Results 121 to 130 of about 96,733 (290)
Annals of Neurology, EarlyView.Objective Pathogenic variants in GNAO1 cause a spectrum of epilepsy, movement disorders, and developmental impairment. Clinical heterogeneity complicates prognosis and therapeutic development. We present the first longitudinal natural history study of GNAO1‐related disorders (GNAO1‐RD) to delineate phenotypic trajectories. Methods Sixty‐six individuals
Jana Domínguez‐Carral +52 more
wiley +1 more source
Virology JournalUsutu virus (USUV) is an emerging orthoflavivirus, which mainly affects birds but in rare cases can cause severe neuroinvasive disease in humans. The virus relies on a multitude of host cell proteins, molecules and cellular processes for its replication,
Tessa Nelemans +6 more
doaj +1 more source
The Role of the Ubiquitin-Proteasome System and p62 in the Development of Neurodegenerative Disease [PDF]
Impulse: The Premier Undergraduate Neuroscience Journal, 2006 The ubiquitin-proteasome system (UPS) is the pathway for degradation of nuclear and cytosolic proteins that are aged, damaged, or misfolded. Malfunctions in the UPS have been implicated in a wide variety of neurodegenerative diseases. Some proteins, when
Michael G. Paine, Marie W. Wooten
doaj
Scientific Reports, 2017 Adiponectin possesses potent anti-inflammatory properties. p62, an adaptor protein composed of multi-functional domain, is known to play a role in controlling inflammatory responses.
Nirmala Tilija Pun, Pil-Hoon Park
doaj +1 more source
Animal Research and One Health, EarlyView.Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao +12 more
wiley +1 more source
Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy [PDF]
, 2018 Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse ...
Manjili, Masoud H.
core +1 more source
Formation of high molecular weight p62 by CORM-3.
PLoS ONE, 2019 CORM-3 is a water-soluble carbon monoxide (CO)-releasing molecule developed for possible therapeutic use of CO. CORM-3 belongs to a group of metal carbonyl compounds that contain transition metals and carbonyls as the central scaffold and coordinated ...
Toshihiko Aki +5 more
doaj +1 more source
Animal Research and One Health, EarlyView.Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu +8 more
wiley +1 more source
SQSTM1/p62 interacts with FKBP38 and regulates cell cycle in Cashmere goat foetal fibroblasts
Journal of Applied Animal Research, 2018 SQSTM1 (sequestosome 1, also known as p62) is a multifunctional scaffold protein implicated in diverse cell physiology processes, such as autophagy, cell signalling, and protein turnover.
Qiburi He +9 more
doaj +1 more source
Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment
BMEMat, EarlyView.Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan +8 more
wiley +1 more source