Results 21 to 30 of about 38,748 (248)
Prognostic Significance of LC3B and p62/SQSTM1 Expression in Gastric Adenocarcinoma [PDF]
Anticancer Research, 2019 Background/Aim: Autophagy is a cellular mechanism that recycles cellular components to maintain homeostasis. To investigate the clinical implication of autophagy in gastric cancer, the autophagy markers with autophagosome formation, LC3B and selective ...
J. Kim +8 more
semanticscholar +3 more sources
Regulation of LC3B levels by ubiquitination and proteasomal degradation [PDF]
Autophagy, 2020 Like other biological processes, macroautophagy/autophagy must be tightly controlled for maintenance of cellular homeostasis and for proper response to changing cellular conditions. To gain insights into the regulation of autophagy, we recently conducted a genome-wide CRISPR-Cas9 knockout screen using cells expressing endogenous LC3B tagged with GFP ...
Rui, Jia, Juan S, Bonifacino
openaire +2 more sources
Autophagosome immunoisolation from GFP-LC3B mouse tissue [PDF]
Autophagy, 2018 We describe a protocol for rapid and efficient enrichment of autophagosomes from various tissues of the GFP-LC3 mouse. In order to increase the number of autophagosomes, we block autophagy flux in the GFP-LC3 mouse tissue with a single intraperitoneal injection of leupeptin 4-5 h before tissue harvesting.
Jingyu, Yao +3 more
openaire +2 more sources
Virologica Sinica, 2023 Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) has been regarded as a persistent challenge for the swine farms worldwide.
Yao Yao +6 more
semanticscholar +1 more source
Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors. [PDF]
, 2020 Autophagy, particularly with BECN1, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers.
Axelrod, Joshua +14 more
core +1 more source
Total Chemical Synthesis of LC3A and LC3B Activity-Based Probes
Biomedicines, 2023 Autophagy is a conserved cellular process involved in the degradation of intercellular materials. During this process, double-membrane vesicles called autophagosomes engulf cytoplasmic components ready for degradation. A key component in the formation of autophagosomes are the autophagy-related (Atg) proteins, including microtubule-associated protein ...
Yara Huppelschoten +4 more
openaire +4 more sources
Frontiers in Pharmacology, 2022 Recent studies indicated that hepatocyte senescence plays an important role in the development of alcoholic fatty liver disease (AFLD), suggesting that inhibition of hepatocyte senescence might be a potential strategy for AFLD treatment.
Xiaoyu Qi +9 more
semanticscholar +1 more source
Cell & Bioscience, 2022 Background Age-related macular degeneration (AMD) leads to gradual central vision loss and eventual irreversible blindness. Melatonin, an endogenous hormone, exhibits anti-inflammatory and antitumor effects; however, the role it plays in AMD remains ...
Kai Wang +5 more
semanticscholar +1 more source
The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport [PDF]
, 2020 Ubiquitination regulates several biological processes, however the role of specific members of the ubiquitinome on intracellular membrane trafficking is not yet fully understood.
Arias-Muñoz, Eloisa +16 more
core +2 more sources
LC3A, LC3B and Beclin-1 Expression in Gastric Cancer [PDF]
Anticancer Research, 2018 The current study examined the key proteins involved in autophagosome formation and their prognostic role in gastric cancer.Paraffin-embedded tissues from 121 consecutive patients treated with surgery for gastric cancer were analyzed immunohistochemically for the expression of autophagic proteins microtubule-associated proteins 1A/1B light chain 3A and
Alexandra, Giatromanolaki +4 more
openaire +2 more sources