Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry [PDF]
European Journal of Histochemistry, 2015 Autophagy assures cellular homeostasis, and gains increasing importance in cancer, where it impacts on carcinogenesis, propagation of the malignant phenotype and development of resistance.
A.M. Schläfli +4 more
doaj +3 more sources
Mechanism and structural requirements for formation of p62 bodies and degradation of p62 by selective autophagy [PDF]
, 2021 Selective autophagy is responsible for the lysosomal degradation of damaged and surplus cytoplasmic components, including misfolded proteins and dysfunctional organelles. Selective autophagy is required for protein and organelle quality control basally and upon stress.
Palara, Anthimi
openaire +2 more sources
P62: An emerging oncotarget for osteolytic metastasis [PDF]
Journal of Bone Oncology, 2016 Bone metastasis occurs in the majority of late-stage tumors with poor prognosis. It is mainly classified as osteoblastic metastasis and osteolytic metastasis. The pathogenesis of osteolytic metastasis is a "vicious cycle" between tumor cells and bone cells (primarily the osteoclasts), which is mediated by secretory factors. The P62 adapter protein is a
Jing Zhang, Zuozhang Yang, Jian Dong
openaire +4 more sources
Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis
Cell Death and Disease, 2021 p62/SQSTM1 is frequently up-regulated in many cancers including hepatocellular carcinoma. Highly expressed p62 promotes hepato-carcinogenesis by activating many signaling pathways including Nrf2, mTORC1, and NFκB signaling.
Lifeng Feng +12 more
doaj +1 more source
Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy
Cell & Bioscience, 2023 Background Macro-autophagy/Autophagy is an evolutionarily well-conserved recycling process to maintain the balance through precise spatiotemporal regulation.
Qin Xia +6 more
doaj +1 more source
The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer
Biomedicines, 2021 p62 is a highly conserved, multi-domain, and multi-functional adaptor protein critically involved in several important cellular processes. Via its pronounced domain architecture, p62 binds to numerous interaction partners, thereby influencing key ...
Paulina Hennig +4 more
doaj +1 more source
Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62‐dependent manner
FEBS Open Bio, 2022 Homologous to E6AP C‐terminus (HECT)‐type E3 ubiquitin ligase SMAD‐specific E3 ubiquitin protein ligase 1 (Smurf1) was originally identified to ubiquitinate Smad protein in the TGF‐β/BMP signaling pathway.
Da Han +4 more
doaj +1 more source
The caspase-6–p62 axis modulates p62 droplets based autophagy in a dominant-negative manner [PDF]
, 2021 SQSTM1/p62, as a major autophagy receptor, forms droplets that are critical for cargo recognition, nucleation, and clearance. p62 droplets also function as liquid assembly platforms to allow the formation of autophagosomes at their surfaces.
Luo, Shouqing +7 more
core +1 more source
Emodin Ameliorates the Efficacy of Carfilzomib in Multiple Myeloma Cells via Apoptosis and Autophagy
Biomedicines, 2022 Background: Carfilzomib, the proteasome inhibitor, can increase the overall survival rate of multiple myeloma (MM) patients undergoing targeted therapy.
Chin-Mu Hsu +16 more
doaj +1 more source
E1-Like Activating Enzyme Atg7 Is Preferentially Sequestered into p62 Aggregates via Its Interaction with LC3-I [PDF]
, 2013 p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified.
Wang, W +17 more
core +2 more sources