Results 71 to 80 of about 45,202 (305)
Advanced Science, EarlyView.A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen +13 more
wiley +1 more source
Effect of Low-Level Laser Therapy on the Nrf2/Keap1 Pathway in NMRI Mice with Testicular Torsion [PDF]
Journal of Mazandaran University of Medical SciencesBackground and purpose: Testicular torsion (TT) is a urological emergency characterized by twisting of the spermatic cord, which reduces blood flow and leads to testicular ischemia.
Mohammad Bayat +4 more
doaj
The Keap1 signaling in the regulation of HSP90 pathway
Cell Stress and Chaperones, 2022 The Keap1 protein is the master modulator of Nrf2 pathway; moreover, it is the hub of such important processes as cancer, cell stress, inflammation, and chemio- and radio-resistance. That is why Keap1 has become an intriguing pharmacological target. Many recent data show that Keap1 interacts with HSP90 protein.
Bonura A, Giacomarra M, Montana G
openaire +3 more sources
Protein-Protein Docking of IKKβ and Keap1.
, 2013 (A) Complex of IKKβ and Keap1 shown as ribbon diagram. The Keap1 binding motif of IKKβ fits into an identical pocket of Keap1. (B) Superimpose of IKKβ (Dark green) and Nrf2 (yellow, PDB ID: 2FLU) ETGE motif in the Keap1 cavity.
Jian-Min Jia (459013) +9 more
core +1 more source
Advanced Science, EarlyView.Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren +11 more
wiley +1 more source
Miconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells
Drug Design, Development and Therapy, 2020 Te-Fu Tsai,1,2 Po-Chun Chen,3,4 Yi-Chia Lin,1,2 Kuang-Yu Chou,1,2 Hung-En Chen,1 Chao-Yen Ho,1,5 Ji-Fan Lin,3 Thomas I-Sheng Hwang1,2,6 1Division of Urology, Department of Surgery, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; 2Division of ...
Tsai TF +7 more
doaj
The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway [PDF]
, 2014 SummaryKelch-like ECH-associated protein 1 (Keap1) is a ubiquitin E3 ligase specificity factor that targets transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) for ubiquitination and degradation.
Chad E. Mire +19 more
core +1 more source
Advanced Science, EarlyView.Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li +7 more
wiley +1 more source
Keap1 mutations in lung cancer patients
Oncology Letters, 2013 Kelch-like ECH-associated protein 1 (Keap1) inhibits nuclear factor erythroid 2-related 2 (NEF2L2; also named NRF2)-induced cytoprotection and has been hypothesized to represent a candidate tumor suppressor. We have previously reported the somatic mutations of the NRF2 gene (NFE2L2), however, the correlation between the Keap1 mutation and the ...
SASAKI, HIDEFUMI +7 more
openaire +3 more sources
Advanced Science, EarlyView.Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai +12 more
wiley +1 more source