Results 101 to 110 of about 63,564 (302)
Advanced Science, EarlyView.NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang +12 more
wiley +1 more source
Hypothalamic P62 (SQSTM1) regulates energy balance by modulating leptin signaling
Rationale: The multifaceted functions of p62 (SQSTM1) are increasingly recognized, but its role in hypothalamic metabolism-associated neurons for energy balance has yet to be elucidated. Methods: Single-nucleus RNA sequencing (snRNA-Seq) was performed on
Yang, S +10 more
core +1 more source
Advanced Science, EarlyView.This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang +14 more
wiley +1 more source
Stability of LRRK2 is regulated by p62.
, 2016 A. HEK 293T cells were transfected with 0.25, 0.5, or 1.0 μg FLAG-p62 expression plasmid or control vector for 24 h. Bafilomycin A1 was treated for 2 h.
Seulki Han (3121518) +6 more
core +1 more source
Advanced Science, EarlyView.HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang +10 more
wiley +1 more source
ULK1-mediated phosphorylation of p62 at S409 enhances p62 and Ub binding affinity.
, 2015 A. P-S409 enhances binding between p62 and poly-Ub proteins. Cellular lysates of p62 KO MEFs stably expressing empty vector, FLAG-p62 WT, S409A, or S409E were incubated with p62 KO MEFs lysates treated with MG132 and subsequently subjected to IP using ...
Mondira Kundu (696499) +9 more
core +1 more source
Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice
Advanced Science, EarlyView.Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li +5 more
wiley +1 more source
, 2014 Original Western blots of protein content of p62 in myocardial biopsies obtained at baseline (BL) before initiation of cardiopulmonary bypass and at 5–10 min reperfusion (R10) from patients undergoing remote ischemic preconditioning (RIPC) or not ...
Nilgün Gedik (559409) +6 more
core +1 more source
Advanced Science, EarlyView.A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li +5 more
wiley +1 more source
Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer. [PDF]
, 2016 Autophagy is a cellular degrading process that promotes tumor cell survival or cell death in cancer, depending on the progress of oncogenesis. Protein light chain 3 (LC3) and p62/SQSTM1 (p62) are associated with autophagosomal membranes that engulf ...
Schmid, Ralph +10 more
core +1 more source