Results 111 to 120 of about 45,202 (305)
Biological Reviews, EarlyView.ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley +1 more source
Cancer Medicine, 2019 Keap1/Nrf2 pathway regulates the antioxidant stress response, detoxification response, and energy metabolism. Previous reports found that aberrant Keap1/Nrf2 pathway activation due to Kelch‐like ECH‐associated protein 1 (Keap1) mutations or Nuclear ...
Ran Hori +9 more
doaj +1 more source
, 2022 Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, 2022, Universidade de Lisboa, Faculdade de Farmácia.
openaire +1 more source
KEAP1 negative regulation and NRF2 ubiquitination status.
, 2019 A) Western blot analysis and B) quantification of abundance of KEAP1 in the cytosolic/nuclear fractions of WT (238RM) and AT (AT28RM, AT50RM, AT129RM) cells, treated with DEX or not treated. HPRT1 and LAMIN A served as a loading control for the cytosolic/
Sara Biagiotti (4227964) +4 more
core +1 more source
Toward Fit‐for‐Purpose Data for Drug Assessment in Non‐small Cell Lung Cancer: A Core Dataset
Clinical Pharmacology &Therapeutics, EarlyView.Considering the high unmet medical need in people with non‐small cell lung cancer (NSCLC), the drug assessment for targeted therapies often rely on small populations and single‐arm trials, challenging the evaluation by regulatory authorities, health technology assessment bodies (HTAb), and clinicians.
Geeske F. Grit +6 more
wiley +1 more source
Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley +1 more source
Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou +6 more
wiley +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
The thiol modification of Keap1 Cys288 is responsible for DATS-induced activation of Nrf2 signaling.
, 2014 (A) Cells were incubated with DATS (20 µM) in the presence or the absence of DTT (50 µM). Both the nuclear localization of Nrf2 and the expression of HO-1 and NQO1 were determined by Western blot analysis.
Joydeb Kumar Kundu (194743) +7 more
core +1 more source
Mechanisms controlling the KEAP1-NRF2 signaling pathway in lung cancer [PDF]
, 2013 An ability to effectively regulate intracellular reactive oxygen species is imperative to prevent conditions of oxidative stress, and ultimately aberrant cell death.
Hast, Bridgid Elizabeth
core +1 more source