Results 101 to 110 of about 50,990 (303)

Lung adenocarcinoma patients with KEAP1 mutation harboring low immune cell infiltration and low activity of immune environment

Thoracic Cancer, 2021
Background Kelch‐like ECH‐associated protein 1 (KEAP1) has been identified as a cancer driver gene in lung adenocarcinoma (LUAD), and increased evidence has given us clues about the association of KEAP1 mutation and immune characteristics.
Wanwan Cheng, Bin Xu, Haitao Zhang, Shencun Fang   +3 more
doaj   +1 more source

Keap1 is degraded with IKKβ by autophagy.

, 2018
(A) Expression of Keap1 promoted IKKβ degradation and Keap1 is degraded concomitant with IKKβ. HEK293 cells were transfected with wild type HA-KKβ and Flag-Keap1. After 18 h of transfection, 10 μg/ml CHX was added to cell culture.
Yoshihiro Tsuchiya (748923), Takafumi Suzuki (266095), Hideaki Kamata (748925), Mayu Kanamoto (6033974), Hozumi Motohashi (3140145), Yuki Nakao (6033977), Masayuki Yamamoto (168116)   +6 more
core   +1 more source

Dietary Glutamine Supplementation Alleviated Rumen Epithelium Oxidative Damage and Apoptosis Induced by Feed Restriction via Maintaining Mitochondrial Homeostasis in Female Yaks

Animal Research and One Health, EarlyView.
Dietary glutamine (Gln) supplementation increased the ATP levels and promoted cell proliferation in the rumen epithelium of feed‐restricted yaks. Besides, Gln inhibited ROS accumulation and reduced oxidative damage and apoptosis in the rumen epithelium of feed‐restricted yaks.
Ziqi Yue, Shanpeng Ke, Liyuan Shi, Rui Hu, Zhisheng Wang, Quanhui Peng, Huawei Zou, Jianxin Xiao, Yahui Jiang, Fali Wu, Yiping Tang   +10 more
wiley   +1 more source

CPDT and SF block only Keap1-mediated Nrf2 degradation and require key cysteine residues of Keap1.

, 2012
(A) Murine embryonic fibroblasts (MEF), including wild type MEF (Keap1+/+) and MEF with Keap1 knockout (Keap1−/−), were treated with vehicle, MG132 (25 µM), CPDT (50 µM) or SF (8 µM) for 6 h. Cells were then harvested for IB of Nrf2 and GAPDH.
Yuesheng Zhang (168364), Joseph D. Paonessa (168359), Yun Li (692280)   +2 more
core   +1 more source

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

Effect of Resistance and Endurance Trainings on Nrf2/Keap1 Signaling Pathway in Testicular Tissue of Type 2 Diabetic Rats

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: The antioxidant Nrf2/Keap1 pathway prevents cellular damages against oxidative stress and this pathway is disrupted following diabetes.
Zahra Nadi, Yusef Abbasi, Farideh Jalali Mashayekhi, Mohammad Bayat, Parvindokht Bayat, Maryam Baazm   +5 more
doaj  

Development of an enzyme-linked immunosorbent assay for Keap1-Nrf2 interaction inhibitors identification

Redox Biology, 2020
Development of Keap1–Nrf2 interaction inhibitors is a promising strategy for the discovery of therapeutic agents against oxidative stress-mediated diseases. Two motifs of Nrf2, ETGE and DLG motif, are responsible for Keap1-Nrf2 binding.
Yan Wang, Chu-Ying Xiao, Huang-Quan Lin, Jian-Shu Hu, Tsz-Ming Ip, David Chi-Cheong Wan   +5 more
doaj   +1 more source

Post-translational modifications of Keap1: the state of the art

Frontiers in Cell and Developmental Biology
The Keap1-Nrf2 signaling pathway plays a crucial role in cellular defense against oxidative stress-induced damage. Its activation entails the expression and transcriptional regulation of several proteins involved in detoxification and antioxidation ...
Yunjia Song, Ying Qu, Caiyun Mao, Rong Zhang, Deyou Jiang, Xutao Sun   +5 more
semanticscholar   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer

Science Advances
Loss-of-function mutations in KEAP1 frequently occur in lung cancer and are associated with poor prognosis and resistance to standard of care treatment, highlighting the need for the development of targeted therapies.
R. Pillai, Sarah E. Leboeuf, Yuan Hao, Connie New, Jenna L. E. Blum, A. Rashidfarrokhi, Shih Ming Huang, Christian Bahamon, Warren L. Wu, Burcu Karadal-Ferrena, Alberto Herrera, E. Ivanova, Michael Cross, Jozef P Bossowski, Hongyu Ding, M. Hayashi, S. Rajalingam, Triantafyllia Karakousi, V. Sayin, Kamal M. Khanna, Kwok-Kin Wong, Robert Wild, A. Tsirigos, J. Poirier, C. Rudin, Shawn M. Davidson, S. Koralov, T. Papagiannakopoulos   +27 more
semanticscholar   +1 more source