Results 131 to 140 of about 63,564 (302)

Analysis of p62-UBA interacting proteins [PDF]

, 2006
Sequestosome 1/p62 interacts with and traffics K63-polyubiquitinated proteins through its ubiquitin associating domain (UBA). Herein we demonstrate that the hyperaccumulation of K63-polyubiquitinated proteins occurs in the absence of p62 making knock-out
Hu, Xiao
core  

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

Interdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang, Fan Zou, Mingdong Wang, Chenyue Wu, Yingwei Xie, Yongjun Quan, Wei Yan, Yupeng Zheng, Lianhua Li, Yuexin Liu, Jian Yu, Hao Ping   +11 more
wiley   +1 more source

Porcine reproductive and respiratory syndrome virus nsp5 inhibits the activation of the Nrf2/HO-1 pathway by targeting p62 to antagonize its antiviral activity

Journal of Virology
Porcine reproductive and respiratory syndrome virus (PRRSV) infections often trigger oxidative stress and cytokine storms, resulting in significant tissue damage that causes fatalities in piglets and reproductive issues in sows.
Fang Wang, Fructueux Modeste Amona, Yipeng Pang, Qiaoya Zhang, Yuan Liang, Xiaohan Chen, Yongding Ke, Junhao Chen, Chengchuang Song, Yanhong Wang, Zongyun Li, Chunlei Zhang, Xingtang Fang, Xi Chen   +13 more
doaj   +1 more source

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary‐Focused Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin, Marwa Tawfıq Ahmed Alsalım, Muhammed Canik, Sevda Bağdatlı, Nazan Deniz Yön   +4 more
wiley   +1 more source

The Human p62 cDNA Encodes Sam68 and Not the RasGAP-Associated p62 Protein [PDF]

Cell, 1996
Lock, Peter, Fumagalli, Stefano, Polakis, Paul, McCormick, Frank, Courtneidge, Sara A.   +4 more
openaire   +2 more sources

Bridging Nature and Counselor Education: Utilization and Barriers to EcoWellness

The Journal of Humanistic Counseling, EarlyView.
ABSTRACT Guided by an ecological–humanistic and existential–humanistic perspective, we explored EcoWellness as a form of nature‐based self‐care in counselor education by examining its associations with demographic characteristics, patterns of nature use, and self‐reported barriers among 193 students and faculty from CACREP‐accredited counseling ...
Brett Gleason, Ryan F. Reese, Heather Dahl‐Jacinto, Taylor Milner   +3 more
wiley   +1 more source

Cytotoxic Activity of Sicilian Red- and White-Grape Seed Oils on Human Liver and Colorectal Cancer Cells

Molecules
Seed oils from Sicilian white (WGSO) and red grapes (RGSO) were examined for their possible cytotoxic effect on HepG2 liver and CaCo-2 colorectal cancer cells, the latter also induced to intestinal differentiation. Half maximal inhibitory dilution (ID50)
Daniela Ganci, Giulia Abruscato, Roberto Chiarelli, Manuela Mauro, Vincenzo Arizza, Mirella Vazzana, Claudio Luparello   +6 more
doaj   +1 more source

Ubiquitin binding by the p62 UBA domain [PDF]

, 2013
Over 30 different mutations in p62 USA have been identified in patients with Paget's disease of bone (PDB). The mechanisms which underlie POB are poorly understood, although impaired ubiquitin binding has been identified as a mechanism in the onset of ...
Adlington, Jennifer
core  

Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng, Ling‐Li Chang, Hung‐Chen Wang, Wei‐Chun Hung, Chia‐Hua Hsieh, Yi‐Hsuan Wang, Kuang‐I Cheng   +6 more
wiley   +1 more source

稳定过表达外源p62/SQSTM1基因的U937白血病细胞株的建立及初步特性分析

Zhongshan Daxue xuebao. Yixue kexue ban, 2015
摘 要: 【目的】 构建稳定过表达外源p62/SQSTM1基因的人急性单核细胞白血病U937细胞株,并初步分析过表达p62基因对U937细胞的影响?【方法】 首先在空载体MSCV-IRES-GFP(MIG)基础上构建重组质粒MSCV-p62-IRES-GFP(MPIG),分别用MIG及MPIG载体进行病毒包装,并感染U937细胞,用流式细胞分选仪分选出绿色荧光细胞,获得U937-GFP和U937-p62稳定细胞株,利用流式细胞仪及Western blot分别检测GFP细胞的阳性率及p62蛋白表达水平 ...
doaj