Results 111 to 120 of about 63,564 (302)

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Mapping the interaction region on p62.

, 2013
(A) Schematic diagram of HA-tagged p62 deletion constructs. (B) HEK cells were transfected with full length FLAG-HDAC6 and HA-tagged p62 deletion mutants constructs. Full length p62 was myc-tagged.
Maria-Theresa Diaz-Meco (464029), Jianxiong Jiang (464031), Michael Lamar Seibenhener (464027), Michael C. Wooten (464033), Jin Yan (193119), Jorge Moscat (464030), Luis Calderilla-Barbosa (464028), Marie W. Wooten (464032)   +7 more
core   +1 more source

p62/SQSTM1 interacts with vimentin to enhance breast cancer metastasis [PDF]

, 2017
The signalling adaptor p62 is frequently overexpressed in numerous cancer types. Here, we found that p62 expression was elevated in metastatic breast cancer and its overexpression correlated with reduced metastasis-free and relapse-free survival times ...
Bugeon, Yao, S, Dallman, M, Bella, L, Lam, EW   +4 more
core   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Autophagy Suppresses Tumorigenesis through Elimination of p62

, 2009
SummaryAllelic loss of the essential autophagy gene beclin1 occurs in human cancers and renders mice tumor-prone suggesting that autophagy is a tumor-suppression mechanism.
Bray, Kevin, Mathew, Robin, Beaudoin, Brian, Gelinas, Celine, Chen, Hsin-Yi, Bhanot, Gyan, Vuong, Nhan, Chen, Guanghua, Karantza-Wadsworth, Vassiliki, Reddy, Anupama, White, Eileen, Karp, Cristina M., DiPaola, Robert S.   +12 more
core   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Drug repositioning identifies potential autophagy inhibitors for the LIR motif p62/SQSTM1 protein

MA.M. is supported by international (project on drug repositioning for LC3-interacting region of autophagy protein p62/SQSTM1 in breast cancer) and national (No.
Cordani, Marco, Nayeri, Zahra, Asghari, Narjes, Moosavi, Mohammad Amin, Saei, Ali Kian   +4 more
core   +1 more source

Apaf-1 interacts with p62.

, 2019
(A, B) Co-immunoprecipitation was performed following the transfection of apaf-1-HA and p62-FLAG into HEK293T cells. Apaf-1 interacted with p62 (A).
Kazunori Ohta (3373331), Tomomi Sunayama (7022603), Eri Ohta (7022576), Masashi Endo (7022606), Toshiyuki Nakagawa (7022612), Tana (7022597), Miao-xing Wang (7022585), Miki Hayakawa-Ogura (7022588), Saiful Islam (157612), Masashi Ueda (492831), Yoko Hida (7022582), Kiyomi Nakagawa (7022600), Emika Nishida (7022594), Yoya Ohno (7022609), Masanori Itoh (7022579), Huayue Chen (359130), Shimo Li (7022591), So Hirata (1390211)   +17 more
core   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source