Results 31 to 40 of about 96,733 (290)

Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis

Military Medical Research, 2022
Background Cerebral ischemia-reperfusion injury (CIRI) refers to a secondary brain injury that can occur when the blood supply to the ischemic brain tissue is restored. However, the mechanism underlying such injury remains elusive.
Xue Zeng, Yun-Dong Zhang, Rui-Yan Ma, Yuan-Jing Chen, Xin-Ming Xiang, Dong-Yao Hou, Xue-Han Li, He Huang, Tao Li, Chen-Yang Duan   +9 more
doaj   +1 more source

Autophagy and p62 in Cardiac Proteinopathy [PDF]

Circulation Research, 2011
Rationale: Recent studies suggest an important role of autophagy in protection against αB-crystallin-based (CryAB R120G ) desmin-related cardiomyopathies (DRC), but this has not been demonstrated in a different model of cardiac proteinopathy.
Qingwen, Zheng, Huabo, Su, Mark J, Ranek, Xuejun, Wang   +3 more
openaire   +2 more sources

Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy [PDF]

, 2015
Spinal and bulbar muscular atrophy (SBMA) is characterized by loss of motoneurons and sensory neurons, accompanied by atrophy of muscle cells. SBMA is due to an androgen receptor containing a polyglutamine tract (ARpolyQ) that misfolds and aggregates ...
Aggarwal, Tanya, Cicardi, Maria Elena, Crippa, Valeria, Cristofani, Riccardo, Galbiati, Mariarita, Giorgetti, Elisa, Lieberman, Andrew P., Meroni, Marco, Messi, Elio, Milioto, Carmelo, Pennuto, Maria, Piccolella, Margherita, Polanco, Maria Josefa, Poletti, Angelo, Rocchi, Anna, Rusmini, Paola   +15 more
core   +2 more sources

Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats [PDF]

, 2018
Mutations in ubiquilin2 (UBQLN2) have been linked to abnormal protein aggregation in amyotrophic lateral sclerosis (ALS). The mechanisms underlying UBQLN2-related neurodegenerative diseases remain unclear.
Chen, Tianhong, Gao, Limo, Huang, Bo, Huang, Cao, Shi, Xinglong   +4 more
core   +2 more sources

LPS-induced Pellino3 degradation is mediated by p62-dependent autophagy [PDF]

, 2012
Background: In macrophages Toll-like receptor 4 (TLR4) is activated in response to lipopolysaccharide (LPS) and induces proinflammatory cytokine expression. Therefore, mechanisms terminating proinflammatory gene expression are important.
Brüne, Bernhard, Eifler, Lisa, Heeg, Annika, Heide, Hermann, Knape, Tilo, Knethen, Andreas von, Kuchler, Laura   +6 more
core   +1 more source

The Binding of PD-L1 and Akt Facilitates Glioma Cell Invasion Upon Starvation via Akt/Autophagy/F-Actin Signaling

Frontiers in Oncology, 2019
Glioma, especially glioblastoma, is pathologically characterized by high aggressiveness, which largely contributed to the ineffectiveness of current therapies.
Ruo Qiao Chen, Xiao Hong Xu, Feng Liu, Chun Yang Li, Yuan Jun Li, Xiang Rui Li, Guo Yong Jiang, Feng Hu, Di Liu, Feng Pan, Xin Yao Qiu, Xiao Qian Chen   +11 more
doaj   +1 more source

Expression Pattern of p62 in Primary Age-Related Tauopathy: Staging of p62 in PART

Frontiers in Aging Neuroscience, 2022
The present study analyzed the distribution pattern of p62 immunoreactivity in brains of primary age-related tauopathy (PART) and Braak NFT matched pre-AD and Alzheimer’s disease (AD) patients using immunohistochemistry in combination with semi-quantitative evaluation.
Xin Wang, Xin Wang, Lei Zhang, Lei Zhang, Hui Lu, Juanli Wu, Huazheng Liang, Bing Sun, Keqing Zhu, Keqing Zhu   +9 more
openaire   +3 more sources

Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy [PDF]

, 2017
Mitophagy orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological accumulation and contributing to cellular homeostasis.
A Jain, A Morelli, A Moustapha, AE Dikalova, AK Prasad, AP Joselin, B Bekdeser, B Bingol, B Mishra, C Hu, C Jo, D Faccenda, D Marcotte, D Narendra, DA East, DP Narendra, F Strappazzon, G Ashrafi, H Katayama, HC Bertrand, I Kim, J Gatliff, J Gatliff, J Lee, J Li, J Yan, J-A Pan, J-Y Lee, JD Clarke, JD Hayes, K Palikaras, KL Cheung, L Baird, L Mastrangelo, LC Gomes, M Frank, M Lazarou, MV Tsiper, N Wakabayashi, ND Georgakopoulos, Q Jiang, RC Scaduto, RLA Vries de, S Holm, S Kovac, S Li, S Melser, SE Dickinson, T Saito, X Xie, Y Ichimura, Y Katsuragi, Y Wang, Z-Y Jiang   +53 more
core   +3 more sources

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner [PDF]

, 2016
Bladder cancer (BC) is a common urologic tumor characterized by high risk of recurrence and mortality. Capsaicin (CPS), used as an intravesical drug for overactive bladder, was demonstrated to induce cell death in different cancer cells including BC ...
Amantini, C, CARDINALI, CLAUDIO, GISMONDI, Angela, MORELLI, MARIA BEATRICE, Nabissi, M, Santoni, G., Santoni, M   +6 more
core   +1 more source

RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems

Redox Biology, 2017
Reactivation of p53 and induction of tumor cell apoptosis (RITA) is a small molecule that blocks p53–MDM2 interaction, thereby reactivating p53 in tumors.
Daiha Shin, Eun Hye Kim, Jaewang Lee, Jong-Lyel Roh   +3 more
doaj   +1 more source