Results 91 to 100 of about 63,564 (302)

RIPK3 regulates p62–LC3 complex formation via the caspase-8-dependent cleavage of p62 [PDF]

Biochemical and Biophysical Research Communications, 2015
RIPK3 is a key molecule for necroptosis, initially characterized by necrotic cell death morphology and the activation of autophagy. Cell death and autophagic signaling are believed to tightly regulate each other. However, the associated recruitment of signaling proteins remains poorly understood.
Yu, Matsuzawa, Shigeru, Oshima, Yoichi, Nibe, Masanori, Kobayashi, Chiaki, Maeyashiki, Yasuhiro, Nemoto, Takashi, Nagaishi, Ryuichi, Okamoto, Kiichiro, Tsuchiya, Tetsuya, Nakamura, Mamoru, Watanabe   +10 more
openaire   +2 more sources

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

p62/SQSTM1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy

FEBS Open Bio, 2018
Autophagy is a bulk degradation pathway, and selective autophagy to remove foreign entities is called xenophagy. The conjugation of ubiquitin to target pathogens is an important process in xenophagy but when and where this ubiquitination occurs remains ...
Megumi Tsuchiya, Hidesato Ogawa, Takako Koujin, Chie Mori, Hiroko Osakada, Shouhei Kobayashi, Yasushi Hiraoka, Tokuko Haraguchi   +7 more
doaj   +1 more source

p62/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-κB activation

Journal of Nanobiotechnology, 2020
Background Most nanoparticles (NPs) reportedly block autophagic flux, thereby upregulating p62/SQSTM1 through degradation inhibition. p62 also acts as a multifunctional scaffold protein with multiple domains, and is involved in various cellular processes.
Yifan Wu, Yang Jin, Tianyu Sun, Piaoyu Zhu, Jinlong Li, Qinglin Zhang, Xiaoke Wang, Junkang Jiang, Gang Chen, Xinyuan Zhao   +9 more
doaj   +1 more source

p62 specifically interacts with HDAC6.

, 2013
(A) Lysates of HEK cells transfected or not with HA-HDAC6 were subjected to GST-p62 pulldown assay. Tagged constructs were captured on glutathione sepharose beads and analyzed by Western blot with anti-HA and anti-GST antibodies.
Maria-Theresa Diaz-Meco (464029), Jianxiong Jiang (464031), Michael Lamar Seibenhener (464027), Michael C. Wooten (464033), Jin Yan (193119), Jorge Moscat (464030), Luis Calderilla-Barbosa (464028), Marie W. Wooten (464032)   +7 more
core   +1 more source

Oxidation of p62 as an evolutionary adaptation to promote autophagy in stress conditions [PDF]

, 2018
Ageing and age-related diseases are characterised by increased oxidative and proteotoxic stress, which results in negative effects on cell function and survival.
Rhoda Stefanatos, Elsje G. Otten, Viktor I. Korolchuk, Bernadette Carroll   +3 more
core   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Immunohistochemical expression in idiopathic inflammatory myopathies at a single center in Vietnam [PDF]

Journal of Pathology and Translational Medicine
Background The identification of idiopathic inflammatory myopathies (IIMs) requires a comprehensive analysis involving clinical manifestations and histological findings.
Dat Quoc Ngo, Si Tri Le, Khanh Hoang Phuong Phan, Thao Thi Phuong Doan, Linh Ngoc Khanh Nguyen, Minh Hoang Dang, Thien Thanh Ly, Thu Dang Anh Phan   +7 more
doaj   +1 more source

EXPRESSION AND PURIFICATION OF HUMAN p62 (HIS-TEV-mCherry-p62) v1

, 2023
This protocol describes how to express and purify human p62 tagged N-terminally with HIS and TEV. The expression is performed with E. coli Rosetta pLysS cells. The protein is purified via a HisTrap column and gel filtration (SEC).
openaire   +1 more source

Knock down of SPBP impairs p62 expression and sulforaphane induced p62 body formation.

, 2014
(A) Endogenous SPBP and p62 are coexpressed in several cell lines. Extracts of the indicated human cell lines were analysed by western blotting using the indicated antibodies. (B) siRNA mediated knock down of SPBP reduces p62 expression level. HeLa cells
Eva Sjøttem (8255), Sagar Ramesh Darvekar (507965), Julianne Elvenes (205103), Hanne Britt Brenne (507966), Terje Johansen (25018)   +4 more
core   +1 more source