p62-Nrf2-p62 Mitophagy Regulatory Loop as a Target for Preventive Therapy of Neurodegenerative Diseases [PDF]
Brain Sciences, 2020 Turnover of the mitochondrial pool due to coordinated processes of mitochondrial biogenesis and mitophagy is an important process in maintaining mitochondrial stability. An important role in this process is played by the Nrf2/ARE signaling pathway, which
Artem P. Gureev +4 more
doaj +3 more sources
A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. [PDF]
, 2015 Serous Ovarian Cancers (SOC) are frequently resistant to programmed cell death. However, here we describe that these programmed death-resistant cells are nonetheless sensitive to agents that modulate autophagy.
Bartakova, Alena +10 more
core +8 more sources
Tissue specific induction of p62/sqstm1 by farnesoid X receptor [PDF]
, 2012 Background: Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily and is a ligand-activated transcription factor essential for maintaining liver and intestinal homeostasis. FXR is protective against carcinogenesis and inflammation in
Ann M. Thomas +9 more
core +7 more sources
Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62‐dependent manner
FEBS Open Bio, 2022 Homologous to E6AP C‐terminus (HECT)‐type E3 ubiquitin ligase SMAD‐specific E3 ubiquitin protein ligase 1 (Smurf1) was originally identified to ubiquitinate Smad protein in the TGF‐β/BMP signaling pathway.
Da Han +4 more
doaj +1 more source
The caspase-6–p62 axis modulates p62 droplets based autophagy in a dominant-negative manner [PDF]
Cell Death & Differentiation, 2021 AbstractSQSTM1/p62, as a major autophagy receptor, forms droplets that are critical for cargo recognition, nucleation, and clearance. p62 droplets also function as liquid assembly platforms to allow the formation of autophagosomes at their surfaces.
Evelina Valionyte +7 more
openaire +2 more sources
Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination
Cell Reports, 2017 p62/SQSTM1 (p62) is a scaffolding protein that facilitates the formation and degradation of ubiquitinated aggregates via its self-interaction and ubiquitin binding domains.
YouJin Lee +5 more
doaj +1 more source
Emodin Ameliorates the Efficacy of Carfilzomib in Multiple Myeloma Cells via Apoptosis and Autophagy
Biomedicines, 2022 Background: Carfilzomib, the proteasome inhibitor, can increase the overall survival rate of multiple myeloma (MM) patients undergoing targeted therapy.
Chin-Mu Hsu +16 more
doaj +1 more source
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates [PDF]
, 2019 The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear.
Abert, Christine +9 more
core +1 more source
p62 acts as an oncogene and is targeted by miR-124-3p in glioma
Cancer Cell International, 2019 Background Glioma is the most common central nervous system (CNS) tumour. p62, an important autophagy adaptor, plays a crucial role in cancer. However, the role of p62 in the progression of glioma is poorly characterized.
Danni Deng +9 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background and Aims: TRIM21 is a ubiquitin E3 ligase that is implicated in numerous biological processes including immune response, cell metabolism, redox homeostasis, and cancer development.
Fang Wang +22 more
doaj +1 more source