Results 21 to 30 of about 54,852 (260)

Regulation of autophagy by AMP-activated protein kinase/ sirtuin 1 pathway reduces spinal cord neurons damage [PDF]

Iranian Journal of Basic Medical Sciences, 2017
Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after
Peng Yan, Liangjie Bai, Wei Lu, Yuzhong Gao, Yunlong Bi, Gang Lv   +5 more
doaj   +1 more source

Expression Pattern of p62 in Primary Age-Related Tauopathy: Staging of p62 in PART

Frontiers in Aging Neuroscience, 2022
The present study analyzed the distribution pattern of p62 immunoreactivity in brains of primary age-related tauopathy (PART) and Braak NFT matched pre-AD and Alzheimer’s disease (AD) patients using immunohistochemistry in combination with semi-quantitative evaluation.
Xin Wang, Xin Wang, Lei Zhang, Lei Zhang, Hui Lu, Juanli Wu, Huazheng Liang, Bing Sun, Keqing Zhu, Keqing Zhu   +9 more
openaire   +3 more sources

How multi-component cascades operate in cells: lessons from the ubiquitin system-containing liquid-separated condensates

Molecular & Cellular Oncology, 2021
Membraneless condensates have recently caught the attention of biologists as hubs for cellular components required for catalysis of basic processes.
Afu Fu, Ido Livneh, Aaron Ciechanover, Victoria Cohen-Kaplan   +3 more
doaj   +1 more source

Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry

European Journal of Histochemistry, 2015
Autophagy assures cellular homeostasis, and gains increasing importance in cancer, where it impacts on carcinogenesis, propagation of the malignant phenotype and development of resistance.
A.M. Schläfli, S. Berezowska, O. Adams, R. Langer, M.P. Tschan   +4 more
doaj   +1 more source

The Binding of PD-L1 and Akt Facilitates Glioma Cell Invasion Upon Starvation via Akt/Autophagy/F-Actin Signaling

Frontiers in Oncology, 2019
Glioma, especially glioblastoma, is pathologically characterized by high aggressiveness, which largely contributed to the ineffectiveness of current therapies.
Ruo Qiao Chen, Xiao Hong Xu, Feng Liu, Chun Yang Li, Yuan Jun Li, Xiang Rui Li, Guo Yong Jiang, Feng Hu, Di Liu, Feng Pan, Xin Yao Qiu, Xiao Qian Chen   +11 more
doaj   +1 more source

RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems

Redox Biology, 2017
Reactivation of p53 and induction of tumor cell apoptosis (RITA) is a small molecule that blocks p53–MDM2 interaction, thereby reactivating p53 in tumors.
Daiha Shin, Eun Hye Kim, Jaewang Lee, Jong-Lyel Roh   +3 more
doaj   +1 more source

Comparative Gene Expression Analysis in WM164 Melanoma Cells Revealed That β-β-Dimethylacrylshikonin Leads to ROS Generation, Loss of Mitochondrial Membrane Potential, and Autophagy Induction

Molecules, 2018
Skin cancer is currently diagnosed as one in every three cancers. Melanoma, the most aggressive form of skin cancer, is responsible for 79% of skin cancer deaths and the incidence is rising faster than in any other solid tumor type.
Nadine Kretschmer, Alexander Deutsch, Christin Durchschein, Beate Rinner, Alexander Stallinger, Juan Carlos Higareda-Almaraz, Marcel Scheideler, Birgit Lohberger, Rudolf Bauer   +8 more
doaj   +1 more source

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

Neurobiology of Disease, 2015
Huntington Disease (HD) is a progressive neurodegenerative disease caused by an elongated CAG repeat in the huntingtin (HTT) gene that encodes a polyglutamine tract in the HTT protein.
Bibiana K.Y. Wong, Dagmar E. Ehrnhoefer, Rona K. Graham, Dale D.O. Martin, Safia Ladha, Valeria Uribe, Lisa M. Stanek, Sonia Franciosi, Xiaofan Qiu, Yu Deng, Vlad Kovalik, Weining Zhang, Mahmoud A. Pouladi, Lamya S. Shihabuddin, Michael R. Hayden   +14 more
doaj   +1 more source

Autophagy Promotes Duck Tembusu Virus Replication by Suppressing p62/SQSTM1-Mediated Innate Immune Responses In Vitro

Vaccines, 2020
Duck Tembusu virus (DTMUV) has recently appeared in ducks in China and the key cellular determiners for DTMUV replication in host cells remain unknown.
Zhiqiang Hu, Yuhong Pan, Anchun Cheng, Xingcui Zhang, Mingshu Wang, Shun Chen, Dekang Zhu, Mafeng Liu, Qiao Yang, Ying Wu, Xinxin Zhao, Juan Huang, Shaqiu Zhang, Sai Mao, Xumin Ou, Yanling Yu, Ling Zhang, Yunya Liu, Bin Tian, Leichang Pan, Mujeeb Ur Rehman, Zhongqiong Yin, Renyong Jia   +22 more
doaj   +1 more source

Nonstructural proteins 2B and 4A of Tembusu virus induce complete autophagy to promote viral multiplication in vitro

Veterinary Research, 2023
Tembusu virus (TMUV) is an emerging flavivirus that has broken out in different regions of China. TMUV infection has been reported to induce autophagy in duck embryo fibroblast cells.
Wangyang Tan, Senzhao Zhang, Yu He, Zhen Wu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Di Sun, Bin Tian, Shun Chen, Anchun Cheng   +19 more
doaj   +1 more source