Results 21 to 30 of about 50,990 (303)

NRF2 Activation in Autophagy Defects Suppresses a Pharmacological Transactivation of the Nuclear Receptor FXR

Antioxidants, 2022
NF-E2-related factor 2 (NRF2), an antioxidant transcription factor, is activated in autophagy-deficient mice due to the accumulations of p62/SQSTM1 and its subsequent interaction with Kelch-like-ECH-associated protein 1 (KEAP1), an adaptor component for ...
Eun Young Kim, Jae Man Lee
doaj   +1 more source

miR-141-3p accelerates ovarian cancer progression and promotes M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway

Open Medicine, 2023
The miR-141-3p has been reported to participate in regulating autophagy and tumor-stroma interactions in ovarian cancer (OC). We aim to investigate whether miR-141-3p accelerates the progression of OC and its effect on macrophage 2 polarization by ...
Zhao Jingyun, Liu Leilei, Zhao Wei, Lv Cuiting, Zhang Na, Jia Xinzhuan, Zhang Zhengmao   +6 more
doaj   +1 more source

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

Nature Communications, 2022
Targeting ferroptosis, a unique cell death modality triggered by unrestricted lipid peroxidation, in cancer therapy is hindered by our incomplete understanding of ferroptosis mechanisms under specific cancer genetic contexts.
Pranavi Koppula, Guang Lei, Yilei Zhang, Yuelong Yan, Chao Mao, Lavanya Kondiparthi, Jiejun Shi, Xiaoguang Liu, Amber Horbath, M. Das, Wei Li, M. Poyurovsky, Kellen L. Olszewski, B. Gan   +13 more
semanticscholar   +1 more source

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.

Genes & Development, 1999
Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated induction of phase II detoxifying and oxidative stress enzyme genes.
K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, Kazuhiko Igarashi, J. D. Engel, J. D. Engel, Masayuki Yamamoto   +7 more
semanticscholar   +1 more source

Monitoring Keap1-Nrf2 interactions in single live cells [PDF]

, 2014
The transcription factor NF-E2 p45-related factor 2 (Nrf2) and its negative regulator Kelch-like ECH associated protein 1 (Keap1) control the expression of nearly 500 genes with diverse cytoprotective functions.
Dinkova-Kostova, Albena, T, Baird, Liam, Llères, David, Swift, Sam, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T.   +5 more
core   +1 more source

Quantum Chemical Studies and Pharmacophore Modeling for Designing Novel Keap1 Antagonists that Enhance Nrf2 Mediated Neuroprotection

, 2021
In recent years, the significance of oxidative stress in the pathophysiology of Neurodegenerative/developmental disorders like Attention Deficit Hyperactivity Disorder, Parkinson\u27s and Alzheimer\u27s is being studied at an accelerating pace.
FNU, Srinidhi
core   +1 more source

Table_1_Clostridium butyricum Alleviates Enterotoxigenic Escherichia coli K88-Induced Oxidative Damage Through Regulating the p62-Keap1-Nrf2 Signaling Pathway and Remodeling the Cecal Microbial Community.docx

, 2021
Clostridium butyricum (CB) can enhance antioxidant capacity and alleviate oxidative damage, but the molecular mechanism by which this occurs remains unclear.
Haihua Li (211679), Jiayun Qiao (9774773), Kewei Wang (556371), Xuejiao Liu (838522), Zhiyuan Shang (9331907), Yingying Qiao (11678989)   +5 more
core   +1 more source

The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging

Oxidative Medicine and Cellular Longevity, 2021
Oxidative stress, a term that describes the imbalance between oxidants and antioxidants, leads to the disruption of redox signals and causes molecular damage.
Chao Yu, Jian-Hui Xiao
semanticscholar   +1 more source

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Nature, 2018
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood.
E. Mills, D. Ryan, H. Prag, D. Dikovskaya, D. Menon, Z. Zaslona, Mark P. Jedrychowski, Ana S. H. Costa, M. Higgins, E. Hams, John Szpyt, M. Runtsch, M. King, J. McGouran, R. Fischer, B. Kessler, A. F. Mcgettrick, M. Hughes, R. Carroll, Lee M. Booty, Elena V. Knatko, P. Meakin, M. Ashford, Louise K Modis, Gino Brunori, D. Sévin, P. Fallon, S. Caldwell, Edmund R. S. Kunji, Edward T. Chouchani, C. Frezza, A. Dinkova-Kostova, R. Hartley, M. Murphy, L. O’Neill   +34 more
semanticscholar   +1 more source

Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids [PDF]

, 2014
The transcription factor Nrf2 protects against a number of experimental pathologies, and is a promising therapeutic target. The clinical investigation of a potent Nrf2-inducing agent, the triterpenoid (TP) bardoxolone methyl (BARD), was recently halted ...
Lister, Adam, Shelton, Luke M., Kratschmar, Denise V., Copple, Ian M., Park, B. Kevin, Goldring, Christopher E., Honda, Tadashi, Odermatt, Alex, Walsh, Joanne, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T.   +10 more
core   +1 more source