Results 141 to 150 of about 54,852 (260)

Exploring cannabinoid receptor CB1 autophagy and the obesity phenotype of p62-deficient mice. [PDF]

Biochem Biophys Rep
Keller C, Rading S, Candur B, Bindila L, Loers G, Karsak M.   +5 more
europepmc   +1 more source

From Conflicting Outcomes to Mutual Losses: How Punitive Responses to Problematic Substance Use Suppress Help‐Seeking and Cause Harm

Human Resource Management Journal, EarlyView.
ABSTRACT Problematic substance use (PSU) is a significant, inadequately managed people management challenge. Drawing on the conflicting outcomes and mutual losses perspectives on HRM and employee wellbeing, and using Job Demands‐Resources theory to explain underlying strain‐driven loss cycles, we examine factors shaping PSU and help‐seeking among 575 ...
Karen Maher, Aoife M. McDermott, Andrew Clements, Emmert Roberts, Sally Pezaro   +4 more
wiley   +1 more source

Deciphering the Neuroautophagic Interactome: Molecular Circuits Linking Selective Autophagy to Neuropathological Cascades in Neurological Disorders. [PDF]

Int J Biol Sci
Luo P, Travis ZD, Lenahan C, Wu H, Zhang J, Yu J, Xu W.   +6 more
europepmc   +1 more source

Amphibian‐Derived Peptide OA‐AL14 Alleviates UVB‐Induced Skin Photoaging via Autophagy Activation Mediated by the AMPK/mTOR Pathway

Integrative Zoology, EarlyView.
The schematic diagram illustrates that the amphibian‐derived peptide OA‐AL14 protects against UVB‐induced skin photoaging through a dual mechanism: activating the Nrf2 pathway to counteract oxidative stress and modulating the AMPK/mTOR axis to induce protective autophagy. ABSTRACT Skin photoaging, primarily driven by ultraviolet B (UVB) radiation, is a
Ying Peng, Yutong Wu, Zhe Fu, Zijian Kang, Qiuye Jia, Wenbi Zhao, Ziyi Wang, Yuexi Liu, Ruijie Zhang, Yuansheng Li, Zeqiong Ru, Wenrou Su, Naixin Liu, Yilin Li, Saige Yin, Ying Wang, Xinwang Yang   +16 more
wiley   +1 more source

Butyrate protects against Klebsiella pneumoniae-induced oxidative stress in alveolar macrophages via p62-Keap1-Nrf2 pathway. [PDF]

Redox Biol
Meng B, Li H, Tang M, Zhu J, Yao R, Xu Y, Zhang Q, Zhu R, Guo Y, Xu Y, Shu Y, Yu L, Li Y, Yang Y, Liu Y, Wu T, Li J.   +16 more
europepmc   +1 more source

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, EarlyView.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

Regulation of Innate Immune Signaling by Autophagy. [PDF]

Int J Mol Sci
Oña-Sánchez D, Bandera-Linero J, Pimentel-Muiños FX.   +2 more
europepmc   +1 more source

Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space

Brain Pathology, EarlyView.
In a mixed diagnostic cohort of pathologically diagnosed Alzheimer's disease, cerebrovascular disease, mixed pathology, and control tissue, we connected the histopathological wasteosome profile in periventricular (PV) brain sections to 7T FLAIR‐MRI confirmed PV white matter hyperintensities (WMHs), vascular stenosis and perivascular space size ...
Nikita Ollen‐Bittle, Isabella Boesgaard, Austyn Roseborough, Meaghan Frank, Qi Zhang, Stephen H. Pasternak, Robert Hammond, Shawn N. Whitehead   +7 more
wiley   +1 more source

Effects of β‑hydroxybutyrate on restoring autophagic flux and mitochondrial function in macrophages exposed to oxidized low‑density lipoprotein. [PDF]

Mol Med Rep
Luo W, He M, Wang H.
europepmc   +1 more source

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies

Brain Pathology, EarlyView.
Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom, Pawel Palmowski, Andrew Porter, Joe O'Neill, Johannes Attems, Laura A. Smith, Viktor I. Korolchuk, Daniel Erskine   +7 more
wiley   +1 more source