Results 51 to 60 of about 63,564 (302)

Identification of the relationship between biomarkers of autophagy, apoptosis and inflammation in the acute period of atherothrombotic ischemic stroke

Медицинская иммунология, 2023
The postischemic inflammatory response plays a significant role in the pathogenesis of acute ischemic stroke (IS). It has been established that acute IS is accompanied by aseptic inflammation, which induces the activation of costimulatory molecules in ...
A. V. Lugovaya, N. M. Kalinina, A. M. Ivanov, Yu. V. Nikitin, I. А. Sukhina, V. F. Mitreikin, E. V. Semenova   +6 more
doaj   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Data_Sheet_1_DC32, a Dihydroartemisinin Derivative, Ameliorates Collagen-Induced Arthritis Through an Nrf2-p62-Keap1 Feedback Loop.docx

, 2018
Artemisinins have been reported to have diverse functions, such as antimalaria, anticancer, anti-inflammation, and immunoregulation activities. DC32 [(9α,12α-dihydroartemisinyl) bis(2′-chlorocinnmate)], a dihydroartemisinin derivative possessing potent ...
Chunhua Yao (2471311), Menglin Fan (6010460), Yanan Li (94033), Jihua Liu (1395481), Boyang Yu (806005), Xiufeng Liu (739915)   +5 more
core   +1 more source

p62 links autophagy and Nrf2 signaling [PDF]

Free Radical Biology and Medicine, 2015
The Nrf2-Keap1-ARE pathway is a redox and xenobiotic sensitive signaling axis that functions to protect cells against oxidative stress, environmental toxicants, and harmful chemicals through the induction of cytoprotective genes. To enforce strict regulation, cells invest a great deal of energy into the maintenance of the Nrf2 pathway to ensure rapid ...
Tao, Jiang, Bryan, Harder, Montserrat, Rojo de la Vega, Pak K, Wong, Eli, Chapman, Donna D, Zhang   +5 more
openaire   +2 more sources

SQSTM1/p62 as a therapeutic target in cancer

Autophagy Reports, 2022
Cell survival depends on dynamic interactions among the signaling pathways that control the endoplasmic reticulum (ER) stress response, macroautophagy/autophagy and apoptotic cell death. Our recent study reported an association of cytoplasmic SQSTM1/p62-mediated autophagy with disease progression and therapy resistance in head and neck squamous cell ...
Hyeong-Reh C. Kim, Abdo J. Najy, Seongho Kim, Yong Tae Kwon   +3 more
openaire   +3 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

p62-mediated selective autophagy is endogenously induced in viral latency and correlates with ROS-Keap1-NRF2 pathway activity.

, 2019
A. Endogenous ROS production in viral latency was measured by flow cytometry with the CellRox Green reagent (Invitrogen). Three independent repeats were conducted, and representative results are shown.
Ayrianna Sparks-Wallace (6631682), Carissa Kohne (6631691), Shunbin Ning (628000), Kenton H. Hall (6631694), Jonathan P. Moorman (219560), Mary E. A. Howell (6631679), Caroline Hawkins (6631685), Zhi Q. Yao (219563), Ling Wang (56577), Camri A. Nicksic (6631688)   +9 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Targeting YAP‐p62 signaling axis suppresses the EGFR‐TKI‐resistant lung adenocarcinoma

Cancer Medicine, 2021
Background Despite the progress of advanced target therapeutic agents and immune checkpoint inhibitors, EGFR‐TKI resistance is still one of the biggest obstacles in treating lung cancer. Clinical studies with autophagy inhibitors are actively underway to
Hee Sun Park, Da‐Hye Lee, Da Hyun Kang, Min‐Kyung Yeo, Goeun Bae, Dahye Lee, Geon Yoo, Ju‐Ock Kim, Eunyoung Moon, Yang Hoon Huh, Sang‐Hee Lee, Eun‐Kyeong Jo, Sang Yeon Cho, Jeong Eun Lee, Chaeuk Chung   +14 more
doaj   +1 more source

Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson’s disease [PDF]

, 2016
Mutations or inactivation of parkin, an E3 ubiquitin ligase, are associated with familial form or sporadic Parkinson’s disease (PD), respectively, which manifested with the selective vulnerability of neuronal cells in substantia nigra (SN) and striatum ...
Shanshan Li, Wang, Hongxia, Zhang, Zhuohua, Dongmei Wang, Nan Sui, Han, Zehan, Haiteng Deng, Hao Wu, Biao Ma, Tieshan Tang, Ma, Biao, Ziheng Chen, Pingping Song, Wang, Dongmei, Quan Chen, Chen, Quan, Zhu, Yushan, Gao, Ruize, Tan, Zheng, Lu, Tieyuan, Sui, Nan, Wu, Hao, Yushan Zhu, Chen, Ziheng, Zehan Han, Deng, Haiteng, Song, Pingping, Tieyuan Lu, Zhuohua Zhang, Ruize Gao, Hongxia Wang, Guanhua Rao, Tang, Tieshan, Li, Shanshan, Rao, Guanhua, Zheng Tan   +35 more
core   +1 more source