Results 81 to 90 of about 50,990 (303)

Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.

, 2016
Mammalian BET proteins comprise a family of bromodomain-containing epigenetic regulators with complex functions in chromatin organization and gene regulation.
Kerstin Spirohn, Nirmalya Chatterjee, Michael Boutros (7610), Min Tian (438923), Nirmalya Chatterjee (171737), Min Tian, Dirk Bohmann (171743), Michael Boutros, Dirk Bohmann, Kerstin Spirohn (572499)   +9 more
core   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Effect of Low-Level Laser Therapy on the Nrf2/Keap1 Pathway in NMRI Mice with Testicular Torsion [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Testicular torsion (TT) is a urological emergency characterized by twisting of the spermatic cord, which reduces blood flow and leads to testicular ischemia.
Mohammad Bayat, Mahsa Soltani, Roohollah Torabi, maryam baazm, Mitra Barzroodi   +4 more
doaj  

Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer

Frontiers in Oncology
The Keap1-Nrf2 signaling pathway is a major regulator of the cytoprotective response, participating in endogenous and exogenous stress caused by ROS (reactive oxygen species). Nrf2 is the core of this pathway.
Feilong Chen, Mei Xiao, Shaofan Hu, Meng Wang   +3 more
semanticscholar   +1 more source

Clinical efficacy of atezolizumab plus bevacizumab and chemotherapy in KRAS-mutated non-small cell lung cancer with STK11, KEAP1, or TP53 comutations: subgroup results from the phase III IMpower150 trial

Journal for ImmunoTherapy of Cancer, 2022
Background The efficacy of atezolizumab (A) and/or bevacizumab (B) with carboplatin/paclitaxel (CP) chemotherapy was explored in the phase III, randomized IMpower150 study in patients with non-squamous non-small cell lung cancer (NSCLC) according to KRAS
H. West, M. McCleland, F. Cappuzzo, M. Reck, T. Mok, R. Jotte, M. Nishio, Eugene Kim, S. Morris, W. Zou, D. Shames, M. Das Thakur, G. Shankar, M. Socinski   +13 more
semanticscholar   +1 more source

Preparation, Component Identification, and Antioxidant Activity of Anthocyanins From Punica granatum “Tunisia”

AgriFood: Journal of Agricultural Products for Food, EarlyView.
The preparation for Tunisian pomegranate anthocyanin extract. The molecular mechanisms underlying the antioxidant effects of these compounds were investigated using network pharmacology and molecular docking. Antioxidant activity was evaluated through DPPH, ABTS, and FRAP assays, whereas the effects on oxidative stress and inflammation were examined in
Jing Zhang, Xu‐han Yang, Meng‐qi Zhang, Xu Guo, Ning‐yang Li, Fang‐yu Long, Chao Liu   +6 more
wiley   +1 more source

Miconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells

Drug Design, Development and Therapy, 2020
Te-Fu Tsai,1,2 Po-Chun Chen,3,4 Yi-Chia Lin,1,2 Kuang-Yu Chou,1,2 Hung-En Chen,1 Chao-Yen Ho,1,5 Ji-Fan Lin,3 Thomas I-Sheng Hwang1,2,6 1Division of Urology, Department of Surgery, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; 2Division of ...
Tsai TF, Chen PC, Lin YC, Chou KY, Chen HE, Ho CY, Lin JF, Hwang TIS   +7 more
doaj  

Diminished Efficacy of Programmed Death-(Ligand)1 Inhibition in STK11- and KEAP1-Mutant Lung Adenocarcinoma Is Affected by KRAS Mutation Status

Journal of Thoracic Oncology, 2021
Introduction: STK11 and KEAP1 mutations (STK11 mutant [STK11 MUT] and KEAP1MUT) are among the most often mutated genes in lung adenocarcinoma (LUAD). Although STK11MUT has been associated with resistance to programmed death-(ligand)1 (PD-[L]1) inhibition
B. Ricciuti, K. Arbour, Jessica J. Lin, Amir Vajdi, N. Vokes, L. Hong, Jianjun Zhang, M. Tolstorukov, Yvonne Y. Li, Liam F. Spurr, A. Cherniack, G. Recondo, G. Lamberti, Xinan Wang, D. Venkatraman, J. Alessi, V. Vaz, H. Rizvi, J. Egger, A. Plodkowski, S. Khosrowjerdi, S. Digumarthy, Hyesun Park, N. Vaz, M. Nishino, L. Sholl, D. Barbie, M. Altan, J. Heymach, F. Skoulidis, J. Gainor, M. Hellmann, M. Awad   +32 more
semanticscholar   +1 more source

p62-mediated selective autophagy is endogenously induced in viral latency and correlates with ROS-Keap1-NRF2 pathway activity.

, 2019
A. Endogenous ROS production in viral latency was measured by flow cytometry with the CellRox Green reagent (Invitrogen). Three independent repeats were conducted, and representative results are shown.
Ayrianna Sparks-Wallace (6631682), Carissa Kohne (6631691), Shunbin Ning (628000), Kenton H. Hall (6631694), Jonathan P. Moorman (219560), Mary E. A. Howell (6631679), Caroline Hawkins (6631685), Zhi Q. Yao (219563), Ling Wang (56577), Camri A. Nicksic (6631688)   +9 more
core   +1 more source

Selenium Nanomaterials for Wound Healing: Synergistic Strategies from Anti‐Infection to Tissue Regeneration

Advanced NanoBiomed Research, EarlyView.
Selenium nanoparticles (SeNPs) are emerging as multifunctional platforms for wound healing, integrating antimicrobial, anti‐inflammatory, and proregenerative activities. This review summarises key mechanisms and recent advances in SeNP‐enabled composite dressings, immunomodulatory nanocomposites, microenvironment‐responsive hydrogels, photothermal and ...
Yangxia Chen, Xiaoshuang Liang, Sirui Li, Shuoshan Li, Wei Liu, Yingping Lin, Siqi Li, Zehang Zhang, Judun Zheng, Tianfeng Chen, Rongyi Chen   +10 more
wiley   +1 more source