Results 91 to 100 of about 50,990 (303)

Effect of SKI-II on Keap1.

, 2014
A. Nuclear fractions from BEAS2B cells treated with SKI-II (1 µM) at increasing times (10–120 min) were analysed for Keap1 and Nrf2 expression and normalized using TBP (nuclear).
Keitaro Ueda (520137), Genki Kimura (520139), Yeping Xiong (520138), Peter J. Barnes (149200), Nicolas Mercado (149195), Yasuo Kizawa (520136), Audric Moses (520140), Kazuhiro Ito (149202), Jonathan M. Curtis (520141)   +8 more
core   +2 more sources

Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma

Cell Death and Disease, 2022
Keap1 mutations regulate Nrf2 activity and lead to chemoresistance in cancers. Yet the underlying molecular mechanisms of chemoresistance are poorly explored.
Syed S. Islam, Khawlah Qassem, Shafiqul Islam, Rashed R. Parag, Mohammed Z. Rahman, Walid A. Farhat, Herman Yeger, Abdelilah Aboussekhra, Bedri Karakas, Abu Shadat M. Noman   +9 more
doaj   +1 more source

Statistical analysis of Keap1 expression and Keap1 methylation level s in CSCC.

, 2015
Statistical analysis of Keap1 expression and Keap1 methylation level s in CSCC.
Jun-Qi Ma (135472), Jian-He Zheng (780674), Ayshamgul Hasim (135464), Hatila Tuersun (780672), Shu-Juan Jiao (780673), Jing-Bao xiao (780675)   +5 more
core   +1 more source

EIAV-Rev interacts with Keap1 but not Nrf2.

, 2022
(A) PLA assay was used to analyze the interactions between Rev and Keap1 or Nrf2. The red spots represent interacting complexes of the examined proteins. The nuclei were stained with DAPI (blue).
Xue-Feng Wang (488982), Ting Qi (537915), Jiaqi Zhang (412762), Yan Wang (15435), Lei Na (9287768), Xing Guo (103312), Guanqin Ma (12066344), Cheng Du (19060), Cong Liu (66219), Yuezhi Lin (9287759), Xiaojun Wang (50332)   +10 more
core   +1 more source

Spectroscopic and In Silico Determination of the Structural and Antioxidant Properties of Essential Oils From Lavandula Species Cultivated in the Silivri Region of Istanbul

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Plants are important sources of bioactive compounds that contribute to nutrition, health maintenance, and disease prevention. In this study, the chemical composition and antioxidant potential of essential oils obtained from Lavandula angustifolia “Sevtopolis” and Lavandula × intermedia cultivated in the Silivri region of Istanbul were ...
Bilge Bicak, Beray Kizilkaya, Serda Kecel Gunduz, Aliye Demet Demirag, Sabriye Percin Ozkorucuklu   +4 more
wiley   +1 more source

Detection of thermal shift in cellular Keap1 by protein-protein interaction inhibitors using immunoblot- and fluorescence microplate-based assays

STAR Protocols, 2022
Summary: Pharmacologic inhibition of the protein-protein interaction (PPI) interface of the Keap1:Nrf2 complex, which leads to Nrf2 activation and cytoprotective gene expression, offers a promising strategy for disease prevention and treatment.
Sharadha Dayalan Naidu, Dina Dikovskaya, Terry W. Moore, Albena T. Dinkova-Kostova   +3 more
doaj   +1 more source

Modulation of NRF2/KEAP1 Signaling by Phytotherapeutics in Periodontitis

Antioxidants
Periodontitis affects up to 40% of adults over 60 years old and is a consequence of gingivitis. Periodontitis is characterized by a chronic inflammation, periodontal damage, and alveolar bone resorption.
G. Tossetta, S. Fantone, L. Togni, Andrea Santarelli, Fabiola Olivieri, D. Marzioni, M. R. Rippo   +6 more
semanticscholar   +1 more source

Rev-competitive inhibition antagonizes Nrf2 binding to Keap1.

, 2022
(A-B) Biolayer interferometry graphs showing association and dissociation steps using different concentrations of Nrf2 (A) or Rev (B) to Keap1 immobilized on the anti-streptavidin biosensors.
Xue-Feng Wang (488982), Ting Qi (537915), Jiaqi Zhang (412762), Yan Wang (15435), Lei Na (9287768), Xing Guo (103312), Guanqin Ma (12066344), Cheng Du (19060), Cong Liu (66219), Yuezhi Lin (9287759), Xiaojun Wang (50332)   +10 more
core   +1 more source

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source

Regulation of P-glycoprotein by Bajijiasu in vitro and in vivo by activating the Nrf2-mediated signalling pathway

Pharmaceutical Biology, 2019
Context: Bajijiasu (BJJS), a main bioactive compound from Morinda officinalis F.C. How. (Rubiaceae), is widely administered concomitantly with other drugs for treating male impotence, female infertility, fatigue, chronic rheumatism, depression, etc ...
Xin Yang, Guoyan Hu, Lijuan Lv, Ting Liu, Longkai Qi, Guozhan Huang, Dongqing You, Jun Zhao   +7 more
doaj   +1 more source