Results 11 to 20 of about 38,748 (248)

Extracts of Feijoa Inhibit Toll-Like Receptor 2 Signaling and Activate Autophagy Implicating a Role in Dietary Control of IBD [PDF]

PLoS ONE, 2015
Inflammatory bowel disease (IBD) is a heterogeneous chronic inflammatory disease affecting the gut with limited treatment success for its sufferers.
A Asea, A Scalbert, A Scalbert, AK Abbas, C Fiocchi, C Huebner, CH Seow, CN Serhan, D Del Rio, D Li, David M. Ojcius, DM Shin, DRE Ranoa, DW Hommes, FX Li, G Kroemer, Gareth Marlow, H Shapiro, H Sies, J da Silva Correia, JK Hou, L Bravo, L Frolova, L Zhao, Lynnette R Ferguson, M Fukata, M Yu, Nasef N Ahmed, Noha Ahmed Nasef, Penny Powell, PT Liu, Q Zhang, R Gonzalez, R Medzhitov, S Priego, Sunali Mehta, T Saitoh, T Sato, Tom Wileman, Y-Y Li   +39 more
core   +11 more sources

Robust LC3B lipidation analysis by precisely adjusting autophagic flux [PDF]

Scientific Reports, 2022
Autophagic flux can be quantified based on the accumulation of lipidated LC3B in the presence of late-stage autophagy inhibitors. This method has been widely applied to identify novel compounds that activate autophagy.
Martina P. Liebl, S. Meister, Lisa Frey, Kristina Hendrich, A. Klemmer, Bettina Wohlfart, Christopher Untucht, Judith Nuber, C. Pohl, V. Lakics   +9 more
semanticscholar   +4 more sources

LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes.

Current Biology, 2021
Macroautophagy (hereafter referred to as autophagy) is a conserved process that promotes cellular homeostasis through the degradation of cytosolic components, also known as cargo.
Jose L. Nieto-Torres, Sean-Luc Shanahan, Romain Chassefeyre, Tai Chaiamarit, S. Zaretski, Sara Landeras-Bueno, A. Verhelle, S. Encalada, Malene Hansen   +8 more
semanticscholar   +3 more sources

Tepsin binds LC3B to promote ATG9A trafficking and delivery

Molecular Biology of the Cell
Tepsin is an established accessory protein found in Adaptor Protein 4 (AP-4) coated vesicles, but the biological role of tepsin remains unknown. AP-4 vesicles originate at the trans-Golgi network (TGN) and target the delivery of ATG9A, a scramblase ...
Natalie S. Wallace, John E. Gadbery, Cameron I. Cohen, Amy K. Kendall, L. Jackson   +4 more
semanticscholar   +3 more sources

Stapled Peptide Inhibitors of Autophagy Adapter LC3B [PDF]

ChemBioChem, 2020
A growing body of evidence suggests that autophagy inhibition enhances the effectiveness of chemotherapy, especially in difficult‐to‐treat cancers. Existing autophagy inhibitors are primarily lysosomotropic agents.
Robert A. Cerulli, Livia Shehaj, H. Brown, J. Pace, Y. Mei, Joshua A. Kritzer   +5 more
semanticscholar   +4 more sources

LC3B globular structures correlate with survival in esophageal adenocarcinoma [PDF]

BMC Cancer, 2015
Background: Esophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %.
Abdallah, Ayat R., Cathcart, Mary-Clare, El-Mashad, Shereen M., Kay, Elaine W., McKenna, Sharon L., O'Donovan, Tracey R., O'Grady, Anthony, O'Reilly, Seamus, O'Sullivan, Gerald C., O'Sullivan, Jacintha, Reynolds, John   +10 more
core   +8 more sources

The role of LC3B in autophagy as an RNA-binding protein

Autophagy, 2022
The hallmark of cellular events observed upon macroautophagic/autophagic induction is the conjugation of LC3B, one of the mammalian Atg8 homologs, with phosphatidylethanolamine.
H. Hwang, Yoon Ki Kim
semanticscholar   +3 more sources

CAV1-CAVIN1-LC3B-mediated autophagy regulates high glucose-stimulated LDL transcytosis [PDF]

Autophagy, 2020
Diabetes is a recognized high-risk factor for the development of atherosclerosis, in which macroautophagy/autophagy is emerging to play essential roles.
X. Bai, Xiao-Yan Yang, Xiong Jia, Yueguang Rong, Lulu Chen, T. Zeng, X. Deng, Wenjing Li, Guangjie Wu, Ling Wang, Ye Li, Jing Zhang, Z. Xiong, L. Xiong, Yumei Wang, Lin Zhu, Ying Zhao, Si Jin   +17 more
semanticscholar   +3 more sources

Prognostic Value of LC3B and p62 Expression in Small Intestinal Adenocarcinoma [PDF]

Journal of Clinical Medicine, 2021
Autophagy, a mechanism that maintains cellular homeostasis, is involved in tumor cell growth and survival in cancer, and autophagy inhibitors have been tested clinical trials for anticancer therapy.
Jeong-Won Kim, S. Jun, J. Kim, Y. Oh, Ghilsuk Yoon, Seung‐Mo Hong, J. Chung   +6 more
semanticscholar   +3 more sources

LC3B phosphorylation: autophagosome’s ticket for a ride toward the cell nucleus

Autophagy, 2021
Macroautophagy/autophagy is a multi-step process that leads to cargo degradation via the fusion of hydrolases-containing lysosomes with cargo-loaded autophagosomes.
Jose L. Nieto-Torres, S. Encalada, M. Hansen   +2 more
semanticscholar   +3 more sources