Results 91 to 100 of about 45,202 (305)
Molecular basis of the Keap1–Nrf2 system [PDF]
Free Radical Biology and Medicine, 2015 Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. Nrf2 induces the expression of detoxification and antioxidant enzymes, and Keap1 (Kelch-like ECH-associated protein 1), an adaptor subunit of Cullin 3-based E3 ubiquitin ligase, regulates Nrf2 activity. Keap1 also acts as a sensor for oxidative and
Takafumi, Suzuki, Masayuki, Yamamoto
openaire +2 more sources
Effect of L353A mutation on association of IKKβ with Keap1 and autophagic degradation.
, 2018 (A) Effect of L353A mutation on IKKβ-Keap1 binding. Cells were transfected with wild type or mutated HA-IKKβ(L353A) together with Flag-IKKα, Flag-IKKβ, Flag-NEMO/IKKγ, and Flag-Keap1.
Yoshihiro Tsuchiya (748923) +6 more
core +1 more source
Advanced Science, EarlyView.The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin +13 more
wiley +1 more source
BiomoleculesIsorhamnetin (ISO) is an active flavonoid compound mainly isolated from the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L. Previous studies have revealed the antifibrotic action of ISO in the liver and lungs, although its potential ...
Zhen Zhang +10 more
doaj +1 more source
Redox Biology, 2020 Development of Keap1–Nrf2 interaction inhibitors is a promising strategy for the discovery of therapeutic agents against oxidative stress-mediated diseases. Two motifs of Nrf2, ETGE and DLG motif, are responsible for Keap1-Nrf2 binding.
Yan Wang +5 more
doaj +1 more source
Epigenetic regulation of Keap1-Nrf2 signaling [PDF]
Free Radical Biology and Medicine, 2015 The kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling axis serves as a "master regulator" in response to oxidative/electrophilic stresses and chemical insults through the coordinated induction of a wide array of cytoprotective genes.
Yue, Guo +3 more
openaire +2 more sources
In vitro and in vivo validation of Keap1 knockdown by Keap1-specific siRNAs.
, 2016 (A-B) Dose-response curves upon transfection of Hepa1c1c7 cells with Keap1-specific siRNA molecules. Relative Keap1 expression inhibited by (A) the modified siKeap1-1* siRNA and its unmodified form (siKeap1-1) and (B) the modified siKeap1-2* siRNA and ...
Maria Brachs (3332712) +10 more
core +1 more source
Advanced Science, EarlyView.ALDH2, which is overexpressed in multiple myeloma, competitively binds KEAP1 to stabilize NRF2 by blocking its ubiquitin‐proteasomal degradation. Stabilized NRF2 translocates into the nucleus to upregulate the expression of GPX4. In parallel, NRF2 binds to the ALDH2 promoter to regulate its transcription, forming a positive feedback loop that represses
Ruonan Shao +10 more
wiley +1 more source
Animal Research and One Health, EarlyView.Dietary glutamine (Gln) supplementation increased the ATP levels and promoted cell proliferation in the rumen epithelium of feed‐restricted yaks. Besides, Gln inhibited ROS accumulation and reduced oxidative damage and apoptosis in the rumen epithelium of feed‐restricted yaks.
Ziqi Yue +10 more
wiley +1 more source
Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma
, 2018 The Kelch-like ECH-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) system has a wide variety of effects in addition to the oxidative stress response, such as growth promotion and chemoresistance of cancer cells.
Keiko Taguchi +5 more
core +1 more source