Results 1 to 10 of about 38,748 (248)
The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity [PDF]
Journal of Biological Chemistry, 2021 Components of the autophagy machinery are subject to regulation by various posttranslational modifications. Previous studies showed that monoubiquitination of LC3B catalyzed by the ubiquitin-activating enzyme UBA6 and ubiquitin-conjugating enzyme ...
Rui Jia, Juan S Bonifacino
exaly +4 more sources
LC3B: A microtubule-associated protein influences disease progression and prognosis
Cytokine and Growth Factor ReviewsMicrotubule-associated protein 1 light chain 3B (MAP1LC3B, also known as LC3B) is a mammalian homolog of the autophagy-related protein 8 (ATG8) family.
Yan Chen +5 more
exaly +4 more sources
LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy
Developmental Cell, 2023 Lipid droplets (LDs) store lipids that can be utilized during times of scarcity via autophagic and lysosomal pathways, but how LDs and autophagosomes interact remained unclear.
Thomas J Melia +2 more
exaly +2 more sources
Autophagy, 2021 Mitophagy formed the basis of the original description of autophagy by Christian de Duve when he demonstrated that GCG (glucagon) induced macroautophagic/autophagic turnover of mitochondria in the liver.
Kay F Macleod +2 more
exaly +2 more sources
LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy
Nature Communications, 2022 LC3/ATG8 has long been appreciated to play a central role in autophagy, by which a variety of cytoplasmic materials are delivered to lysosomes and eventually degraded. However, information on the molecular functions of LC3 in RNA biology is very limited.
Hyun Jung Hwang +2 more
exaly +2 more sources
Cells, 2020 Macroautophagy is a conserved degradative process for maintaining cellular homeostasis and plays a key role in aging and various human disorders. The microtubule-associated protein 1A/1B light chain 3B (MAP1LC3B or LC3B) is commonly analyzed as a key ...
Marius W Baeken +2 more
exaly +2 more sources
Briefings in Bioinformatics, 2021 Coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, causing significant mortality. There is a mechanistic relationship between intracellular coronavirus replication and deregulated autophagosome–lysosome system.
Shisong Fang, Lin Zhang, Ziheng Huang
exaly +2 more sources
Bioactive Materials, 2022 Osteosarcoma (OS) therapy faces many challenges, especially the poor survival rate once metastasis occurs. Therefore, it is crucial to explore new OS treatment strategies that can efficiently inhibit OS metastasis.
G. He +10 more
semanticscholar +1 more source
Protein Science, 2023 Autophagy is a highly conserved cellular process that allows degradation of large macromolecules. p62/SQSTM1 is a key adaptor protein that interacts both with material to be degraded and with LC3 at the autophagosome, enabling degradation of cargos such ...
L. Alcober-Boquet +12 more
semanticscholar +1 more source