Results 31 to 40 of about 68,926 (299)

A Second Pathogenic Protein, PolyGN2C-iso2, Reveals a Dual-Protein Pathology in Neuronal Intranuclear Inclusion Disease. [PDF]

Adv Sci (Weinh)
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Zhang K, Ma W, Zhou Y, Wu Z, Gao P, Niu H, Tai H, Zhao T, Dong Z, Li L, Zhang Y, Wang A, Shen S, Li Y, Yu S, Peng Y, Sheng W, Dong X, Pan H, Shi K, Koziol MJ, Wu X, Zhang Z.   +22 more
europepmc   +2 more sources

The Binding of PD-L1 and Akt Facilitates Glioma Cell Invasion Upon Starvation via Akt/Autophagy/F-Actin Signaling

Frontiers in Oncology, 2019
Glioma, especially glioblastoma, is pathologically characterized by high aggressiveness, which largely contributed to the ineffectiveness of current therapies.
Ruo Qiao Chen, Xiao Hong Xu, Feng Liu, Chun Yang Li, Yuan Jun Li, Xiang Rui Li, Guo Yong Jiang, Feng Hu, Di Liu, Feng Pan, Xin Yao Qiu, Xiao Qian Chen   +11 more
doaj   +1 more source

Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas. [PDF]

, 2016
Esophageal adenocarcinomas (EAC) are aggressive tumors with considerable rates of chemoresistance. Autophagy is a lysosome-dependent degradation process, characterized by the formation of vesicles called autophagosomes, and has been implicated in cancer.
Seiler, Christian A., Tschan, Mario, Kröll, Dino, Schläfli, Anna, Dislich, Bastian, Berezowska, Sabina Anna, Langer, Rupert, Adams, Olivia Joan   +7 more
core   +2 more sources

RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems

Redox Biology, 2017
Reactivation of p53 and induction of tumor cell apoptosis (RITA) is a small molecule that blocks p53–MDM2 interaction, thereby reactivating p53 in tumors.
Daiha Shin, Eun Hye Kim, Jaewang Lee, Jong-Lyel Roh   +3 more
doaj   +1 more source

Comparative Gene Expression Analysis in WM164 Melanoma Cells Revealed That β-β-Dimethylacrylshikonin Leads to ROS Generation, Loss of Mitochondrial Membrane Potential, and Autophagy Induction

Molecules, 2018
Skin cancer is currently diagnosed as one in every three cancers. Melanoma, the most aggressive form of skin cancer, is responsible for 79% of skin cancer deaths and the incidence is rising faster than in any other solid tumor type.
Nadine Kretschmer, Alexander Deutsch, Christin Durchschein, Beate Rinner, Alexander Stallinger, Juan Carlos Higareda-Almaraz, Marcel Scheideler, Birgit Lohberger, Rudolf Bauer   +8 more
doaj   +1 more source

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

Neurobiology of Disease, 2015
Huntington Disease (HD) is a progressive neurodegenerative disease caused by an elongated CAG repeat in the huntingtin (HTT) gene that encodes a polyglutamine tract in the HTT protein.
Bibiana K.Y. Wong, Dagmar E. Ehrnhoefer, Rona K. Graham, Dale D.O. Martin, Safia Ladha, Valeria Uribe, Lisa M. Stanek, Sonia Franciosi, Xiaofan Qiu, Yu Deng, Vlad Kovalik, Weining Zhang, Mahmoud A. Pouladi, Lamya S. Shihabuddin, Michael R. Hayden   +14 more
doaj   +1 more source

Autophagy Promotes Duck Tembusu Virus Replication by Suppressing p62/SQSTM1-Mediated Innate Immune Responses In Vitro

Vaccines, 2020
Duck Tembusu virus (DTMUV) has recently appeared in ducks in China and the key cellular determiners for DTMUV replication in host cells remain unknown.
Zhiqiang Hu, Yuhong Pan, Anchun Cheng, Xingcui Zhang, Mingshu Wang, Shun Chen, Dekang Zhu, Mafeng Liu, Qiao Yang, Ying Wu, Xinxin Zhao, Juan Huang, Shaqiu Zhang, Sai Mao, Xumin Ou, Yanling Yu, Ling Zhang, Yunya Liu, Bin Tian, Leichang Pan, Mujeeb Ur Rehman, Zhongqiong Yin, Renyong Jia   +22 more
doaj   +1 more source

Nonstructural proteins 2B and 4A of Tembusu virus induce complete autophagy to promote viral multiplication in vitro

Veterinary Research, 2023
Tembusu virus (TMUV) is an emerging flavivirus that has broken out in different regions of China. TMUV infection has been reported to induce autophagy in duck embryo fibroblast cells.
Wangyang Tan, Senzhao Zhang, Yu He, Zhen Wu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Di Sun, Bin Tian, Shun Chen, Anchun Cheng   +19 more
doaj   +1 more source

Identification of the relationship between biomarkers of autophagy, apoptosis and inflammation in the acute period of atherothrombotic ischemic stroke

Медицинская иммунология, 2023
The postischemic inflammatory response plays a significant role in the pathogenesis of acute ischemic stroke (IS). It has been established that acute IS is accompanied by aseptic inflammation, which induces the activation of costimulatory molecules in ...
A. V. Lugovaya, N. M. Kalinina, A. M. Ivanov, Yu. V. Nikitin, I. А. Sukhina, V. F. Mitreikin, E. V. Semenova   +6 more
doaj   +1 more source

Mutant KRAS-m⁶A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target. [PDF]

Adv Sci (Weinh)
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Chen D, Huang P, Tao R, Ji F, Wei Q, Ko LH, Zhou L, Chen H, Cheung A, Kang W, To KF, Yu J, Wong CC.   +12 more
europepmc   +2 more sources