Results 41 to 50 of about 38,748 (248)

Proximity interactome of LC3B in normal growth conditions [PDF]

, 2021
AbstractLC3 (Light Chain 3) is a key player of autophagy, a major stress-responsive proteolysis pathway promoting cellular homeostasis. It coordinates the formation and maturation of autophagosomes and recruits cargo to be further degraded upon autophagosome-lysosome fusion.
Marie Nollet, Alexander Agrotis, Fanourios Michailidis, Arran David Dokal, Vinothini Rajeeve, Jemima Burden, Thomas D. Nightingale, Pedro Cutillas, Robin Ketteler, Stéphanie Kermorgant   +9 more
openaire   +1 more source

HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa [PDF]

, 2018
The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing.
A Criollo, A Hamacher-Brady, A Hamacher-Brady, A Rita Di, A Rita Di, A Rozenknop, A Sali, A Sprenger, A Stolz, A Tanaka, AY Abramov, B Richter, C Margreitter, D Knight, DW Choi, EM Valente, F Strappazzon, F Strappazzon, F Strappazzon, F Strappazzon, G Ashrafi, G Xu, GA Khoury, GP Leboucher, H Sandoval, H Tomita, H Zhou, I Matic, I Novak, J Kitchen, JJ Lemasters, JL Parsons, JM Heo, K Sugawara, K Yamano, L Liu, LA Kane, M Campanella, M Karbowski, M Laforge, M Lazarou, M Pasi, M Pilli, M Tiberti, M Tiberti, MJ Abraham, MP Williamson, N Bakkar, N Shembade, NC Chan, P Bjelkmar, P Wild, Q Zhong, RK Dagda, S Inoue, S Piana, T Kitada, T Murakawa, T Tatsuta, TN Nguyen, V Cianfanelli, VV Rogov, VV Rogov, VV Rogov, W Zhang, Y Chen, Y Ichimura, Y Wei, Y Xue, Y Yuan, Y Zhu   +70 more
core   +4 more sources

STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain

Journal of Cell Biology, 2020
A primordial function of the cGAS/STING pathway may be to induce LC3B lipidation. Fischer et al. show cGAMP-activated STING induces the V-ATPase to recruit ATG16L1 for lipidation of LC3B onto single-membrane perinuclear vesicles.
Tara D. Fischer, Chunxin Wang, B. Padman, M. Lazarou, R. Youle   +4 more
semanticscholar   +1 more source

DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose [PDF]

, 2015
Macroautophagy is a membrane-trafficking process that delivers cytoplasmic constituents to lysosomes for degradation. The process operates under basal conditions as a mechanism to turnover damaged or misfolded proteins and organelles. As a result, it has
A Kuma, A Stolz, AD Baudot, AM Choi, B Levine, B Levine, B Ravikumar, D Crighton, D Crighton, D Crighton, D Strachan, DJ Klionsky, DW Hailey, EL Axe, EL Eskelinen, F Beaumatin, F Corpet, H Harlin, I Kissova, J O'Prey, J O'Prey, J S Long, J Skommer, JJ Lemasters, JJ Lum, JS Long, K M Ryan, KM Ryan, KM Ryan, L Cong, L Y Lao, LA Bell, LY Mah, M Mrschtik, M O'Prey, MT Rosenfeldt, MT Rosenfeldt, N Mizushima, N Mizushima, P Boya, S Hehlgans, S Wilkinson, SA Tooze, SW Tait, Y Kabeya, Y Kamada, Y Ohsumi, Z Xie   +47 more
core   +2 more sources

Human cachexia induces changes in mitochondria, autophagy and apoptosis in the skeletal muscle [PDF]

, 2019
Cachexia is a wasting syndrome characterized by the continuous loss of skeletal muscle mass due to imbalance between protein synthesis and degradation, which is related with poor prognosis and compromised quality of life.
Alcantara, P. S., Coletti, D., de Castro, G. S., Festuccia, W. T., Lima, J. D. C. C., Ortiz-Silva, M., Otoch, J. P., Seelaender, M., Simoes, E., Tokeshi, F.   +9 more
core   +1 more source

Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity [PDF]

, 2014
During macroautophagy, conjugation of ATG12 to ATG5 is essential for LC3 lipidation and autophagosome formation. Additionally, ATG12 has ATG5-independent functions in diverse processes including mitochondrial fusion and mitochondrial-dependent apoptosis.
Debnath, Jayanta, Giampazolias, Evangelos, Green, Douglas R., Haller, Martina, Hock, Andreas K., Oberst, Andrew, Ryan, Kevin M., Tait, Stephen W. G., Vousden, Karen H.   +8 more
core   +7 more sources

Direct Interaction of ATP7B and LC3B Proteins Suggests a Cooperative Role of Copper Transportation and Autophagy

Cells, 2021
Macroautophagy/autophagy plays an important role in cellular copper clearance. The means by which the copper metabolism and autophagy pathways interact mechanistically is vastly unexplored.
S. Pantoom, Adam Pomorski, K. Huth, C. Hund, Janine Petters, A. Krężel, A. Hermann, J. Lukas   +7 more
semanticscholar   +1 more source

Epigallocatechin-3-gallate induces autophagy-related apoptosis associated with LC3B II and Beclin expression of bladder cancer cells.

Journal of food biochemistry, 2021
The incidence of bladder cancer in traditional green tea-consuming countries was dramatically lower than low green tea-consuming countries. Epigallocatechin-3-gallate (EGCG), an active ingredient extracted from green tea, showed effective inhibition of ...
Zhaofa Yin, Juan Li, Le Kang, Xiangyang Liu, Jianguo Luo, Ling Zhang, Yuting Li, Jiarong Cai   +7 more
semanticscholar   +1 more source

Autophagy processes are dependent on EGF receptor signaling [PDF]

, 2018
Autophagy is a not well-understood conserved mechanism activated during nutritional deprivation in order to maintain cellular homeostasis. In the present study, we investigated the correlations between autophagy, apoptosis and the MAPK pathways in ...
Capodifoglio, Sabrina, Caruso, Marika, Conti, Pio, Flati, Vincenzo, Iuliis, Vincenzo De, Lanuti, Paola, Marino, Antonio, Marricareda, Valeria, Martinotti, Stefano, Marynuk, Anna, Talora, Claudio, Toniato, Elena, Ursi, Sebastiano   +12 more
core   +1 more source

LC3B Labeling on Terrestrial Isopod Adipocytes

BIO-PROTOCOL, 2013
The LC3B protein plays a critical role in autophagy. Normally, this protein resides in the cytosol, but following cleavage and lipidation with phosphatidylethanolamine, LC3B associates with the phagophore. This localization can be used as a general marker for autophagic membranes.
Christine Braquart-Varnier, Maryline Raimond, Mathieu Sicard   +2 more
openaire   +2 more sources