Results 21 to 30 of about 45,202 (305)

miR-141-3p accelerates ovarian cancer progression and promotes M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway

Open Medicine, 2023
The miR-141-3p has been reported to participate in regulating autophagy and tumor-stroma interactions in ovarian cancer (OC). We aim to investigate whether miR-141-3p accelerates the progression of OC and its effect on macrophage 2 polarization by ...
Zhao Jingyun, Liu Leilei, Zhao Wei, Lv Cuiting, Zhang Na, Jia Xinzhuan, Zhang Zhengmao   +6 more
doaj   +1 more source

Keap1 inhibition attenuates glomerulosclerosis [PDF]

Nephrology Dialysis Transplantation, 2014
NFE2-related factor 2 (Nrf2) is a master regulatory transcription factor for antioxidant genes. Inhibition of its adaptor protein, Kelch-like ECH-associated protein 1 (Keap1), activates Nrf2. Podocyte injury triggers the progressive deterioration of glomerular damage toward glomerulosclerosis. We examined whether modulation of the Keap1-Nrf2 system has
Yoichi, Miyazaki, Akihiro, Shimizu, Ira, Pastan, Keiko, Taguchi, Eriko, Naganuma, Takafumi, Suzuki, Tatsuo, Hosoya, Takashi, Yokoo, Akihiko, Saito, Toshio, Miyata, Masayuki, Yamamoto, Taiji, Matsusaka   +11 more
openaire   +2 more sources

Monitoring Keap1-Nrf2 interactions in single live cells [PDF]

, 2014
The transcription factor NF-E2 p45-related factor 2 (Nrf2) and its negative regulator Kelch-like ECH associated protein 1 (Keap1) control the expression of nearly 500 genes with diverse cytoprotective functions.
Dinkova-Kostova, Albena, T, Baird, Liam, Llères, David, Swift, Sam, Dinkova-Kostova, Albena T.; id_orcid   +4 more
core   +1 more source

Nrf2 regulates ROS production by mitochondria and NADPH oxidase. [PDF]

, 2015
Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like ECH associated protein 1 (Keap1) thereby providing inducible antioxidant ...
Dinkova-Kostova, AT, Holmström, Kira M., Stjepana Kovaca, Kovac, S, Plamena R. Angelovaa, Ying Zhangb, Andrey Y. Abramova, Abramov, Andrey Y., Angelova, PR, Zhang, Y, Abramov, AY, Angelova, Plamena R., Kovac, Stjepana, Zhang, Ying, Kira M. Holmströma, Holmström, KM, Dinkova-Kostova, Albena T.; id_orcid, Albena T   +17 more
core   +1 more source

Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals [PDF]

Antioxidants, 2020
Epigenetics has provided a new dimension to our understanding of nuclear factor erythroid 2–related factor 2/Kelch-like ECH-associated protein 1 (human NRF2/KEAP1 and murine Nrf2/Keap1) signaling. Unlike the genetic changes affecting DNA sequence, the reversible nature of epigenetic alterations provides an attractive avenue for cancer interception ...
Shamee Bhattacharjee, Roderick H. Dashwood   +1 more
openaire   +3 more sources

A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90

Disease Models & Mechanisms, 2022
Nrf2 is the master transcriptional regulator of cellular responses against oxidative stress. It is chiefly regulated by Keap1, a substrate adaptor protein that mediates Nrf2 degradation. Nrf2 activity is also influenced by many other protein interactions
Vy Ngo, Anne Brickenden, Hansen Liu, Cynthia Yeung, Wing-Yiu Choy, Martin L. Duennwald   +5 more
doaj   +1 more source

Protective effects of N-acetyl-l-cysteine against penconazole-triggered hepatorenal toxicity in adult rats

Journal of Veterinary Research, 2023
Penconazole (PEN) is a widely applied triazole fungicide. This study sought to define the efficacy of N-acetyl-l-cysteine (NAC) in mitigating PEN-triggered hepatorenal toxicity in rats.
Morgan Ashraf M., Ogaly Hanan A., Kamel Shaimaa, Rashad Maha M., Hassanen Eman I., Ibrahim Marwa A., Galal Mona K., Yassin Aya M., Dulmani Sharah A. Al, Al-Zahrani Fatimah A.M., Hussien Ahmed M.   +10 more
doaj   +1 more source

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases. [PDF]

, 2013
Cullin-RING ligases are multisubunit E3 ubiquitin ligases that recruit substrate-specific adaptors to catalyze protein ubiquitylation. Cul3-based Cullin-RING ligases are uniquely associated with BTB adaptors that incorporate homodimerization, Cul3 ...
Canning, P, Marsden, BD, Gileadi, Opher, Krojer, Tobias, Pike, AC, Hojzan, V, Thangaratnarajah, C, Murray, James W., Cooper, CD, Keates, Tracy, Thangaratnarajah, Chancievan, Bullock, Alex N., Knapp, Stefan, Marsden, Brian D., Hojzan, Viktorija, Murray, JW, von Delft, Frank, Chaikuad, A, Keates, T, Ayinampudi, Vikram, Ayinampudi, V, Pike, Ashley C.W., Chaikuad, Apirat, Krojer, T, Canning, Peter, Cooper, Christopher D.O., Bullock, Alexander, von Delft, Frank (author), Gileadi, Opher (author), Hojzan, Viktorija (author), Bullock, Alex N. (author), Canning, Peter (author), Marsden, Brian D. (author), Knapp, Stefan (author), Keates, Tracy (author), Cooper, Christopher D.O. (author), Thangaratnarajah, Chancievan (author), Pike, Ashley C.W. (author), Krojer, Tobias (author), Chaikuad, Apirat (author), Murray, James W. (author)   +40 more
core   +1 more source

Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease

FASEB BioAdvances, 2019
Bicaudal D1 (BICD1), an adaptor for the dynein‐dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD).
Nicolas Mercado, Thomas Colley, Jonathan R. Baker, Chaitanya Vuppussetty, Yuta Kono, Colin Clarke, Sharon Tooze, Terje Johansen, Peter J. Barnes   +8 more
doaj   +1 more source

KEAP1/NRF2 as a druggable target [PDF]

Arhiv za farmaciju, 2023
Nuclear factor erythroid 2-related factor 2 (NRF2; encoded by NFE2L2) is an inducible transcription factor that regulates the expression of a large network of genes encoding proteins with cytoprotective functions.
Dinkova-Kostova Albena T.
doaj