Results 191 to 200 of about 96,733 (290)

The E3 Ligase RNF8 Promotes Ubiquitination and Degradation of ChREBPα During Liver Stress Response

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
During MASH development, increasing hepatic stress signals, particularly a combination of lipotoxicity (palmitate) and inflammation (TNFα), trigger JNK, the key stress‐activated protein kinase. Activated JNK recruits RNF8, a stress‐induced E3 ligase, to promote ubiquitination and proteasomal degradation of the ChREBPα protein.
Yuee Zhao, Sujuan Wang, Jian Zhang, Sarah Cooke, Gary Zhang, Zifeng Zhao, Joon Oh, Xin Tong, Lei Yin   +8 more
wiley   +1 more source

p62/SQSTM1 Condensation Modulates Mitochondrial Clustering to Participate in Mitochondrial Quality Control. [PDF]

Aging Cell
Sun S, Xin J, Zhang Y, Yang B, Su D, Ni R, Ma Q, Li N, Ma G, Peng Q, Chen S, Prehn JHM, Tam KY, Wang H, Ying Z.   +14 more
europepmc   +1 more source

VGLL3 Regulates DAPK2‐Mediated Autophagy During Osteoblast Differentiation

BioFactors, Volume 52, Issue 3, May/June 2026.
VGLL3 regulates autophagic activity during osteoblast differentiation and is associated with DAPK2‐mediated autophagy. Overexpression of Dapk2 partially restores autophagy and osteogenic differentiation in Vgll3‐deficient osteoblasts. ABSTRACT Vestigial‐like family member 3 (VGLL3), a transcriptional cofactor of the TEA domain family, has been ...
Yuhan He, Ziyi Wang, Yao Weng, Heriati Sitosari, Yilin Zheng, Yaxin Qu, Mika Ikegame, Hirohiko Okamura   +7 more
wiley   +1 more source

Effect of <i>Moringa oleifera</i> Protein-Coated Gold Nanoparticles as Naturally Derived Disruptors of Biofilms. [PDF]

Int J Biomater
Menon LS, Ghosh N, Biswas S.
europepmc   +1 more source

Stanniocalcin 2‐Induced Autophagy Confers Resistance of Lung Cancer Cells to EGFR Inhibition via the ERK/Beclin 1 Signaling

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are effective in treating NSCLC with EGFR mutations, the development of resistance limits their long‐term efficacy. Autophagy has been implicated as a potential mechanism behind this acquired resistance.
Yi‐Nan Liu, Yi‐Ling Chen, Meng‐Feng Tsai, Shang‐Gin Wu, Tzu‐Hua Chang, Tzu‐Hsiu Tsai, Jin‐Yuan Shih   +6 more
wiley   +1 more source

Polystyrene Nanoplastics induced placental toxicology by activating Keap1-mediated ferroptosis via METTL3-dependent m6A methylation. [PDF]

Cell Biol Toxicol
Chen Y, Liu Y, Zhang M, Li S, Yan Y, Yin C.   +5 more
europepmc   +1 more source

Saikosaponin A Inhibits Migration/Invasion and Triggers Cell‐Cycle Arrest and Autophagy‐Induced Cell Death in HCT116 Cells and In Vivo

Food Frontiers, Volume 7, Issue 3, May 2026.
Saikosaponin A from Radix Bupleuri inhibited colorectal cancer HCT116 cells with low toxicity. SSA induced S/G2‐M cell cycle arrest and triggered autophagy via mTOR inhibition. SSA suppressed metastasis by blocking PI3K/AKT signaling pathway. SSA significantly reduced tumor growth without apparent toxicity.
Xiu‐Xiu Zhang, Wang‐Wei Zhang, Run‐Hui Ma, Zhi‐Jing Ni, Kiran Thakur, Mohammad Rizwan Khan, Jian‐Guo Zhang, Zhao‐Jun Wei   +7 more
wiley   +1 more source

Correction: Erythropoietin mitigates diabetic nephropathy by restoring PINK1/Parkin-mediated mitophagy. [PDF]

Front Pharmacol
Yi X, Yan W, Guo T, Liu N, Wang Z, Shang J, Wei X, Cui X, Sun Y, Ren S, Chen L.   +10 more
europepmc   +1 more source

Short‐Term Oral Spermidine Supplementation Modifies Aspects of Neurodegenerative Disease in Flies and Mice With MPS III

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Mucopolysaccharidosis type III (MPS III) is a group of autosomal recessive neurodegenerative lysosomal storage disorders that causes progressive cognitive and physical impairment, predominantly in child/early adulthood. The median age of death is 17 years as there is no safe, effective treatment approved.
Helen Beard, Sonia Dayan, Karissa Barthelson, Laura Hewson, Louise V. O'Keefe, Kim M. Hemsley   +5 more
wiley   +1 more source

Repurposing dronedarone induces ferroptosis through GPX4 inactivation and degradation in pancreatic cancer. [PDF]

J Exp Clin Cancer Res
Gu Y, Wang Y, Liu G, Cui R, Ma C, Wang J, Gao X, Zhao Y, Li Y.   +8 more
europepmc   +1 more source