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S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy
Molecular Cell, 2023 p62 is a well-characterized autophagy receptor that recognizes and sequesters specific cargoes into autophagosomes for degradation. p62 promotes the assembly and removal of ubiquitinated proteins by forming p62-liquid droplets. However, it remains unclear how autophagosomes efficiently sequester p62 droplets.
Aimin Yang
exaly +5 more sources
Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination [PDF]
Cell Reports, 2017 p62/SQSTM1 (p62) is a scaffolding protein that facilitates the formation and degradation of ubiquitinated aggregates via its self-interaction and ubiquitin binding domains.
Conrad C. Weihl +2 more
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p62-Nrf2-p62 Mitophagy Regulatory Loop as a Target for Preventive Therapy of Neurodegenerative Diseases [PDF]
Brain Sciences, 2020 Turnover of the mitochondrial pool due to coordinated processes of mitochondrial biogenesis and mitophagy is an important process in maintaining mitochondrial stability. An important role in this process is played by the Nrf2/ARE signaling pathway, which
Artem P. Gureev +4 more
doaj +3 more sources
p62: a versatile multitasker takes on cancer [PDF]
Trends in Biochemical Sciences, 2012 Since its initial discovery as an atypical protein kinase C (PKC)-interacting protein, p62 has emerged as a crucial molecule in a myriad of cellular functions. This multifunctional role of p62 is explained by its ability to interact with several key components of various signaling mechanisms.
Jorge Moscat, Maria Diaz-Meco
exaly +3 more sources
Alternol-Induced Oxidative Modification of SQSTM1/p62 Is Associated with Nrf2 Signaling and Autophagy-Related Responses in Prostate Cancer Cells [PDF]
AntioxidantsSQSTM1/p62 is a multifunctional scaffold protein that plays important roles in selective autophagy and cellular redox homeostasis. While phosphorylation-dependent regulation of p62 has been extensively studied, the functional significance of oxidative ...
Wang Liu +9 more
doaj +2 more sources
Frontiers in Physiology, 2022 Introduction: Obesity is a risk factor for many diseases because it leads to a reduction in skeletal muscle mass and promotes insulin resistance. p62/Sqstm1-knockout mice are a model of metabolic syndrome; show obesity, insulin resistance, and non ...
Ikuru Miura +8 more
doaj +1 more source
‘High vault-age’: non-coding RNA control of autophagy [PDF]
Open Biology, 2020 RNA-binding proteins typically change the fate of RNA, such as stability, translation or processing. Conversely, we recently uncovered that the small non-coding vault RNA 1-1 (vtRNA1-1) directly binds to the autophagic receptor p62/SQSTM1 and changes the
Magdalena Büscher +2 more
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Frontiers in Bioscience-Landmark, 2022 Background: p62 is a multi-domain protein and participates in a variety of cellular biological activities. p62 is also related to tumor malignancy. However, the underlying molecular mechanism of p62 regulating the progression of hepatocellular carcinoma (
Weibang Yang +8 more
doaj +1 more source
Pathogens, 2022 The intracellular pathogen, Mycobacterium tuberculosis (M. tb) uses various mechanisms to evade its killing. One of such is phagosomal damage and cytosolic translocation which is then targeted by the host’s bactericidal autophagy pathway. It is suggested
Naomi Okugbeni +5 more
doaj +1 more source
Physiological Reports, 2021 Exercise ameliorates nonalcoholic fatty liver disease (NAFLD) by inducing phenotypic changes in Kupffer cells (KCs). p62/Sqstm1‐knockout (p62‐KO) mice develop NAFLD alongside hyperphagia‐induced obesity. We evaluated (1) the effects of long‐term exercise
Ikuru Miura +9 more
doaj +1 more source