Results 41 to 50 of about 45,202 (305)
Modulation of NRF2/KEAP1 Signaling in Preeclampsia
Cells, 2023 Placentation is a key and tightly regulated process that ensures the normal development of the placenta and fetal growth. Preeclampsia (PE) is a hypertensive pregnancy-related disorder involving about 5–8% of all pregnancies and clinically characterized by de novo maternal hypertension and proteinuria. In addition, PE pregnancies are also characterized
Giovanni Tossetta +6 more
openaire +4 more sources
, 2015 The purpose of this study was to investigate the effects of acute exercise stress on the nuclear factor-erythroid2 p45-related factor 2 (Nrf2)/antioxidant response element (ARE) transactivation, Kelch-like ECH-associated protein 1(Keap1) cytosolic ...
Kong, Zhenxing +5 more
core +1 more source
Rev-competitive inhibition antagonizes Nrf2 binding to Keap1.
, 2022 (A-B) Biolayer interferometry graphs showing association and dissociation steps using different concentrations of Nrf2 (A) or Rev (B) to Keap1 immobilized on the anti-streptavidin biosensors.
Xue-Feng Wang (488982) +10 more
core +1 more source
Ecotoxicology and Environmental SafetyAcute renal failure is a common clinical disease in canines, affecting antioxidant levels and decreasing the body's resistance. This study aims to explore the therapeutic mechanism of Nano-selenium in acute renal failure.
Mengdi Zhang +13 more
doaj +1 more source
Molecules, 2020 The present study aimed to investigate the effects of astaxanthin (ASX) on ochratoxin A (OTA)-induced renal oxidative stress and its mechanism of action.
Lin Li +5 more
doaj +1 more source
CAV-1 prevents cholesterol impairment in the Nrf2-Keap1-GCLC pathway.
, 2016 (A) Protein expression of Nrf2 was determined in the total homogenate, cytoplasm, and nuclear fractions through western blotting by using GAPDH and anti-Lamin B1 as loading controls.
Ya-Hui Chen (514335) +5 more
core +1 more source
NQO1 Enzyme and its Role in Cellular Protection; an Insight
Iberoamerican Journal of Medicine, 2020 NAD(P)H:quinone oxidoreductase 1 (NQO1) is considered as one of the most significant enzyme in cellular defense due to its ability to detoxify reactive quinones and quinone imines to their less toxic hydroquinones forms. NQO1 is a xenobiotic metabolizing
Ahmed Atia, Azman Abdullah
doaj +1 more source
Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology
Biomolecules, 2020 Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various ...
Shuya Kasai +4 more
doaj +1 more source
Keap1 is degraded with IKKβ by autophagy.
, 2018 (A) Expression of Keap1 promoted IKKβ degradation and Keap1 is degraded concomitant with IKKβ. HEK293 cells were transfected with wild type HA-KKβ and Flag-Keap1. After 18 h of transfection, 10 μg/ml CHX was added to cell culture.
Yoshihiro Tsuchiya (748923) +6 more
core +1 more source
Reverse transcriptase-PCR for mutant and wild type KEAP1.
, 2013 (A) Primer positions for reverse transcriptase-PCR in KEAP1 exons. The asterisk indicates the position of c.879_880delinsA mutation in exon 3. The primer, KEAP1-mut-rvs, contains "T" nucleotide at the 3' end which is the complement of mutant "A ...
Risa Teshiba (416123) +5 more
core +1 more source