Results 21 to 30 of about 63,564 (302)

p62 Promotes Malignancy of Hepatocellular Carcinoma by Regulating the Secretion of Exosomes and the Localization of β-Catenin

Frontiers in Bioscience-Landmark, 2022
Background: p62 is a multi-domain protein and participates in a variety of cellular biological activities. p62 is also related to tumor malignancy. However, the underlying molecular mechanism of p62 regulating the progression of hepatocellular carcinoma (
Weibang Yang, Jinxing Wei, Lihong Lv, Jiyan Xie, Ang Li, Zhihua Zheng, Wenfeng Zhuo, Peiqing Liu, Jun Min   +8 more
doaj   +1 more source

Prevention of non‐alcoholic steatohepatitis by long‐term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice

Physiological Reports, 2021
Exercise ameliorates nonalcoholic fatty liver disease (NAFLD) by inducing phenotypic changes in Kupffer cells (KCs). p62/Sqstm1‐knockout (p62‐KO) mice develop NAFLD alongside hyperphagia‐induced obesity. We evaluated (1) the effects of long‐term exercise
Ikuru Miura, Shoichi Komine, Kosuke Okada, Shota Wada, Eiji Warabi, Fumihiko Uchida, Sechang Oh, Hideo Suzuki, Yuji Mizokami, Junichi Shoda   +9 more
doaj   +1 more source

Measurement of Autophagy Activity Reveals Time-Dependent, Bacteria-Specific Turnover during Mycobacterium tuberculosis Infection

Pathogens, 2022
The intracellular pathogen, Mycobacterium tuberculosis (M. tb) uses various mechanisms to evade its killing. One of such is phagosomal damage and cytosolic translocation which is then targeted by the host’s bactericidal autophagy pathway. It is suggested
Naomi Okugbeni, André du Toit, Victoria Cole-Holman, Glynis Johnson, Ben Loos, Craig Kinnear   +5 more
doaj   +1 more source

Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis

Cell Death and Disease, 2021
p62/SQSTM1 is frequently up-regulated in many cancers including hepatocellular carcinoma. Highly expressed p62 promotes hepato-carcinogenesis by activating many signaling pathways including Nrf2, mTORC1, and NFκB signaling.
Lifeng Feng, Miaoqin Chen, Yiling Li, Muchun Li, Shiman Hu, Bingluo Zhou, Liyuan Zhu, Lei Yu, Qiyin Zhou, Linghui Tan, Huimin An, Xian Wang, Hongchuan Jin   +12 more
doaj   +1 more source

Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy

Cell & Bioscience, 2023
Background Macro-autophagy/Autophagy is an evolutionarily well-conserved recycling process to maintain the balance through precise spatiotemporal regulation.
Qin Xia, Yang Li, Wanting Xu, Chengwei Wu, Hanfei Zheng, Liqun Liu, Lei Dong   +6 more
doaj   +1 more source

The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer

Biomedicines, 2021
p62 is a highly conserved, multi-domain, and multi-functional adaptor protein critically involved in several important cellular processes. Via its pronounced domain architecture, p62 binds to numerous interaction partners, thereby influencing key ...
Paulina Hennig, Gabriele Fenini, Michela Di Filippo, Tugay Karakaya, Hans-Dietmar Beer   +4 more
doaj   +1 more source

p62 is Negatively Implicated in the TRAF6-BECN1 Signaling Axis for Autophagy Activation and Cancer Progression by Toll-Like Receptor 4 (TLR4)

Cells, 2020
Toll-like receptors (TLRs) induce the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and autophagy through the TNF (Tumor necrosis factor) receptor-associated factor 6 (TRAF6)-evolutionarily conserved signaling ...
Mi-Jeong Kim, Yoon Min, Ji Seon Im, Juhee Son, Joo Sang Lee, Ki-Young Lee   +5 more
doaj   +1 more source

Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62‐dependent manner

FEBS Open Bio, 2022
Homologous to E6AP C‐terminus (HECT)‐type E3 ubiquitin ligase SMAD‐specific E3 ubiquitin protein ligase 1 (Smurf1) was originally identified to ubiquitinate Smad protein in the TGF‐β/BMP signaling pathway.
Da Han, Shengzhen Li, Qin Xia, Xinyi Meng, Lei Dong   +4 more
doaj   +1 more source

Emodin Ameliorates the Efficacy of Carfilzomib in Multiple Myeloma Cells via Apoptosis and Autophagy

Biomedicines, 2022
Background: Carfilzomib, the proteasome inhibitor, can increase the overall survival rate of multiple myeloma (MM) patients undergoing targeted therapy.
Chin-Mu Hsu, Chia-Hung Yen, Shu-Chen Wang, Yi-Chang Liu, Chien-Tzu Huang, Min-Hong Wang, Tzer-Ming Chuang, Ya-Lun Ke, Tsung-Jang Yeh, Yuh-Ching Gau, Jeng-Shiun Du, Hui-Ching Wang, Shih-Feng Cho, Yuhsin Tsai, Chi-En Hsiao, Samuel Yien Hsiao, Hui-Hua Hsiao   +16 more
doaj   +1 more source

E1-Like Activating Enzyme Atg7 Is Preferentially Sequestered into p62 Aggregates via Its Interaction with LC3-I [PDF]

, 2013
p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified.
Wang, W, Chen, Z, Gao Wentao, Wang, Wei, Gao, Wentao, Zhixia Chen, Wentao Gao, Wang Wei, Stang Michael T., Michael T Stang, Chen, Zhixia, Michael T. Stang, Gao, W, Wei Wang, Stang, MT, Stang, Michael T., Zhu, Wei-Guo, Chen Zhixia   +17 more
core   +1 more source