Results 81 to 90 of about 63,564 (302)
, 2017 A, B) p62 immunoreactivity was induced on one side of the ventral midbrain. White rectangle in (A) shows the area of enlargement in (B). C, D) The overexpression induced numerous inclusions within the transduced neurons. E, F) Visualization of inclusions
Wen-Lang Lin (530295) +8 more
core +1 more source
O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer
Advanced Science, EarlyView.This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu +10 more
wiley +1 more source
p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration. [PDF]
PLoS ONE, 2017 One of the proteins most frequently found in neuropathological lesions is the ubiquitin binding protein p62 (sequestosome 1). Post-mortem analysis of p62 is a defining diagnostic marker in several neurodegenerative diseases including amyotrophic lateral ...
Kasey L Jackson +8 more
doaj +1 more source
, 2016 A. HEK 293T cells were transiently co-transfected with FLAG-tagged p62 (FLAG-p62), c-myc-tagged LRRK2 (myc-LRRK2), or both. Twenty-four hours after transfection, total cell lysates were subjected to immunoprecipitation with anti-c-myc monoclonal antibody
Seulki Han (3121518) +6 more
core +1 more source
Sequestosome 1/p62 enhances chronic skin inflammation
, 2021 Background: The molecular control of inflammation and epidermal thickening in skin lesions of patients with atopic dermatitis (AD) is not known. Sequestosome 1/p62 is a multifunctional adapter protein implicated in the control of key regulators of ...
Sukseree, Supawadee +7 more
core +1 more source
Advanced Science, EarlyView.This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang +16 more
wiley +1 more source
Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis
Advanced Science, EarlyView.In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley +1 more source
p62 positively regulates autophagic flux.
, 2017 LC3II/I ratio and p62 protein levels in cell lysates were examined by Western blot for (A) ARPE-19 cells, transfected with p62 specific siRNA or scrambled siRNA (10nM) for 24h and treated with 400μM H2O2 for additional 24 h.
Colin S. Ip (3769606) +13 more
core +1 more source
Advanced Science, EarlyView.FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong +10 more
wiley +1 more source
Trehalose protects against oxidative stress by regulating the Keap1–Nrf2 and autophagy pathways
Redox Biology, 2018 Dysfunction of autophagy, which regulates cellular homeostasis by degrading organelles and proteins, is associated with pathogenesis of various diseases such as cancer, neurodegeneration and metabolic disease.
Yuhei Mizunoe +10 more
doaj +1 more source