Results 181 to 190 of about 54,852 (260)

A live‐cell autophagy reporter reveals reversible vacuolation in naked mole‐rat skin fibroblasts under lysosomal stress

The FEBS Journal, EarlyView.
A tandem fluorescent mCherry–EGFP–LC3 reporter enables live‐cell visualisation of autophagy–lysosome dynamics in naked mole‐rat skin fibroblasts. Chloroquine‐induced lysosomal stress promotes accumulation of neutral LC3‐positive compartments and triggers pronounced LC3‐associated vacuolation.
Fangze Tong, Mateo P. Hoare, Laura J. Grundy, Filomena Gallo, Karin H. Müller, Ewan St. John Smith, Janet R. Kumita   +6 more
wiley   +1 more source

Arsenic-Induced PPARγ, with the Coordinated Action of p62, Inhibits Apoptosis and Necroptosis and Activates the DNA Damage Response in A549 Lung Cancer Cells, Leading to Carcinogenesis. [PDF]

Cells
Kim HR, Oh SH.
europepmc   +1 more source

Diagnostic utility of inflammatory markers in formalin‐fixed and paraffin‐embedded muscle biopsies for idiopathic inflammatory myopathies

Histopathology, EarlyView.
Formalin‐fixed, paraffin‐embedded (FFPE) muscle tissue supports robust immunohistochemical detection of MHC II, MxA, and p62 with performance comparable to frozen sections. This approach reliably identifies the pathological signatures of inclusion body myositis, dermatomyositis, immune‐mediated necrotizing myopathy, and overlap myositis, enhancing the ...
Chinnawut Suriyonplengsaeng, Jariya Waisayarat   +1 more
wiley   +1 more source

Duck plague virus US2 promotes p62-mediated autophagic degradation of RIG-I to suppress antiviral signaling. [PDF]

Poult Sci
Hao Y, Xiong M, Wang M, Cheng A.
europepmc   +1 more source

Assessing inconsistencies in the FITradeoff method: a comparison of two preference modeling paradigms

International Transactions in Operational Research, EarlyView.
Abstract Many decision‐making processes are susceptible to errors and inconsistencies introduced by decision‐makers (DMs). The development of decision support systems (DSS) has brought about a way to guide DMs through complex decision scenarios. However, due to the complexity of the process, inconsistencies may still arise.
Evanielle Barbosa Ferreira, Lucia Reis Peixoto Roselli, Adiel Teixeira de Almeida   +2 more
wiley   +1 more source

Ubiquitin ligase ITCH regulates life cycle of SARS-CoV-2 virus. [PDF]

Elife
Xiang Q, Wouters C, Chang P, Lu YN, Liu M, Wang H, Heine H, Qian S, Yang J, Pekosz A, Zhang Y, Wang J.   +11 more
europepmc   +1 more source

Bone biology in aging periodontal and peri‐implant tissues

Periodontology 2000, EarlyView.
Abstract Background Periodontal disease is an age‐related chronic inflammatory condition leading to tooth loss. Dental implants are an option for replacement of lost teeth in older adults. However, age‐related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.
Dalia Rasheed Issa, Giuseppe Intini, Daniel Clark   +2 more
wiley   +1 more source

Astaxanthin alleviates autophagy, inflammation, and oxidative stress in ventilator-associated lung injury rats by inhibiting MAPK/ERK1/2 pathway. [PDF]

Acta Cir Bras
Zhang J, Wei Y, Chen Z, Luo T, Cheng S, Wang J, Zhang X.   +6 more
europepmc   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions. [PDF]

Mol Med Rep
Xie C, Liu Z, Chen T, Lu H, Zhang X, Yu W, Zhang J, Shang D, Wang X.   +8 more
europepmc   +1 more source