF]
, 2014 Cells are constantly exposed to Reactive Oxygen Species (ROS) produced both endogenously to meet physiological requirements and from exogenous sources.
Bown, James +5 more
core +4 more sources
Redox Report, 2021 Background Progression of Benign Prostate hyperplasia (BPH) is vulnerable to oxidative stress (OS) and prostatic enlargement among the aging males through apoptosis deregulation.
Nabila Jahan +5 more
doaj +1 more source
Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]
, 2019 Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y. +3 more
core +3 more sources
Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy [PDF]
, 2017 Mitophagy orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological accumulation and contributing to cellular homeostasis.
A Jain +53 more
core +3 more sources
NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland [PDF]
, 2018 Background: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation ...
Amendola, Elena +19 more
core +1 more source
A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90
Disease Models & Mechanisms, 2022 Nrf2 is the master transcriptional regulator of cellular responses against oxidative stress. It is chiefly regulated by Keap1, a substrate adaptor protein that mediates Nrf2 degradation. Nrf2 activity is also influenced by many other protein interactions
Vy Ngo +5 more
doaj +1 more source
NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival [PDF]
, 2014 Transcription factor NRF2 is an important regulator of oxidative stress. It is involved in cancer progression, and has abnormal constitutive expression in acute myeloid leukaemia (AML).
A Ooi +46 more
core +1 more source