Results 161 to 170 of about 96,733 (290)

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

The Effects of the Economic Crisis on the Older Population [PDF]

We study the effects of the 2007-2009 recession on the population age 55 and older. Households in and near retirement have suffered sizeable losses in assets as a result of the economic crisis. There are a number of ways in which households might respond:
Michael D. Hurd, Susann Rohwedder
core  

Exploring cannabinoid receptor CB1 autophagy and the obesity phenotype of p62-deficient mice. [PDF]

Biochem Biophys Rep
Keller C, Rading S, Candur B, Bindila L, Loers G, Karsak M.   +5 more
europepmc   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Butyrate protects against Klebsiella pneumoniae-induced oxidative stress in alveolar macrophages via p62-Keap1-Nrf2 pathway. [PDF]

Redox Biol
Meng B, Li H, Tang M, Zhu J, Yao R, Xu Y, Zhang Q, Zhu R, Guo Y, Xu Y, Shu Y, Yu L, Li Y, Yang Y, Liu Y, Wu T, Li J.   +16 more
europepmc   +1 more source

Developmental expression of Ap‐Vas proteins in aphids and flies reveals their evolutionary roles in insects

Insect Molecular Biology, EarlyView.
Duplication of vas genes is universally observed in aphids, and phylogenetic analysis indicates that this event predates the divergence of Aphididae and Phylloxeridae. Ap‐vas1 is germline‐specific, whereas Ap‐vas2–4 exhibit somatic expression, indicating functional divergence during aphid embryogenesis.
Gee‐Way Lin, Szu‐Chieh Wang, Charles E. Cook, Ming‐Der Lin, Chun‐che Chang   +4 more
wiley   +1 more source

Mature-onset obesity in p62-deficient male mice maintains skeletal muscle mass despite metabolic dysfunction. [PDF]

Physiol Rep
Kim DH, Salazar G, Klemp A, Hwang HS, Yeh M, Panton LB, Kim JS.   +6 more
europepmc   +1 more source

Assessing inconsistencies in the FITradeoff method: a comparison of two preference modeling paradigms

International Transactions in Operational Research, EarlyView.
Abstract Many decision‐making processes are susceptible to errors and inconsistencies introduced by decision‐makers (DMs). The development of decision support systems (DSS) has brought about a way to guide DMs through complex decision scenarios. However, due to the complexity of the process, inconsistencies may still arise.
Evanielle Barbosa Ferreira, Lucia Reis Peixoto Roselli, Adiel Teixeira de Almeida   +2 more
wiley   +1 more source

P62 in colorectal cancer: from inflammation suppression to cancer promotion. [PDF]

Front Immunol
A N, Huang J, Liu L, Chen H, Chen J, Zou S, Pang Y, Wu X, Liu M, Liang G.   +9 more
europepmc   +1 more source

Ubiquitin-induced phase separation of p62/SQSTM1 [PDF]

Cell Research, 2018
Lina, Herhaus, Ivan, Dikic
openaire   +2 more sources