Results 111 to 120 of about 50,990 (303)
In vitro and in vivo validation of Keap1 knockdown by Keap1-specific siRNAs.
, 2016 (A-B) Dose-response curves upon transfection of Hepa1c1c7 cells with Keap1-specific siRNA molecules. Relative Keap1 expression inhibited by (A) the modified siKeap1-1* siRNA and its unmodified form (siKeap1-1) and (B) the modified siKeap1-2* siRNA and ...
Maria Brachs (3332712) +10 more
core +1 more source
Influence of Keap1 mutations on dipeptidyl peptidase III interaction
, 2022 Dipeptidil-peptidaza III osim cijepanja dipeptida s N-terminalnog kraja oligopeptida ima i ulogu u regulaciji signalnog puta Keap1-Nrf2. Nrf2 je transkripcijski faktor koji je ključan u odgovoru stanice na oksidacijska oštećenja, a vežući se na protein ...
Kolak, Martina
core +1 more source
, 2021 Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous antioxidant defense module that orchestrates the expression of ...
Gerasimos P. Sykiotis
core +1 more source
Atomically precise metal cluster enzymes for pathological tissue regeneration
BMEMat, EarlyView.Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong +11 more
wiley +1 more source
BiomoleculesIsorhamnetin (ISO) is an active flavonoid compound mainly isolated from the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L. Previous studies have revealed the antifibrotic action of ISO in the liver and lungs, although its potential ...
Zhen Zhang +10 more
doaj +1 more source
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
Molecular Mechanisms of Patient-Derived KEAP1 Superbinder Mutants
, 2017 In 30% of lung cancers, mutations in KEAP1 or NRF2 result in constitutive NRF2 activity. This promotes tumor progression, resistance to radio- and chemotherapy, and predicts poor patient outcome.
Cloer, Erica
core +1 more source
Diagnostic Cytopathology, EarlyView.ABSTRACT Introduction Lung adenocarcinoma commonly causes malignant pleural effusion (MPE), a condition with poor prognosis and limited treatment options. Pleural effusion specimens offer a minimally invasive source for diagnosis and molecular testing.
Harpreet Virk +5 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier +82 more
wiley +1 more source
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC
Cell Death and DiseaseImmunotherapy has become a prominent first-line cancer treatment strategy. In non-small cell lung cancer (NSCLC), the expression of PD-L1 induces an immuno-suppressive effect to protect cancer cells from immune elimination, which designates PD-L1 as an ...
Jinghan Li +10 more
semanticscholar +1 more source