Results 11 to 20 of about 54,852 (260)

Measurement of Autophagy Activity Reveals Time-Dependent, Bacteria-Specific Turnover during Mycobacterium tuberculosis Infection

Pathogens, 2022
The intracellular pathogen, Mycobacterium tuberculosis (M. tb) uses various mechanisms to evade its killing. One of such is phagosomal damage and cytosolic translocation which is then targeted by the host’s bactericidal autophagy pathway. It is suggested
Naomi Okugbeni, André du Toit, Victoria Cole-Holman, Glynis Johnson, Ben Loos, Craig Kinnear   +5 more
doaj   +1 more source

Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy

Cell & Bioscience, 2023
Background Macro-autophagy/Autophagy is an evolutionarily well-conserved recycling process to maintain the balance through precise spatiotemporal regulation.
Qin Xia, Yang Li, Wanting Xu, Chengwei Wu, Hanfei Zheng, Liqun Liu, Lei Dong   +6 more
doaj   +1 more source

The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer

Biomedicines, 2021
p62 is a highly conserved, multi-domain, and multi-functional adaptor protein critically involved in several important cellular processes. Via its pronounced domain architecture, p62 binds to numerous interaction partners, thereby influencing key ...
Paulina Hennig, Gabriele Fenini, Michela Di Filippo, Tugay Karakaya, Hans-Dietmar Beer   +4 more
doaj   +1 more source

p62 is Negatively Implicated in the TRAF6-BECN1 Signaling Axis for Autophagy Activation and Cancer Progression by Toll-Like Receptor 4 (TLR4)

Cells, 2020
Toll-like receptors (TLRs) induce the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and autophagy through the TNF (Tumor necrosis factor) receptor-associated factor 6 (TRAF6)-evolutionarily conserved signaling ...
Mi-Jeong Kim, Yoon Min, Ji Seon Im, Juhee Son, Joo Sang Lee, Ki-Young Lee   +5 more
doaj   +1 more source

Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination

Cell Reports, 2017
p62/SQSTM1 (p62) is a scaffolding protein that facilitates the formation and degradation of ubiquitinated aggregates via its self-interaction and ubiquitin binding domains.
YouJin Lee, Tsui-Fen Chou, Sara K. Pittman, Amy L. Keith, Babak Razani, Conrad C. Weihl   +5 more
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Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62‐dependent manner

FEBS Open Bio, 2022
Homologous to E6AP C‐terminus (HECT)‐type E3 ubiquitin ligase SMAD‐specific E3 ubiquitin protein ligase 1 (Smurf1) was originally identified to ubiquitinate Smad protein in the TGF‐β/BMP signaling pathway.
Da Han, Shengzhen Li, Qin Xia, Xinyi Meng, Lei Dong   +4 more
doaj   +1 more source

p62 acts as an oncogene and is targeted by miR-124-3p in glioma

Cancer Cell International, 2019
Background Glioma is the most common central nervous system (CNS) tumour. p62, an important autophagy adaptor, plays a crucial role in cancer. However, the role of p62 in the progression of glioma is poorly characterized.
Danni Deng, Kaiming Luo, Hongmei Liu, Xichen Nie, Lian Xue, Rong Wang, Yuan Xu, Jun Cui, Naiyuan Shao, Feng Zhi   +9 more
doaj   +1 more source

Emodin Ameliorates the Efficacy of Carfilzomib in Multiple Myeloma Cells via Apoptosis and Autophagy

Biomedicines, 2022
Background: Carfilzomib, the proteasome inhibitor, can increase the overall survival rate of multiple myeloma (MM) patients undergoing targeted therapy.
Chin-Mu Hsu, Chia-Hung Yen, Shu-Chen Wang, Yi-Chang Liu, Chien-Tzu Huang, Min-Hong Wang, Tzer-Ming Chuang, Ya-Lun Ke, Tsung-Jang Yeh, Yuh-Ching Gau, Jeng-Shiun Du, Hui-Ching Wang, Shih-Feng Cho, Yuhsin Tsai, Chi-En Hsiao, Samuel Yien Hsiao, Hui-Hua Hsiao   +16 more
doaj   +1 more source

The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant PathwaySummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background and Aims: TRIM21 is a ubiquitin E3 ligase that is implicated in numerous biological processes including immune response, cell metabolism, redox homeostasis, and cancer development.
Fang Wang, Ye Zhang, Jianliang Shen, Bin Yang, Weiwei Dai, Junrong Yan, Sara Maimouni, Heineken Q. Daguplo, Sara Coppola, Yingtang Gao, Yijun Wang, Zhi Du, Kesong Peng, Hui Liu, Qin Zhang, Fei Tang, Peng Wang, Shenglan Gao, Yongbo Wang, Wen-Xing Ding, Grace Guo, Fengmei Wang, Wei-Xing Zong   +22 more
doaj   +1 more source

Autophagy and p62 in Cardiac Proteinopathy [PDF]

Circulation Research, 2011
Rationale: Recent studies suggest an important role of autophagy in protection against αB-crystallin-based (CryAB R120G ) desmin-related cardiomyopathies (DRC), but this has not been demonstrated in a different model of cardiac proteinopathy.
Qingwen, Zheng, Huabo, Su, Mark J, Ranek, Xuejun, Wang   +3 more
openaire   +2 more sources