Results 41 to 50 of about 63,564 (302)

Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis

Military Medical Research, 2022
Background Cerebral ischemia-reperfusion injury (CIRI) refers to a secondary brain injury that can occur when the blood supply to the ischemic brain tissue is restored. However, the mechanism underlying such injury remains elusive.
Xue Zeng, Yun-Dong Zhang, Rui-Yan Ma, Yuan-Jing Chen, Xin-Ming Xiang, Dong-Yao Hou, Xue-Han Li, He Huang, Tao Li, Chen-Yang Duan   +9 more
doaj   +1 more source

Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas. [PDF]

, 2016
Esophageal adenocarcinomas (EAC) are aggressive tumors with considerable rates of chemoresistance. Autophagy is a lysosome-dependent degradation process, characterized by the formation of vesicles called autophagosomes, and has been implicated in cancer.
Seiler, Christian A., Tschan, Mario, Kröll, Dino, Schläfli, Anna, Dislich, Bastian, Berezowska, Sabina Anna, Langer, Rupert, Adams, Olivia Joan   +7 more
core   +1 more source

The Binding of PD-L1 and Akt Facilitates Glioma Cell Invasion Upon Starvation via Akt/Autophagy/F-Actin Signaling

Frontiers in Oncology, 2019
Glioma, especially glioblastoma, is pathologically characterized by high aggressiveness, which largely contributed to the ineffectiveness of current therapies.
Ruo Qiao Chen, Xiao Hong Xu, Feng Liu, Chun Yang Li, Yuan Jun Li, Xiang Rui Li, Guo Yong Jiang, Feng Hu, Di Liu, Feng Pan, Xin Yao Qiu, Xiao Qian Chen   +11 more
doaj   +1 more source

RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems

Redox Biology, 2017
Reactivation of p53 and induction of tumor cell apoptosis (RITA) is a small molecule that blocks p53–MDM2 interaction, thereby reactivating p53 in tumors.
Daiha Shin, Eun Hye Kim, Jaewang Lee, Jong-Lyel Roh   +3 more
doaj   +1 more source

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy [PDF]

Autophagy, 2010
Accumulation of ubiquitinated proteins in cytoplasmic and/or nuclear inclusions is a hallmark of several diseases associated with premature cell death. SQSTM1/p62 is known to bind ubiquitinated substrates and aid their aggregation and degradation by macroautophagy.
Terje Høyvarde, Clausen, Trond, Lamark, Pauline, Isakson, Kim, Finley, Kenneth Bowitz, Larsen, Andreas, Brech, Aud, Øvervatn, Harald, Stenmark, Geir, Bjørkøy, Anne, Simonsen, Terje, Johansen   +10 more
openaire   +2 more sources

Comparative Gene Expression Analysis in WM164 Melanoma Cells Revealed That β-β-Dimethylacrylshikonin Leads to ROS Generation, Loss of Mitochondrial Membrane Potential, and Autophagy Induction

Molecules, 2018
Skin cancer is currently diagnosed as one in every three cancers. Melanoma, the most aggressive form of skin cancer, is responsible for 79% of skin cancer deaths and the incidence is rising faster than in any other solid tumor type.
Nadine Kretschmer, Alexander Deutsch, Christin Durchschein, Beate Rinner, Alexander Stallinger, Juan Carlos Higareda-Almaraz, Marcel Scheideler, Birgit Lohberger, Rudolf Bauer   +8 more
doaj   +1 more source

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

Neurobiology of Disease, 2015
Huntington Disease (HD) is a progressive neurodegenerative disease caused by an elongated CAG repeat in the huntingtin (HTT) gene that encodes a polyglutamine tract in the HTT protein.
Bibiana K.Y. Wong, Dagmar E. Ehrnhoefer, Rona K. Graham, Dale D.O. Martin, Safia Ladha, Valeria Uribe, Lisa M. Stanek, Sonia Franciosi, Xiaofan Qiu, Yu Deng, Vlad Kovalik, Weining Zhang, Mahmoud A. Pouladi, Lamya S. Shihabuddin, Michael R. Hayden   +14 more
doaj   +1 more source

p62-, ubiquitin-, and ubiquilin-2-positive inclusions.

, 2017
p62, ubiquitin, and ubiquilin-2 are involved in protein degradation pathways. A, B) p62-positive inclusions. C, D) ubiquitin- or ubiquilin-2 positive inclusions on adjacent sections (thin paraffin sections).
Wen-Lang Lin (530295), Sumitra Miriyala (353955), Kevin J. McCarthy (3633019), Ronald L. Klein (307267), Manikandan Panchatcharam (3633031), Kasey L. Jackson (3633022), Dennis W. Dickson (21100), Robert D. Dayton (3633025), Monica Castanedes-Casey (3633028)   +8 more
core   +1 more source

Autophagy Promotes Duck Tembusu Virus Replication by Suppressing p62/SQSTM1-Mediated Innate Immune Responses In Vitro

Vaccines, 2020
Duck Tembusu virus (DTMUV) has recently appeared in ducks in China and the key cellular determiners for DTMUV replication in host cells remain unknown.
Zhiqiang Hu, Yuhong Pan, Anchun Cheng, Xingcui Zhang, Mingshu Wang, Shun Chen, Dekang Zhu, Mafeng Liu, Qiao Yang, Ying Wu, Xinxin Zhao, Juan Huang, Shaqiu Zhang, Sai Mao, Xumin Ou, Yanling Yu, Ling Zhang, Yunya Liu, Bin Tian, Leichang Pan, Mujeeb Ur Rehman, Zhongqiong Yin, Renyong Jia   +22 more
doaj   +1 more source

Nonstructural proteins 2B and 4A of Tembusu virus induce complete autophagy to promote viral multiplication in vitro

Veterinary Research, 2023
Tembusu virus (TMUV) is an emerging flavivirus that has broken out in different regions of China. TMUV infection has been reported to induce autophagy in duck embryo fibroblast cells.
Wangyang Tan, Senzhao Zhang, Yu He, Zhen Wu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Di Sun, Bin Tian, Shun Chen, Anchun Cheng   +19 more
doaj   +1 more source