Results 31 to 40 of about 38,748 (248)
Inhibition LC3B can increase chemosensitivity of ovarian cancer cells [PDF]
Cancer Cell International, 2019 Ovarian cancer is often accompanied by the production of ascites, and patients with repeated ascites are associated with chemotherapy resistance. The previous study confirmed that the ovarian cancer patients who developed ascites after chemotherapy had elevated autophagy levels in the ascites and precipitated cells, which was positively correlated with
Jing Tang +13 more
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International Immunopharmacology, 2022 BACKGROUND Circulating extracellular vesicles (EVs) are recognized as a promising source of cancer biomarkers. We previously reported that tumor cell-released autophagosomes, a new subgroup of EVs expressing the mature autophagosome-specific marker LC3B (
Yongqiang Chen +9 more
semanticscholar +1 more source
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells [PDF]
, 2018 Sirtuin 6 (SIRT6) is a member of the NAD+-dependent class III deacetylase sirtuin family, which plays a key role in cancer by controlling transcription, genome stability, telomere integrity, DNA repair, and autophagy.
Annamaria Biroccio, And +13 more
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Significance Of LC3B Autophagy Marker In Recurrent Prostate Adenocarcinoma
Russian Open Medical Journal, 2022 Objective — To compare the expression of the LC3B autophagy marker before and after treatment with high-intensity focused ultrasound therapy (HIFU) and combined therapies: androgenic deprivation AD + HIFU, AD + radiation therapy in patients with and without recurrent prostate adenocarcinoma.
Elena S. Voronina +5 more
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Cellular and Molecular Life Sciences, 2022 In synapses that show signs of local apoptosis and mitochondrial stress and undergo neuro-immunological synapse pruning, an increase in the levels of the presynaptic protein, neuronal-specific septin-3 can be observed.
Vilmos Tóth +15 more
semanticscholar +1 more source
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates [PDF]
, 2019 The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear.
Abert, Christine +9 more
core +1 more source
Autophagy Assays (LC3B immunofluorescence, LC3B western blot, acridine orange assay)
BIO-PROTOCOL, 2013 Autophagy is a dynamic cellular event that is involved in the degradation of long lived proteins and organelles in cells. Biochemical methods such as western blot to measure autophagic proteins have been increasingly used in autophagy studies because it is convenient and objective.
Xin Zhang, Qingsong Liu
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CD36 and LC3B initiated autophagy in B cells regulates the humoral immune response
Autophagy, 2021 Scavenger receptors are pattern recognition receptors that recognize both foreign and self-ligands, and initiate different mechanisms of cellular activation, often as co-receptors.
Chenfei He +11 more
semanticscholar +1 more source
The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease [PDF]
, 2020 Objective Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD).
Alves, Sandro +12 more
core +1 more source
The LC3B FRET biosensor monitors the modes of action of ATG4B during autophagy in living cells
bioRxiv, 2022 Although several mechanisms of autophagy have been dissected in the last decade, following this pathway in real time remains challenging. Among the early events leading to its activation, the ATG4B protease primes the key autophagy player LC3B. Given the
Elif Begüm Gökerküçük +3 more
semanticscholar +1 more source