Results 51 to 60 of about 45,202 (305)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Agmatine Mitigates Acetaminophen-induced Acute Liver Injury in Mice: Involvement of HMGB1/RAGE/NFκB and Nrf2/HO-1 Signaling Pathways [PDF]

Journal of Applied Veterinary Sciences
An overdose of acetaminophen (APAP) is considered one of the primary sources of drug-induced liver injury. This study aimed to explore the mechanism of agmatine (Agma) against APAP-induced acute liver injury (ALI) in mice.
Ahmed Abdelhady, Mohammed Ayman, Marwa Abdelmageed   +2 more
doaj   +1 more source

Cloning and expression analysis of Keap1 of golden pompano (Trachinotus ovatus) and response to oxidized fish oil and LPS administration

Aquaculture Reports, 2020
Keap1 is an important component of Nrf2-Keap1 signaling pathways. However, information about Keap1 in T. ovatus is quiet limit. Thus, the full length of Keap1 was cloned from T. ovatus in this study.
Jiajun Xie, Xu Chen, Xuanshu He, Jin Niu
doaj   +1 more source

Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue

Frontiers in Aging Neuroscience, 2021
The Keap1-Nrf2 signaling axis is a validated and promising target for cellular defense and survival pathways. This minireview discusses the potential off-target effects and their impact on future drug development originating from Keap1-targeting small ...
Dmitry M. Hushpulian, Dmitry M. Hushpulian, Navneet Ammal Kaidery, Navneet Ammal Kaidery, Manuj Ahuja, Manuj Ahuja, Manuj Ahuja, Andrey A. Poloznikov, Sudarshana M. Sharma, Irina G. Gazaryan, Irina G. Gazaryan, Irina G. Gazaryan, Irina G. Gazaryan, Bobby Thomas, Bobby Thomas, Bobby Thomas, Bobby Thomas   +16 more
doaj   +1 more source

CPDT and SF block only Keap1-mediated Nrf2 degradation and require key cysteine residues of Keap1.

, 2012
(A) Murine embryonic fibroblasts (MEF), including wild type MEF (Keap1+/+) and MEF with Keap1 knockout (Keap1−/−), were treated with vehicle, MG132 (25 µM), CPDT (50 µM) or SF (8 µM) for 6 h. Cells were then harvested for IB of Nrf2 and GAPDH.
Yuesheng Zhang (168364), Joseph D. Paonessa (168359), Yun Li (692280)   +2 more
core   +1 more source

KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance

, 2023
Summary: Lung cancer treatment has benefited greatly through advancements in immunotherapies. However, immunotherapy often fails in patients with specific mutations like KEAP1, which are frequently found in lung adenocarcinoma.
Corrin A. Wohlhieter, Terkild B. Buus, Makiko Hayashi, Wu, Warren L., Kwok-Kin Wong, Herrera, Alberto, Metamia Ciampricotti, Khanna, Kamal M., Karatza, Angeliki, Ivanova, Ellie, Hayashi, Makiko, Yuan Hao, Rajalingam, Sahith, Sabrina Solis, Eric Bartnicki, Anastasia-Maria Zavitsanou, Pillai, Ray, Ray Pillai, Ellie Ivanova, Solis, Sabrina, Hao, Yuan, Warren L. Wu, John T. Poirier, Papagiannakopoulos, Thales, Wohlhieter, Corrin A., Sahith Rajalingam, Rashidfarrokhi, Ali, Poirier, John T., Wong, Kwok Kin, Harvey I. Pass, Bartnicki, Eric, Ali Rashidfarrokhi, Kamal M. Khanna, Pass, Harvey I., Alberto Herrera, Zavitsanou, Anastasia Maria, Moreira, Andre L., Koralov, Sergei B., Triantafyllia Karakousi, Andre L. Moreira, Ciampricotti, Metamia, Sergei B. Koralov, Yeaton, Anna H., Angeliki Karatza, Burcu Karadal-Ferrena, Thales Papagiannakopoulos, Karakousi, Triantafyllia, Rudin, Charles M., Tsirigos, Aristotelis, Anna H. Yeaton, Buus, Terkild B., Charles M. Rudin, Karadal-Ferrena, Burcu, Aristotelis Tsirigos   +53 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Keap1 recognizes EIAV early accessory protein Rev to promote antiviral defense.

PLoS Pathogens, 2022
The Nrf2/Keap1 axis plays a complex role in viral susceptibility, virus-associated inflammation and immune regulation in host cells. However, whether or how the Nrf2/Keap1 axis is involved in the interactions between equine lentiviruses and their hosts ...
Yan Wang, Guanqin Ma, Xue-Feng Wang, Lei Na, Xing Guo, Jiaqi Zhang, Cong Liu, Cheng Du, Ting Qi, Yuezhi Lin, Xiaojun Wang   +10 more
doaj   +1 more source

The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2

iScience, 2022
Summary: Transcription factor Nrf2 and its negative regulator Keap1 orchestrate a cytoprotective response against oxidative, metabolic, and inflammatory stress. Keap1 is a drug target, with several small molecules in drug development.
Sharadha Dayalan Naidu, Takafumi Suzuki, Dina Dikovskaya, Elena V. Knatko, Maureen Higgins, Miu Sato, Miroslav Novak, José A. Villegas, Terry W. Moore, Masayuki Yamamoto, Albena T. Dinkova-Kostova   +10 more
doaj   +1 more source

The KEAP1/NRF2 Signaling Pathway in Keratinization

Antioxidants, 2020
Keratinization is a tissue adaptation, but aberrant keratinization is associated with skin disorders such as ichthyoses, atopic dermatitis, psoriasis, and acne. The disease phenotype stems from the interaction between genes and the environment; therefore, an understanding of the adaptation machinery may lead to a new appreciation of pathomechanisms ...
Yosuke Ishitsuka, Tatsuya Ogawa, Dennis Roop   +2 more
openaire   +3 more sources