Results 171 to 180 of about 63,564 (302)

Autophagy Inhibition by Fangji Huangqi Decoction Enhances Tumor Immunogenicity and Potentiates PD‐1 Blockade

Cancer Science, EarlyView.
In tumor cells, MHC‐I is typically degraded through autophagy, leading to reduced antigen presentation. However, Fangji Huangqi Decoction (FJHQ), acting as an autophagy inhibitor, suppresses lysosomal acidification, which in turn inhibits the degradation of MHC‐I. This results in increased surface expression of MHC‐I on tumor cells.
Yuxiao Jiang, Shiji Zeng, Dingye Wang, Junbo Jiang, Zhenzhen Li, Jingbi Li, Dan Chen, Xu Zhao, Zheng Ying, Yuehua Deng, Qianwei Cai, Silin Mai, Jiayi Zheng, Qiaohong Yang, Fang Liu, Biaoyan Du, Jianyong Xiao, Xiaoyi Liu, Kun Wang   +18 more
wiley   +1 more source

Drug repositioning and experimental validation for targeting ZZ domain of p62 as a cancer treatment

This study was funded by the National Institute of Genetic Engineering and Biotechnology (NIGEB) (Grant no. 884), Tehran, Iran. M.C is supported by grant RYC2021-031003I funded by MICIU/AEI/10.13039/501100011033 and, by European Union NextGenerationEU ...
Jahangiri, Babak, Cordani, Marco, Djavaheri-Mergny, Mojgan, Nayeri, Zahra, Fard, Najaf Allahyari, Asghari, Narjes, Moosavi, Mohammad Amin, Saei, Ali Kian   +7 more
core   +1 more source

Differential regulation of p62-ubiquitin conjugates in neurons versus astrocytes during cellular stress. [PDF]

PLoS One
Sidibe DK, Smith EM, Spivey ML, Vogel MC, Maday S.   +4 more
europepmc   +1 more source

Elucidating the Pro‐Tumor Role of LncRNA CROCCP2 in Glioma via the miR‐5584‐5p/HOXD11/Autophagy Pathway

Cancer Science, EarlyView.
The lncRNA CROCCP2 upregulates HOXD11 by competitively adsorbing miR‐5584‐5p, thereby promoting glioma cell proliferation, migration, and invasion by inhibiting autophagy. It significantly enhances tumor growth in vivo, suggesting it may be a potential therapeutic target for gliomas.
Feng Wang, Ganni Lei, Yuan Peng, Maoqiao Liu, Tianqi Jiang, Minghui Wang, Zhe Wang, Jun Pu, Jia Liu   +8 more
wiley   +1 more source

The Discovery of p62-dependent Processing Bodies

The cellular degradation process autophagy can be a selective process during which, cellular components, such as excess proteins, can be marked for degradation by the post translational modification ubiquitination.
Barrow, Elizabeth
core  

An oral-gut microbial metabolite links <i>Fusobacterium nucleatum</i> to aggravated myocardial ischemia-reperfusion injury. [PDF]

Gut Microbes
Li Y, Xu Q, Zhu M, Wang W, Liu Y, Yang H, Liu Y.   +6 more
europepmc   +1 more source

Combined MEK1/2 and Autophagy Inhibition Suppresses Tumor Growth via STING‐Mediated Type I Interferon Response in iCCA

Cancer Science, EarlyView.
Through bioinformatic analyses, iCCA cell models, and in vivo xenograft experiments, we show that autophagy inhibition sensitizes iCCA to MEK1/2 blockade by enhancing STING‐dependent type I interferon signaling. These findings support combined MEK1/2 and autophagy inhibition as a promising therapeutic strategy for iCCA. ABSTRACT The RAF–MEK–ERK pathway
Chengqiang Sun, Zheng Gao, Enfu Dong, Liangxia Ding, Shanru Feng, Jiafeng Chen, Pascal Kwangwari, Yinghong Shi, Weiren Liu, Xin Zhang, Ao Huang, Jian Zhou, Sheng Wang, Jia Fan, Xiutao Fu, ZhenBin Ding   +15 more
wiley   +1 more source

The oncogenic signalosome: SQSTM1/p62 as a master integrator of signaling, metabolism, and autophagy in cancer. [PDF]

Toxicol Res
Choi EJ, Jeon SM.
europepmc   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Exploring cannabinoid receptor CB1 autophagy and the obesity phenotype of p62-deficient mice. [PDF]

Biochem Biophys Rep
Keller C, Rading S, Candur B, Bindila L, Loers G, Karsak M.   +5 more
europepmc   +1 more source