Identification and functional analysis of Joka2, a tobacco member of the family of selective autophagy cargo receptors [PDF]
, 2011 Two main mechanisms of protein turnover exist in eukaryotic cells: the ubiquitin-proteasome system and the autophagylysosomal pathway. Autophagy is an emerging important constituent of many physiological and pathological processes, such as response to ...
Sirko, Agnieszka +17 more
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Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake [PDF]
, 2020 p62/SQSTM1 is an autophagy receptor and signaling adaptor with an N-terminal PB1 domain that forms the scaffold of phase-separated p62 bodies in the cell.
Hagen, Wim J. H. +14 more
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p62 acts as an oncogene and is targeted by miR-124-3p in glioma
Cancer Cell International, 2019 Background Glioma is the most common central nervous system (CNS) tumour. p62, an important autophagy adaptor, plays a crucial role in cancer. However, the role of p62 in the progression of glioma is poorly characterized.
Danni Deng +9 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background and Aims: TRIM21 is a ubiquitin E3 ligase that is implicated in numerous biological processes including immune response, cell metabolism, redox homeostasis, and cancer development.
Fang Wang +22 more
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Autophagy and p62 in Cardiac Proteinopathy [PDF]
Circulation Research, 2011 Rationale: Recent studies suggest an important role of autophagy in protection against αB-crystallin-based (CryAB R120G ) desmin-related cardiomyopathies (DRC), but this has not been demonstrated in a different model of cardiac proteinopathy.
Qingwen, Zheng +3 more
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Regulation of autophagy by AMP-activated protein kinase/ sirtuin 1 pathway reduces spinal cord neurons damage [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after
Peng Yan +5 more
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Expression Pattern of p62 in Primary Age-Related Tauopathy: Staging of p62 in PART
Frontiers in Aging Neuroscience, 2022 The present study analyzed the distribution pattern of p62 immunoreactivity in brains of primary age-related tauopathy (PART) and Braak NFT matched pre-AD and Alzheimer’s disease (AD) patients using immunohistochemistry in combination with semi-quantitative evaluation.
Xin Wang +9 more
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Structural and functional characterization of the p62 complex, a subcomplex of the nuclear pore complex [PDF]
, 2008 The nuclear pore complex (NPC) is a highly conserved eukaryotic protein complex, which perforates the nuclear envelope and regulates nucleocytoplasmic transport of cargos between the cytoplasm and nucleus.
Schwarz-Herion, Kyrill
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Expression Analysis of Autophagy Related Markers LC3B, p62 and HMGB1 Indicate an Autophagy-Independent Negative Prognostic Impact of High p62 Expression in Pulmonary Squamous Cell Carcinomas [PDF]
, 2018 Autophagy is involved in maintaining cellular homeostasis under stress conditions. It also plays an important role in various diseases including cancer.
Schmid, Ralph +11 more
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Molecular & Cellular Oncology, 2021 Membraneless condensates have recently caught the attention of biologists as hubs for cellular components required for catalysis of basic processes.
Afu Fu +3 more
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