Results 41 to 50 of about 68,926 (299)
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy [PDF]
Autophagy, 2010 Accumulation of ubiquitinated proteins in cytoplasmic and/or nuclear inclusions is a hallmark of several diseases associated with premature cell death. SQSTM1/p62 is known to bind ubiquitinated substrates and aid their aggregation and degradation by macroautophagy.
Terje Høyvarde, Clausen +10 more
openaire +2 more sources
p62-, ubiquitin-, and ubiquilin-2-positive inclusions.
, 2017 p62, ubiquitin, and ubiquilin-2 are involved in protein degradation pathways. A, B) p62-positive inclusions. C, D) ubiquitin- or ubiquilin-2 positive inclusions on adjacent sections (thin paraffin sections).
Wen-Lang Lin (530295) +8 more
core +1 more source
, 2018 Artemisinins have been reported to have diverse functions, such as antimalaria, anticancer, anti-inflammation, and immunoregulation activities. DC32 [(9α,12α-dihydroartemisinyl) bis(2′-chlorocinnmate)], a dihydroartemisinin derivative possessing potent ...
Chunhua Yao (2471311) +5 more
core +1 more source
Targeting YAP‐p62 signaling axis suppresses the EGFR‐TKI‐resistant lung adenocarcinoma
Cancer Medicine, 2021 Background Despite the progress of advanced target therapeutic agents and immune checkpoint inhibitors, EGFR‐TKI resistance is still one of the biggest obstacles in treating lung cancer. Clinical studies with autophagy inhibitors are actively underway to
Hee Sun Park +14 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
p62 at the Crossroads of Autophagy, Apoptosis, and Cancer [PDF]
Cell, 2009 The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-kappaB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that
Moscat, Jorge, Diaz-Meco, Maria T.
openaire +2 more sources
, 2019 A. Endogenous ROS production in viral latency was measured by flow cytometry with the CellRox Green reagent (Invitrogen). Three independent repeats were conducted, and representative results are shown.
Ayrianna Sparks-Wallace (6631682) +9 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Selective Autophagy and Xenophagy in Infection and Disease
Frontiers in Cell and Developmental Biology, 2018 Autophagy, a cellular homeostatic process, which ensures cellular survival under various stress conditions, has catapulted to the forefront of innate defense mechanisms during intracellular infections.
Vartika Sharma +4 more
doaj +1 more source
The macroenviromental control of cancer metabolism by p62 [PDF]
Cell Cycle, 2018 Metabolic reprogramming is a hallmark of cancer, but most studies focus on the molecular alterations in cancer cells and much less is known on the role of cancer metabolism, from a holistic perspective, for tumor initiation and progression. Increasing epidemiological evidence highlights the tremendous impact that cancer progression has on the host ...
Jianfeng, Huang +2 more
openaire +2 more sources