Results 101 to 110 of about 45,202 (305)

KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition

, 2021
Summary: Metabolic reprogramming in cancer cells can create metabolic liabilities. KEAP1-mutant lung cancer is refractory to most current therapies. Here we show that KEAP1 deficiency promotes glucose dependency in lung cancer cells, and KEAP1-mutant ...
Kellen Olszewski, Xiaoguang Liu, Molina Das, Boyi Gan, Yilei Zhang, Lavanya Kondiparthi, Guang Lei, Pranavi Koppula, Bingliang Fang, Masha V. Poyurovsky   +9 more
core   +1 more source

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

Keap1 modulates the redox cycle and hepatocyte cell cycle in regenerating liver [PDF]

, 2014
Keap1 negatively controls the activity of transcription factor Nrf2. This Keap1/Nrf2 pathway plays a critical role in combating oxidative stress. We aimed at determining whether and how Keap1 modulates the cell cycle of replicating hepatocytes during ...
Zou, Yuhong, Hu, Min, Dai, Guoli, Yang, Yan, Lee, Joonyong, Nambiar, Shashank Manohar   +5 more
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate [PDF]

, 2016
KEAP1 is a substrate adaptor protein for a CUL3-based E3 ubiquitin ligase. Ubiquitylation and degradation of the antioxidant transcription factor NRF2 is considered the primary function of KEAP1; however, few other KEAP1 substrates have been identified ...
Mulvaney, Kathleen M., Cook, Jeanette G., Siesser, Priscila F., Matson, Jacob P., Major, Michael B., Cloer, Erica W., Jacobs, Timothy M., Tamir, Tigist Y., Harrison, Joseph S., Vaziri, Cyrus, Goldfarb, Dennis   +10 more
core   +1 more source

A proposed model for the cellular Nrf2/Keap1 axis manipulation of EIAV replication.

, 2022
Nrf2/Keap1 plays a crucial role in the management of oxidative stress. Under normal conditions, Keap1 interacts with Nrf2 in the cytoplasm, targeting it for proteasomal degradation to maintain redox homeostasis.
Xue-Feng Wang (488982), Ting Qi (537915), Jiaqi Zhang (412762), Yan Wang (15435), Lei Na (9287768), Xing Guo (103312), Guanqin Ma (12066344), Cheng Du (19060), Cong Liu (66219), Yuezhi Lin (9287759), Xiaojun Wang (50332)   +10 more
core   +1 more source

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

Innovation of plant‐derived extracellular vesicles and interdisciplinary research: From discovery to biomedical applications

BMEMat, EarlyView.
Plant‐derived extracellular vesicles offer numerous advantages and are regarded as highly promising candidates in the field of biomedicine. Abstract Extracellular vesicles (EVs) are double‐membrane vesicular structures that can be secreted by nearly all living cells.
Zilin Li, Yi Wei, Ben Hu, Yafang Song, Xiaojia Chen, Nik Ahmad Nizam Nik Malek, Tongkai Chen   +6 more
wiley   +1 more source

Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3

, 2015
The regulation of cellular stress responses to electrophiles and oxidants is mediated by the transcription factor NF-E2-related factor 2 (Nrf2), which, in turn, is regulated by CUL-E3 (CUL3) ligase-mediated ubiquitylation.
Sheryl L. Stamer (1264254), Girish Rachakonda (619635), Daniel C. Liebler (1264215), Ying Xiong (245379), Konjeti R. Sekhar (1264257), Michael L. Freeman (164199)   +5 more
core   +1 more source

Caloric Restriction-Mediated Induction of Lipid Metabolism Gene Expression in Liver is Enhanced by Keap1-Knockdown [PDF]

, 2013
Purpose: CR increases fatty acid oxidation to decrease tissue lipid content. The Nuclear factor E2-related factor 2 (Nrf2)-Kelch like ECH associated Protein 1 (Keap1) pathway is an antioxidant gene regulatory pathway that has been previously investigated
Slitt, Angela L., Armstrong, Laura E., Kullkarni, Supriya R.   +2 more
core   +1 more source