Results 51 to 60 of about 50,990 (303)

Antioxidant and renal protective effects of Nano-selenium on adenine-induced acute renal failure in canines

Ecotoxicology and Environmental Safety
Acute renal failure is a common clinical disease in canines, affecting antioxidant levels and decreasing the body's resistance. This study aims to explore the therapeutic mechanism of Nano-selenium in acute renal failure.
Mengdi Zhang, Jindong Gao, Md. F. Kulyar, Wanhe Luo, Guodong Zhang, Xiaoqi Yang, Tianguang Zhang, Haihang Gao, Yuxuan Peng, Jiabin Zhang, Muhammad Altaf, Samah Attia Algharib, Donghai Zhou, Jianzhong He   +13 more
doaj   +1 more source

Protective Effect of Astaxanthin on Ochratoxin A-Induced Kidney Injury to Mice by Regulating Oxidative Stress-Related NRF2/KEAP1 Pathway

Molecules, 2020
The present study aimed to investigate the effects of astaxanthin (ASX) on ochratoxin A (OTA)-induced renal oxidative stress and its mechanism of action.
Lin Li, Yueli Chen, Danyang Jiao, Shuhua Yang, Lin Li, Peng Li   +5 more
doaj   +1 more source

Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives

Biomolecules, 2022
Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with increased prevalence and incidence. In addition to its macrovascular damage, through its microvascular complications, such as Diabetic Kidney Disease (DKD), DM ...
D. Tănase, Evelina Maria Gosav, M. Anton, M. Floria, Petronela Nicoleta Seritean Isac, L. Hurjui, C. Tărniceriu, C. Costea, M. Ciocoiu, C. Rezus   +9 more
semanticscholar   +1 more source

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.

, 2013
Cullin-RING ligases are multisubunit E3 ubiquitin ligases that recruit substrate-specific adaptors to catalyze protein ubiquitylation. Cul3-based Cullin-RING ligases are uniquely associated with BTB adaptors that incorporate homodimerization, Cul3 ...
Bullock, AN, Canning, P, Marsden, BD, Gileadi, Opher, Gileadi, O, Krojer, Tobias, Pike, AC, von Delft, F, Hojzan, V, Thangaratnarajah, C, Murray, James W., Cooper, CD, Keates, Tracy, Thangaratnarajah, Chancievan, Bullock, Alex N., Knapp, Stefan, Marsden, Brian D., Knapp, S, Hojzan, Viktorija, Murray, JW, von Delft, Frank, Chaikuad, A, Keates, T, Ayinampudi, Vikram, Ayinampudi, V, Pike, Ashley C.W., Chaikuad, Apirat, Krojer, T, Canning, Peter, Cooper, Christopher D.O., Bullock, Alexander   +30 more
core   +1 more source

Keap1/Nrf2 pathway in kidney cancer: Frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma [PDF]

, 2017
The Keap1/Nrf2 pathway is a master regulator of the cellular redox state through the induction of several antioxidant defence genes implicated in chemotherapeutic drugs resistance of tumor cells.
Parente P., Simone G., Copetti M, Fabrizio FP, Trombetta D, Kok K, Sentinelli S., Simone G, Picardo F, Balsamo T, Parente P, Kok K., Graziano P, Costantini M., Poeta L., Graziano P., Pantalone A, Gallucci M., Paranita F, Copetti M., Papalia R., Fazio V. M., Pantalone A., Fontana A., la Torre A., Muscarella L. A., Poeta L, Sentinelli S, De Salvo L, Paranita F., la Torre A, Fabrizio F. P., Pompeo V., Costantini M, Papalia R, Fontana A, Sparaneo A., Salvo L. D., Pompeo V, Fazio VM, Flammia G. P., Gallucci M, Trombetta D., Picardo F., Flammia GP, Sparaneo A, Balsamo T., Muscarella LA   +47 more
core   +3 more sources

NQO1 Enzyme and its Role in Cellular Protection; an Insight

Iberoamerican Journal of Medicine, 2020
NAD(P)H:quinone oxidoreductase 1 (NQO1) is considered as one of the most significant enzyme in cellular defense due to its ability to detoxify reactive quinones and quinone imines to their less toxic hydroquinones forms. NQO1 is a xenobiotic metabolizing
Ahmed Atia, Azman Abdullah
doaj   +1 more source

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

Biomolecules, 2020
Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various ...
Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura, Ken Itoh   +4 more
doaj   +1 more source

Hydrogen sulfide protects cardiomyocytes from doxorubicin-induced ferroptosis through the SLC7A11/GSH/GPx4 pathway by Keap1 S-sulfhydration and Nrf2 activation

Redox Biology
Recent studies have demonstrated that ferroptosis, a novel form of nonapoptotic regulated cell death plays an important role in doxorubicin (DOX)-induced cardiotoxicity (DoIC). Hydrogen sulfide (H2S) is emerging as the third important gaseous mediator in
H. Zhang, Jianan Pan, Shuying Huang, Xiaonan Chen, A. C. Y. Chang, Changqian Wang, Junfeng Zhang, Huili Zhang   +7 more
semanticscholar   +1 more source

FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice

Nature Communications, 2023
Hepatic ischemia-reperfusion injury (IRI) is a common complication occurs during hepatic resection and transplantation. However, the mechanisms underlying hepatic IRI have not been fully elucidated.
Gaozan Tong, Yiming Chen, Xixi Chen, Junfu Fan, K. Zhu, Zijing Hu, Santie Li, Junjie Zhu, Jianjun Feng, Zhaohang Wu, Zhenyu Hu, Bin Zhou, Litai Jin, Hui Chen, Jingling Shen, Weitao Cong, Xiaokun Li   +16 more
semanticscholar   +1 more source

Effects of different exercise durations on Keap1-Nrf2-ARE pathway activation in mouse skeletal muscle

, 2015
The purpose of this study was to investigate the effects of acute exercise stress on the nuclear factor-erythroid2 p45-related factor 2 (Nrf2)/antioxidant response element (ARE) transactivation, Kelch-like ECH-associated protein 1(Keap1) cytosolic ...
Kong, Zhenxing, Li, Tieying, Zhang, Ying, He, Sheyi, Wang, Jianxiong, Liu, Sixue   +5 more
core   +1 more source