Results 61 to 70 of about 50,990 (303)

Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue

Frontiers in Aging Neuroscience, 2021
The Keap1-Nrf2 signaling axis is a validated and promising target for cellular defense and survival pathways. This minireview discusses the potential off-target effects and their impact on future drug development originating from Keap1-targeting small ...
Dmitry M. Hushpulian, Dmitry M. Hushpulian, Navneet Ammal Kaidery, Navneet Ammal Kaidery, Manuj Ahuja, Manuj Ahuja, Manuj Ahuja, Andrey A. Poloznikov, Sudarshana M. Sharma, Irina G. Gazaryan, Irina G. Gazaryan, Irina G. Gazaryan, Irina G. Gazaryan, Bobby Thomas, Bobby Thomas, Bobby Thomas, Bobby Thomas   +16 more
doaj   +1 more source

A small-molecule inhibitor of Keap1–Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites

EBioMedicine, 2023
Summary Background Macrophages at infection sites are considered as the promising therapeutic targets to prevent sepsis development. The Nrf2/Keap1 system acts as a critical modulator of the antibacterial activity of macrophages.
Yawei Wang, Binlin Tang, Huijuan Li, Jiancheng Zheng, Can Zhang, Ze-li Yang, Xu Tan, P. Luo, Le Ma, Yang Wang, Lei Long, Zelin Chen, Zhenliang Xiao, Lijie Ma, Jing-hua Zhou, Yu Wang, C. Shi   +16 more
semanticscholar   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Agmatine Mitigates Acetaminophen-induced Acute Liver Injury in Mice: Involvement of HMGB1/RAGE/NFκB and Nrf2/HO-1 Signaling Pathways [PDF]

Journal of Applied Veterinary Sciences
An overdose of acetaminophen (APAP) is considered one of the primary sources of drug-induced liver injury. This study aimed to explore the mechanism of agmatine (Agma) against APAP-induced acute liver injury (ALI) in mice.
Ahmed Abdelhady, Mohammed Ayman, Marwa Abdelmageed   +2 more
doaj   +1 more source

Cloning and expression analysis of Keap1 of golden pompano (Trachinotus ovatus) and response to oxidized fish oil and LPS administration

Aquaculture Reports, 2020
Keap1 is an important component of Nrf2-Keap1 signaling pathways. However, information about Keap1 in T. ovatus is quiet limit. Thus, the full length of Keap1 was cloned from T. ovatus in this study.
Jiajun Xie, Xu Chen, Xuanshu He, Jin Niu
doaj   +1 more source

Keap1 recognizes EIAV early accessory protein Rev to promote antiviral defense.

PLoS Pathogens, 2022
The Nrf2/Keap1 axis plays a complex role in viral susceptibility, virus-associated inflammation and immune regulation in host cells. However, whether or how the Nrf2/Keap1 axis is involved in the interactions between equine lentiviruses and their hosts ...
Yan Wang, Guanqin Ma, Xue-Feng Wang, Lei Na, Xing Guo, Jiaqi Zhang, Cong Liu, Cheng Du, Ting Qi, Yuezhi Lin, Xiaojun Wang   +10 more
doaj   +1 more source

The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2

iScience, 2022
Summary: Transcription factor Nrf2 and its negative regulator Keap1 orchestrate a cytoprotective response against oxidative, metabolic, and inflammatory stress. Keap1 is a drug target, with several small molecules in drug development.
Sharadha Dayalan Naidu, Takafumi Suzuki, Dina Dikovskaya, Elena V. Knatko, Maureen Higgins, Miu Sato, Miroslav Novak, José A. Villegas, Terry W. Moore, Masayuki Yamamoto, Albena T. Dinkova-Kostova   +10 more
doaj   +1 more source

Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress

Drug Delivery and Translational Research, 2023
Diabetic wounds are a serious complication of diabetes mellitus (DM) that can lead to persistent infection, amputation, and even death. Prolonged oxidative stress has been widely recognized as a major instigator in the development of diabetic wounds ...
Xuejiao Xiang, J. Chen, Tao Jiang, Chengqi Yan, Yu Kang, Maojie Zhang, Kaituo Xiang, Jiahe Guo, Guoyong Jiang, Cheng Wang, Xiangxu, Xiaofan Yang, Zhenbing Chen   +12 more
semanticscholar   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Cellular Modulators of the NRF2/KEAP1 Signaling Pathway in Prostate Cancer.

Frontiers in Bioscience, 2023
Prostate cancer is the second most common malignancy in men worldwide. Prostate cancer can be treated by surgery, radiotherapy and hormone therapy. The latter, in the form of androgen-deprivation therapy is needed to reduce prostate cancer progression at
G. Tossetta, S. Fantone, D. Marzioni, R. Mazzucchelli   +3 more
semanticscholar   +1 more source