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P62: An emerging oncotarget for osteolytic metastasis
Journal of Bone Oncology, 2016 Bone metastasis occurs in the majority of late-stage tumors with poor prognosis. It is mainly classified as osteoblastic metastasis and osteolytic metastasis. The pathogenesis of osteolytic metastasis is a "vicious cycle" between tumor cells and bone cells (primarily the osteoclasts), which is mediated by secretory factors. The P62 adapter protein is a
Jing Zhang, Zuozhang Yang, Jian Dong
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TRIB3-P62 interaction, diabetes and autophagy
Oncotarget, 2015 Type 2 diabetes (T2D) and cancer are two common diseases with tremendous impact on health worldwide. Epidemiologic evidence suggests that cancer incidence is associated with diabetes as well as certain diabetic risk factors and diabetic medications.
Fang, Hua, Zhuo-Wei, Hu
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Cells, 2019 Recent studies have proven that Dimethylfumarate (DMF) has a marked anti-proliferative impact on diverse cancer entities e.g., on malignant melanoma. To explore its anti-tumorigenic potential, we examined the effects of DMF on human colon carcinoma cell ...
Irina Kaluzki +7 more
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p62/SQSTM1/A170: Physiology and pathology
Pharmacological Research, 2012 p62/SQSTM1/A170 (hereafter referred to as p62) is a stress-inducible intracellular protein known to regulate various signal transduction pathways involved in cell survival and cell death. Comprehensive analysis of LC3 (an autophagosome localizing protein)-binding proteins resulted in the recognition of autophagy and p62.
Masaaki, Komatsu +2 more
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Potential role of p62 in tumor development [PDF]
Autophagy, 2011 p62 is a ubiquitously expressed cellular protein conserved in metazoa but not in plants and fungi, and is known as one of the selective substrates for autophagy. This protein is localized at the autophagosome formation site and directly interacts with LC3, an autophagosome-localizing protein, and it is incorporated subsequently into the autophagosome ...
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Clinical and Translational MedicineBackground Spinal cord injury (SCI)‐induced neuroinflammation and oxidative stress (OS) are crucial events causing neurological dysfunction. Aconitate decarboxylase 1 (ACOD1) and its metabolite itaconate (Ita) inhibit inflammation and OS by promoting ...
Zhanyang Qian +7 more
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mTOR promotes the formation and growth of tertiary lymphoid tissues in the kidney
Frontiers in ImmunologyTertiary lymphoid tissues (TLTs) are ectopic lymphoid tissues that form de novo in nonlymphoid organs. In this study, we demonstrate that the kidneys of aged mice with a renal tubule-specific knockout of autophagy-related 7 (Atg7) contain numerous and ...
Daniel J. Atwood +8 more
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Frontiers in Bioscience-LandmarkBackground: Autophagy is a conserved catabolic process that promotes cellular homeostasis and health. Although exercise is a well-established inducer of this pathway, little is known about the effects of different types of training ...
Isaac Tamargo-Gómez +6 more
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Virology JournalUsutu virus (USUV) is an emerging orthoflavivirus, which mainly affects birds but in rare cases can cause severe neuroinvasive disease in humans. The virus relies on a multitude of host cell proteins, molecules and cellular processes for its replication,
Tessa Nelemans +6 more
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The Role of the Ubiquitin-Proteasome System and p62 in the Development of Neurodegenerative Disease [PDF]
Impulse: The Premier Undergraduate Neuroscience Journal, 2006 The ubiquitin-proteasome system (UPS) is the pathway for degradation of nuclear and cytosolic proteins that are aged, damaged, or misfolded. Malfunctions in the UPS have been implicated in a wide variety of neurodegenerative diseases. Some proteins, when
Michael G. Paine, Marie W. Wooten
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