Results 81 to 90 of about 45,202 (305)

Electrophilic metabolites targeting the KEAP1/NRF2 partnership [PDF]

Numerous electrophilic metabolites are formed during cellular activity, particularly under conditions of oxidative, inflammatory and metabolic stress.
Dinkova-Kostova, Albena; id_orcid, Hakomäki, Henriikka, Levonen, Anna-Liisa   +2 more
core   +1 more source

Spatial Au+ Mapping Reveals a Self‐Amplifying Anti‐Tumor Immunity Loop Driven by Au(I) Complexes

Advanced Science, EarlyView.
The first report of spatial Au+ mapping of a representative gold complex (Au9). Macrophages, DCs, and tumor cells ranked as the top three in Au+ enrichment after Au9 treatment. Interestingly, Au9 treatment could induce ferroptosis and suppress cellular cholesterol, further eliciting a self‐amplifying anti‐tumor immunity loop.
Zhongren Xu, Zhiyue Fan, Lin Lv, Wei Lu, Zhenfan Wen, Wukun Liu   +5 more
wiley   +1 more source

Regulation of P-glycoprotein by Bajijiasu in vitro and in vivo by activating the Nrf2-mediated signalling pathway

Pharmaceutical Biology, 2019
Context: Bajijiasu (BJJS), a main bioactive compound from Morinda officinalis F.C. How. (Rubiaceae), is widely administered concomitantly with other drugs for treating male impotence, female infertility, fatigue, chronic rheumatism, depression, etc ...
Xin Yang, Guoyan Hu, Lijuan Lv, Ting Liu, Longkai Qi, Guozhan Huang, Dongqing You, Jun Zhao   +7 more
doaj   +1 more source

Lung adenocarcinoma patients with KEAP1 mutation harboring low immune cell infiltration and low activity of immune environment

Thoracic Cancer, 2021
Background Kelch‐like ECH‐associated protein 1 (KEAP1) has been identified as a cancer driver gene in lung adenocarcinoma (LUAD), and increased evidence has given us clues about the association of KEAP1 mutation and immune characteristics.
Wanwan Cheng, Bin Xu, Haitao Zhang, Shencun Fang   +3 more
doaj   +1 more source

Influence of Keap1 mutations on dipeptidyl peptidase III interaction

, 2022
Dipeptidil-peptidaza III osim cijepanja dipeptida s N-terminalnog kraja oligopeptida ima i ulogu u regulaciji signalnog puta Keap1-Nrf2. Nrf2 je transkripcijski faktor koji je ključan u odgovoru stanice na oksidacijska oštećenja, a vežući se na protein ...
Kolak, Martina
core   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma

Cell Death and Disease, 2022
Keap1 mutations regulate Nrf2 activity and lead to chemoresistance in cancers. Yet the underlying molecular mechanisms of chemoresistance are poorly explored.
Syed S. Islam, Khawlah Qassem, Shafiqul Islam, Rashed R. Parag, Mohammed Z. Rahman, Walid A. Farhat, Herman Yeger, Abdelilah Aboussekhra, Bedri Karakas, Abu Shadat M. Noman   +9 more
doaj   +1 more source

Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein. [PDF]

, 2016
Mammalian BET proteins comprise a family of bromodomain-containing epigenetic regulators with complex functions in chromatin organization and gene regulation.
Kerstin Spirohn, Nirmalya Chatterjee, Michael Boutros (7610), Min Tian (438923), Nirmalya Chatterjee (171737), Min Tian, Dirk Bohmann (171743), Michael Boutros, Dirk Bohmann, Kerstin Spirohn (572499)   +9 more
core   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Effect of Resistance and Endurance Trainings on Nrf2/Keap1 Signaling Pathway in Testicular Tissue of Type 2 Diabetic Rats

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: The antioxidant Nrf2/Keap1 pathway prevents cellular damages against oxidative stress and this pathway is disrupted following diabetes.
Zahra Nadi, Yusef Abbasi, Farideh Jalali Mashayekhi, Mohammad Bayat, Parvindokht Bayat, Maryam Baazm   +5 more
doaj