Results 171 to 180 of about 96,733 (290)

Bone biology in aging periodontal and peri‐implant tissues

Periodontology 2000, EarlyView.
Abstract Background Periodontal disease is an age‐related chronic inflammatory condition leading to tooth loss. Dental implants are an option for replacement of lost teeth in older adults. However, age‐related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.
Dalia Rasheed Issa, Giuseppe Intini, Daniel Clark   +2 more
wiley   +1 more source

The lysine methyltransferase KMT5a and p53 regulate the expression of the key autophagy adaptor p62/SQSTM1 in glioblastoma. [PDF]

Cell Commun Signal
Della Monica R, Buonaiuto M, Cuomo M, Drongitis D, Miano MG, Costabile D, de Riso G, Trio F, Sabbarese M, Ferraro S, Oliva L, Piacentino N, Cappiello R, Scotti G, Lasorsa VA, Capasso M, De Bellis A, Del Basso De Caro M, Chiariotti L, Visconti R.   +19 more
europepmc   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

Applying lessons from limb muscle disuse and ageing to better understand ventilator‐induced diaphragm dysfunction

Experimental Physiology, EarlyView.
Abstract Mechanical ventilation (MV) is a life‐saving intervention applied to critically ill patients. A common consequence of MV is ventilator‐induced diaphragm dysfunction (VIDD), which is characterized by significant diaphragm atrophy and reduced contractile function. Older patients who receive MV are more likely to develop VIDD, have worse recovery,
P. H. C. Mesquita, J. L. Halle, J. D. Fuqua, B. F. Miller   +3 more
wiley   +1 more source

NRF2 controls a diverse network of antiviral effectors with p62 acting as a central restriction factor effective across virus families. [PDF]

Redox Biol
Pedersen A, Blay-Cadanet J, Storgaard J, Hernaez B, Thyrsted J, Bach-Nielsen CS, Twayana K, Jørgensen SE, Rio-Bergé C, Poulsen C, Thielke AL, Thomsen EA, Kalucka J, Olagnier D, Luo Y, Reggiori F, Mogensen TH, Alcamí A, Hansen AL, Holm CK.   +19 more
europepmc   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

Metformin attenuates TBHP-induced oxidative injury in human lens epithelial cells and is associated with SIRT1/FOXO1-related autophagy. [PDF]

PLoS One
Yan Z, Chi W, Yan Z, Wang H.
europepmc   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice [PDF]

, 2017
Aagaard, Barrows, Bayer, Bin Cao, Cadwell, Cao, Cao, Cao-Lormeau, Cemma, Chibueze, Chiramel, Delorme-Axford, Delvecchio, El Costa, Elfiky, Eyer, Farias, Hamel, Indira U. Mysorekar, Jurado, Kaplan, Khan, Klionsky, Lamont, Lennemann, Levine, Liang, Lindsay A. Parnell, Martín-Acebes, Mateo, Michael S. Diamond, Miner, Mysorekar, Pirooz, Quicke, Rosenfeldt, Rossant, Sacramento, Savarino, Sharma, Shoji-Kawata, Signorelli, Tabata, Tricou, Vandergaast, Vermillion, Wenzel, Xu, Yockey, Zmurko   +49 more
core   +2 more sources

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto, Phung N. Thai, Gabriela Grigorean, Veneese J. Brown, Tjien Dwyer, Nipavan Chiamvimonvat, Elena N. Dedkova, Saul Schaefer   +7 more
wiley   +1 more source