Results 41 to 50 of about 53,484 (262)

Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer [PDF]

, 2016
Epidermal growth factor receptor (EGFR) inhibitors such as erlotinib are novel effective agents in the treatment of EGFR-driven lung cancer, but their clinical impact is often impaired by acquired drug resistance through the secondary T790M EGFR mutation.
Chater, E, De Bruin, E, Downward, J, Heynen, GJJE, Hu, Y, Li, H, Liu, Z, Pardo, OE, Roy, R, Seckl, MJS, Smit, EF, Stokes, W, Tang, H, Wang, Y   +13 more
core   +2 more sources

A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells [PDF]

, 2016
Nuclear erythroid related factor-2 (NRF2) is known to promote cancer therapeutic detoxification and crosstalk with growth promoting pathways. HER2 receptor tyrosine kinase is frequently overexpressed in cancers leading to uncontrolled receptor activation
Bown, James, Deeni, Yusuf Y., Goltsov, Alexey, Harrison, David J., Khalil, Hilal S., Langdon, Simon P., Soininen, Tero   +6 more
core   +3 more sources

Structural Characterization of KEAP1 R415K to Guide the Design of KEAP1‐Nrf2 Peptide Inhibitors

The FASEB Journal, 2021
Oxidative stress can cause extensive damage to DNA, proteins, and lipids. Thus, long‐term oxidative stress has been linked to many diseases including cancer and Alzheimer's disease. The highly‐charged binding interface between regulatory protein Kelch‐like ECH‐associated protein 1 (KEAP1) and transcription factor nuclear erythroid factor 2‐like 2 (Nrf2)
Gwendolyn Pyeatt, Samantha Muellers, Adrian Whitty, Karen Allen   +3 more
openaire   +1 more source

PGAM5 expression levels in heart failure and protection ROS-induced oxidative stress and ferroptosis by Keap1/Nrf2

Clinical and Experimental Hypertension, 2023
Objectives As a common and frequently occurring disease, heart failure has been paid more and more attention, but the mechanism of its occurrence and development is still unclear.
Shuangfei Li, Ping Wen, Dayong Zhang, Decai Li, Qidong Gao, Hong Liu, Yunfeng Di   +6 more
doaj   +1 more source

Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles

Antioxidants, 2022
KEAP1 is a cytoplasmic protein that functions as an adaptor for the Cullin-3-based ubiquitin E3 ligase system, which regulates the degradation of many proteins, including NFE2L2/NRF2 and p62/SQSTM1.
Elisabet Uribe-Carretero, Guadalupe Martinez-Chacón, Sokhna M. S. Yakhine-Diop, Gema Duque-González, Mario Rodríguez-Arribas, Eva Alegre-Cortés, Marta Paredes-Barquero, Saray Canales-Cortés, Elisa Pizarro-Estrella, Antonio Cuadrado, Rosa Ana González-Polo, José M. Fuentes, Mireia Niso-Santano   +12 more
doaj   +1 more source

Characterizing genomic alterations in cancer by complementary functional associations. [PDF]

, 2016
Systematic efforts to sequence the cancer genome have identified large numbers of mutations and copy number alterations in human cancers. However, elucidating the functional consequences of these variants, and their interactions to drive or maintain ...
A Azzalini, A Kraskov, A Kraskov, A Singh, A Young, AA Margolin, AJ Butte, Amir Reza Alizad-Rahvar, Andrew Aguirre, Arthur Liberzon, Aviad Tsherniak, B Luo, Barbara A Weir, C Ding, C Scholl, CA Miller, CD Correa, Chet Birger, Chiara Romualdi, CJ Vaske, Cory M Johannessen, D Feng, D Guardavaccaro, D Malhotra, D Nijhawan, D Pandey, DA Barbie, Daniel DiCara, David A Barbie, David J Konieczkowski, DD Shao, Diane D Shao, DP Hollern, DP Minde, DV Foster, EH Linfoot, Eliezer M Van Allen, F Vandin, F Vandin, Francisca Vazquez, G Ciriello, GA Darbellay, Gabriela Alexe, Gabriele Sales, Gad Getz, GM DeNicola, H Joe, H Peng, H Zou, Heidi Greulich, HW Cheung, J Barretina, J Lin, J Rosenbluh, JA McCubrey, Jesse S Boehm, Jill P Mesirov, JN Weinstein, Jong Wook Kim, Joseph Rosenbluh, JP Brunet, JS Boehm, L Chin, L Chin, L Waldron, Levi A Garraway, LM Solis, M Meyerson, Mahmoud Ghandi, Masoud Ardakani, MB Raeder, MD Leiserson, ME Abazeed, Michael Noble, Mohamed E Abazeed, MS Lawrence, MS Lawrence, Olga B Botvinnik, Omar Abudayyeh, P Tamayo, Pablo Tamayo, Peter S Hammerman, R Beroukhim, R Firestein, R Steuer, Rameen Beroukhim, S Pendyala, S Sheather, SS Brar, T Valenta, Travis I Zack, William C Hahn, Y Gu, Yashaswi Shrestha   +93 more
core   +1 more source

Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies [PDF]

, 2019
A significantly increased level of the reactive oxygen species (ROS) scavenger glutathione (GSH) has been identified as a hallmark of renal cell carcinoma (RCC). The proposed mechanism for increased GSH levels is to counteract damaging ROS to sustain the
Meierhofer, David, Xiao, Yi
core   +2 more sources

Emerging role of the pentose phosphate pathway in hepatocellular carcinoma [PDF]

, 2017
In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined.
Columbano, Amedeo, Kowalik, MARTA ANNA, Perra, Andrea   +2 more
core   +2 more sources

Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals [PDF]

Antioxidants, 2020
Epigenetics has provided a new dimension to our understanding of nuclear factor erythroid 2–related factor 2/Kelch-like ECH-associated protein 1 (human NRF2/KEAP1 and murine Nrf2/Keap1) signaling. Unlike the genetic changes affecting DNA sequence, the reversible nature of epigenetic alterations provides an attractive avenue for cancer interception ...
Shamee Bhattacharjee, Roderick H. Dashwood   +1 more
openaire   +3 more sources

Antioxidant and renal protective effects of Nano-selenium on adenine-induced acute renal failure in canines

Ecotoxicology and Environmental Safety
Acute renal failure is a common clinical disease in canines, affecting antioxidant levels and decreasing the body's resistance. This study aims to explore the therapeutic mechanism of Nano-selenium in acute renal failure.
Mengdi Zhang, Jindong Gao, Md. F. Kulyar, Wanhe Luo, Guodong Zhang, Xiaoqi Yang, Tianguang Zhang, Haihang Gao, Yuxuan Peng, Jiabin Zhang, Muhammad Altaf, Samah Attia Algharib, Donghai Zhou, Jianzhong He   +13 more
doaj   +1 more source