Results 71 to 80 of about 50,990 (303)
Advanced Science, EarlyView.This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan +10 more
wiley +1 more source
Essential Role of Keap1-Nrf2 Signaling in Mood Disorders: Overview and Future Perspective
Frontiers in Pharmacology, 2018 Depression is one of the most common mood disorders with a high rate of relapse. Accumulating evidence suggests that the transcription factor Kelch-like erythroid cell-derived protein with CNC homology (ECH)-associated protein 1 (Keap1)-Nuclear factor ...
Kenji Hashimoto
doaj +1 more source
Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation
Cell Communication and Signaling, 2020 Background and purpose Targeted therapy and immunotherapy have led to dramatic change in the treatment of lung cancer, however, the overall 5-year survival rate of lung cancer patients is still suboptimal.
Meiling Gong +7 more
doaj +1 more source
Advanced Science, EarlyView.A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu +15 more
wiley +1 more source
The potential roles of Nrf2/Keap1 signaling in anticancer drug interactions
Current Research in Pharmacology and Drug Discovery, 2021 Nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), together with its suppressive binding partner Kelch-like ECH-associated protein 1 (Keap1), regulates cellular antioxidant response and drug metabolism. The roles of Nrf2/Keap1 signaling in the
Jingya Wang +5 more
doaj +1 more source
Nature Communications, 2023 Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor responsible for mounting an anti-oxidation gene expression program to counter oxidative stress.
Changzhou Cai +8 more
semanticscholar +1 more source
Protein-Protein Docking of IKKβ and Keap1.
, 2013 (A) Complex of IKKβ and Keap1 shown as ribbon diagram. The Keap1 binding motif of IKKβ fits into an identical pocket of Keap1. (B) Superimpose of IKKβ (Dark green) and Nrf2 (yellow, PDB ID: 2FLU) ETGE motif in the Keap1 cavity.
Jian-Min Jia (459013) +9 more
core +1 more source
REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma
Advanced Science, EarlyView.Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu +20 more
wiley +1 more source
Drug Delivery, 2019 In the current experimental study, we scrutinized the chemoprotective effect of astraxanthin against the 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer via Nrf-2-Keap1 and NF-kB and mTOR/Maf-1/PTEN pathway.
Tao Sun +4 more
doaj +1 more source
Cancers, 2023 Simple Summary Several studies showed that oxidative stress is involved in cancer occurrence, development, progression chemoresistance and radio resistance. The nuclear factor erythroid 2-related factor 2 (NRF2)/KEAP1 (Kelch-Like ECH-Associated Protein 1)
G. Tossetta +3 more
semanticscholar +1 more source