Results 41 to 50 of about 50,990 (303)

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents [PDF]

, 2014
The NRF2 signalling cascade provides a primary response against electrophilic chemicals and oxidative stress. The activation of NRF2-signaling is anticipated to have adverse clinical consequences; NRF2 is activated in a number of cancers, additionally ...
A Kenneth MacLeod, Lesley A McLaughlin, Henderson, Colin J., Kathryn H. Campbell (666563), McMahon, Michael, Michael McMahon, A. Kenneth MacLeod (666564), C Roland Wolf, Lesley A. McLaughlin (219228), MacLeod, A. Kenneth, C. Roland Wolf (293805), Kathryn H Campbell, Colin J Henderson, Michael McMahon (666562), Campbell, Kathryn H., McLaughlin, Lesley A., Colin J. Henderson (342321), Wolf, C. Roland   +17 more
core   +1 more source

Mutant p53–Nrf2 axis regulates the proteasome machinery in cancer

Molecular & Cellular Oncology, 2017
The proteasome machinery is a common target of gain-of-function p53 missense mutants. Upregulation of the proteasome fosters chemoresistance to proteasome inhibitors.
Kamil Lisek, Dawid Walerych, Giannino Del Sal   +2 more
doaj   +1 more source

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway

Journal of Translational Medicine, 2021
Background Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) induces uncontrolled and self-amplified pulmonary inflammation, and has high morbidity and mortality rates in critically ill patients.
Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, W. Sheng, Wanming Hao, Min Liu, Weihong Lv, W. Han   +9 more
semanticscholar   +1 more source

The NRF2/Keap1 pathway as a therapeutic target in inflammatory bowel disease.

Trends in Molecular Medicine, 2023
Oxidative stress (OS) is an important pathophysiological mechanism in inflammatory bowel disease (IBD). However, clinical trials investigating compounds directly targeting OS in IBD yielded mixed results.
S. Geertsema, A. Bourgonje, R. R. Fagundes, R. Gacesa, R. Weersma, H. van Goor, G. Mann, G. Dijkstra, K. Faber   +8 more
semanticscholar   +1 more source

PGAM5 expression levels in heart failure and protection ROS-induced oxidative stress and ferroptosis by Keap1/Nrf2

Clinical and Experimental Hypertension, 2023
Objectives As a common and frequently occurring disease, heart failure has been paid more and more attention, but the mechanism of its occurrence and development is still unclear.
Shuangfei Li, Ping Wen, Dayong Zhang, Decai Li, Qidong Gao, Hong Liu, Yunfeng Di   +6 more
doaj   +1 more source

Targeting Nrf2 signaling in dry eye [PDF]

International Journal of Ophthalmology
Dry eye, the most common ocular surface disease, can cause ocular surface tissue damage and discomfort symptoms and seriously affect people's quality of life. The etiology of dry eye is diverse, and its pathogenesis is complex.
Yu-Nuo Zhang, Wei-Jie Ouyang, Jiao-Yue Hu, Zu-Guo Liu   +3 more
doaj   +1 more source

CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Nature
For patients with advanced non-small-cell lung cancer (NSCLC), dual immune checkpoint blockade (ICB) with CTLA4 inhibitors and PD-1 or PD-L1 inhibitors (hereafter, PD-(L)1 inhibitors) is associated with higher rates of anti-tumour activity and immune ...
F. Skoulidis, Haniel A Araujo, Minh Truong Do, Yu Qian, Xin Sun, Ana Galán-Cobo, John Le, M. Montesion, Rachael Palmer, Nadine S. Jahchan, Joseph M. Juan, Chengyin Min, Yi Yu, Xuewen Pan, K. Arbour, N. Vokes, S. Schmidt, D. Molkentine, D. H. Owen, R. Memmott, P. Patil, M. Marmarelis, M. Awad, J. Murray, J. Hellyer, J. Gainor, A. Dimou, C. Bestvina, CA Shu, J. Riess, Collin M. Blakely, Chad V. Pecot, Laura Mezquita, Fabrizio Tabbó, M. Scheffler, S. Digumarthy, M. Mooradian, A. Sacher, Sally C. M. Lau, Andreas Saltos, J. Rotow, Rocio Perez Johnson, Corinne Liu, Tyler F Stewart, Sarah B. Goldberg, Jonathan Killam, Zenta Walther, K. Schalper, K. Davies, Mark G. Woodcock, V. Anagnostou, K. Marrone, P. Forde, B. Ricciuti, D. Venkatraman, E. V. Van Allen, A. Cummings, J. Goldman, H. Shaish, Melanie W Kier, Sharyn I. Katz, Charu Aggarwal, Ying Ni, J. Azok, Jeremy Segal, Lauren L. Ritterhouse, J. Neal, Ludovic Lacroix, Y. Elamin, M. Negrão, X. Le, V. Lam, Whitney E. Lewis, Haley N Kemp, Brett W. Carter, J. Roth, Stephen Swisher, Richard Lee, Teng Zhou, A. Poteete, Yifan Kong, Tomohiro Takehara, A. G. Paula, E. P. Parra Cuentas, C. Behrens, I. Wistuba, Jianjun Zhang, G. Blumenschein, C. Gay, L. Byers, D. Gibbons, Anne S. Tsao, J. J. Lee, T. Bivona, D. Camidge, J. Gray, N. Leighl, Benjamin Levy, J. Brahmer, M. Garassino, David R. Gandara, E. Garon, N. Rizvi, G. Scagliotti, Jürgen Wolf, D. Planchard, B. Besse, Roy S. Herbst, Heather A. Wakelee, N. Pennell, Alice T. Shaw, P. Jänne, David P. Carbone, M. Hellmann, C. Rudin, L. Albacker, H. Mann, Zhou Zhu, Zhongwu Lai, R. Stewart, Solange Peters, Melissa L. Johnson, Kwok-Kin Wong, A. Huang, M. Winslow, Michael J Rosen, Ian P. Winters, V. Papadimitrakopoulou, T. Cascone, P. Jewsbury, J. Heymach   +130 more
semanticscholar   +1 more source

Nrf2 regulates ROS production by mitochondria and NADPH oxidase.

, 2015
Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like ECH associated protein 1 (Keap1) thereby providing inducible antioxidant ...
Dinkova-Kostova, AT, Holmström, Kira M., Stjepana Kovaca, Kovac, S, Plamena R. Angelovaa, Ying Zhangb, Andrey Y. Abramova, Abramov, Andrey Y., Angelova, PR, Zhang, Y, Abramov, AY, Angelova, Plamena R., Kovac, Stjepana, Zhang, Ying, Kira M. Holmströma, Holmström, KM, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T., Albena T   +18 more
core   +1 more source

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Medicinal research reviews (Print), 2022
The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein ...
E. Crisman, Pablo Duarte, E. Daudén, A. Cuadrado, M. I. Rodríguez-Franco, Manuela G. López, R. León   +6 more
semanticscholar   +1 more source

CAV-1 prevents cholesterol impairment in the Nrf2-Keap1-GCLC pathway.

, 2016
(A) Protein expression of Nrf2 was determined in the total homogenate, cytoplasm, and nuclear fractions through western blotting by using GAPDH and anti-Lamin B1 as loading controls.
Ya-Hui Chen (514335), Yueh-Min Lin (297900), Wei-Wen Lin (514336), Chin-San Liu (171255), Li-Sung Hsu (514337), Shih-Li Su (514338)   +5 more
core   +1 more source