Results 71 to 80 of about 63,564 (302)

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer [PDF]

Cell, 2009
The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-kappaB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that
Moscat, Jorge, Diaz-Meco, Maria T.
openaire   +2 more sources

Acute resistance exercise induces sestrin2 phosphorylation and p62 dephosphorylation in human skeletal muscle [PDF]

, 2017
Sestrins (1, 2, 3) are a family of stress-inducible proteins capable of attenuating oxidative stress, regulating metabolism, and stimulating autophagy. Sequestosome1 (p62) is also a stress-inducible multifunctional protein acting as a signaling hub for ...
Nina Zeng, Roberts, Llion, Cameron J. Mitchell, D’Souza, Randall F., Markworth, James F., Cameron-Smith, David, D\u27Souza, Randall F., Llion A. Roberts, Mitchell, Cameron J., James F. Markworth, Roberts, Llion A., Randall F. D'Souza, D'Souza, Randall, Mitchell, Cameron, Roberts, Llion A, Peake, Jonathan M., Cameron‐smith, David, David Cameron-Smith, Peake, Jonathan M, Mitchell, Cameron J, Vandre C. Figueiredo, Jonathan M. Peake, D'Souza, Randall F, Figueiredo, Vandre C., Zeng, Nina, Markworth, James F, Figueiredo, Vandre C   +26 more
core   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

The macroenviromental control of cancer metabolism by p62 [PDF]

Cell Cycle, 2018
Metabolic reprogramming is a hallmark of cancer, but most studies focus on the molecular alterations in cancer cells and much less is known on the role of cancer metabolism, from a holistic perspective, for tumor initiation and progression. Increasing epidemiological evidence highlights the tremendous impact that cancer progression has on the host ...
Jianfeng, Huang, Maria T, Diaz-Meco, Jorge, Moscat   +2 more
openaire   +2 more sources

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

ULK1 phosphorylates p62 at S409.

, 2015
A.-C. In vitro p62 phosphorylation assay by ULK1 with purified MBP-p62 WT or mutant proteins. Bacterially expressed MBP-p62 was purified and then MBP tag was cleaved by Factor Xa.
Mondira Kundu (696499), Young J. Oh (696500), Shuai Wu (401994), Junghyun Lim (696497), M. Lenard Lachenmayer (696498), Rong Wang (59795), Wenchao Liu (330964), Yanxiang Zhao (638440), Masaaki Komatsu (233763), Zhenyu Yue (198875)   +9 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Salmonella Typhimurium infection: Type I Interferons integrate cellular networks to disintegrate macrophages

Cell Stress, 2018
Type I interferons have immunomodulatory functions during infection with bacteria and viruses. They are vital for the host defense against viruses and extracellular bacteria. However, recent evidences show that IFN-I contributes to immunopathology during
Nirmal Robinson
doaj   +1 more source

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

To aggregate or not to aggregate? A new role for p62 [PDF]

EMBO reports, 2009
Cell signalling is carried out by selective and complex metabolic networks that, when impaired, result in disease. The challenge for the cell is to maintain fidelity during normal processes, while allowing the plasticity that is required to control the complicated machinery of a functional cell.
Jorge, Moscat, Maria T, Diaz-Meco
openaire   +2 more sources