S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy
Molecular Cell, 2023 p62 is a well-characterized autophagy receptor that recognizes and sequesters specific cargoes into autophagosomes for degradation. p62 promotes the assembly and removal of ubiquitinated proteins by forming p62-liquid droplets. However, it remains unclear how autophagosomes efficiently sequester p62 droplets.
Aimin Yang
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p62-Nrf2-p62 Mitophagy Regulatory Loop as a Target for Preventive Therapy of Neurodegenerative Diseases [PDF]
Brain Sciences, 2020 Turnover of the mitochondrial pool due to coordinated processes of mitochondrial biogenesis and mitophagy is an important process in maintaining mitochondrial stability. An important role in this process is played by the Nrf2/ARE signaling pathway, which
Artem P. Gureev +4 more
doaj +4 more sources
Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination
Cell Reports, 2017 p62/SQSTM1 (p62) is a scaffolding protein that facilitates the formation and degradation of ubiquitinated aggregates via its self-interaction and ubiquitin binding domains.
Youjin Lee +2 more
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The caspase-6–p62 axis modulates p62 droplets based autophagy in a dominant-negative manner [PDF]
Cell Death & Differentiation, 2021 AbstractSQSTM1/p62, as a major autophagy receptor, forms droplets that are critical for cargo recognition, nucleation, and clearance. p62 droplets also function as liquid assembly platforms to allow the formation of autophagosomes at their surfaces.
Evelina Valionyte +7 more
openaire +4 more sources
Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry [PDF]
European Journal of Histochemistry, 2015 Autophagy assures cellular homeostasis, and gains increasing importance in cancer, where it impacts on carcinogenesis, propagation of the malignant phenotype and development of resistance.
A.M. Schläfli +4 more
doaj +2 more sources
p62: a versatile multitasker takes on cancer [PDF]
Trends in Biochemical Sciences, 2012 Since its initial discovery as an atypical protein kinase C (PKC)-interacting protein, p62 has emerged as a crucial molecule in a myriad of cellular functions. This multifunctional role of p62 is explained by its ability to interact with several key components of various signaling mechanisms.
Jorge Moscat, Maria T Diaz-Meco
exaly +3 more sources
Beyond cargo clearance: p62 coordinates cAMP signalling and autophagy to drive cell fate decisions in Dictyostelium discoideum [PDF]
Autophagy Reportsp62 is a multi-domain selective autophagy receptor and signaling scaffold conserved across eukaryotes. However, its evolutionary roots and functional significance in early-diverging eukaryotes like Dictyostelium have remained unexplored.
Saksham Gautam, Shweta Saran
doaj +2 more sources
Mechanism and structural requirements for formation of p62 bodies and degradation of p62 by selective autophagy [PDF]
, 2021 Selective autophagy is responsible for the lysosomal degradation of damaged and surplus cytoplasmic components, including misfolded proteins and dysfunctional organelles. Selective autophagy is required for protein and organelle quality control basally and upon stress.
Palara, Anthimi
openaire +2 more sources
Frontiers in Physiology, 2022 Introduction: Obesity is a risk factor for many diseases because it leads to a reduction in skeletal muscle mass and promotes insulin resistance. p62/Sqstm1-knockout mice are a model of metabolic syndrome; show obesity, insulin resistance, and non ...
Ikuru Miura +8 more
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‘High vault-age’: non-coding RNA control of autophagy [PDF]
Open Biology, 2020 RNA-binding proteins typically change the fate of RNA, such as stability, translation or processing. Conversely, we recently uncovered that the small non-coding vault RNA 1-1 (vtRNA1-1) directly binds to the autophagic receptor p62/SQSTM1 and changes the
Magdalena Büscher +2 more
doaj +1 more source