Results 31 to 40 of about 50,990 (303)

A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90

Disease Models & Mechanisms, 2022
Nrf2 is the master transcriptional regulator of cellular responses against oxidative stress. It is chiefly regulated by Keap1, a substrate adaptor protein that mediates Nrf2 degradation. Nrf2 activity is also influenced by many other protein interactions
Vy Ngo, Anne Brickenden, Hansen Liu, Cynthia Yeung, Wing-Yiu Choy, Martin L. Duennwald   +5 more
doaj   +1 more source

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration [PDF]

, 2013
Transcription factor Nrf2 and its repressor Keap1 regulate a network of cytoprotective genes involving more than 1% of the genome, their best known targets being drug-metabolizing and antioxidant genes.
Iain Hargreaves, Land, John M., Kira M. Holmström, Andrey Y. Abramov, Chalasani, A, Annapurna Chalasani, Holmstrom, KM, Masayuki Yamamoto, Baird, Liam, Baird, L, John M. Land, Yamamoto, Masayuki, Lee Stanyer, Land, JM, Dinkova-Kostova, AT, Holmström, Kira M., Liam Baird, Albena T. Dinkova-Kostova, Ying Zhang, Abramov, Andrey Y., Zhang, Y, Hargreaves, Iain, Chalasani, Annapurna, Abramov, AY, Stanyer, L, Hargreaves, IP, Yamamoto, M, Zhang, Ying, Stanyer, Lee, Dinkova-Kostova, Albena T.; id_orcid   +29 more
core   +1 more source

Protective effects of N-acetyl-l-cysteine against penconazole-triggered hepatorenal toxicity in adult rats

Journal of Veterinary Research, 2023
Penconazole (PEN) is a widely applied triazole fungicide. This study sought to define the efficacy of N-acetyl-l-cysteine (NAC) in mitigating PEN-triggered hepatorenal toxicity in rats.
Morgan Ashraf M., Ogaly Hanan A., Kamel Shaimaa, Rashad Maha M., Hassanen Eman I., Ibrahim Marwa A., Galal Mona K., Yassin Aya M., Dulmani Sharah A. Al, Al-Zahrani Fatimah A.M., Hussien Ahmed M.   +10 more
doaj   +1 more source

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.

Physiological Reviews, 2018
The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system forms the major node of cellular and organismal defense against oxidative and electrophilic stresses of both exogenous and endogenous origins.
Masayuki Yamamoto, T. Kensler, H. Motohashi   +2 more
semanticscholar   +1 more source

KEAP1/NRF2 as a druggable target [PDF]

Arhiv za farmaciju, 2023
Nuclear factor erythroid 2-related factor 2 (NRF2; encoded by NFE2L2) is an inducible transcription factor that regulates the expression of a large network of genes encoding proteins with cytoprotective functions.
Dinkova-Kostova Albena T.
doaj  

Nrf2/Keap1/ARE signaling: Towards specific regulation

Life Science, 2021
The Nrf2 transcription factor governs the expression of hundreds genes involved in cell defense against oxidative stress, the hallmark of numerous diseases such as neurodegenerative, cardiovascular, some viral pathologies, diabetes and others.
A. V. Ulasov, A. A. Rosenkranz, G. Georgiev, A. S. Sobolev   +3 more
semanticscholar   +1 more source

Modulation of NRF2/KEAP1 Signaling in Preeclampsia

Cells, 2023
Placentation is a key and tightly regulated process that ensures the normal development of the placenta and fetal growth. Preeclampsia (PE) is a hypertensive pregnancy-related disorder involving about 5–8% of all pregnancies and clinically characterized ...
G. Tossetta, S. Fantone, F. Piani, C. Crescimanno, A. Ciavattini, S. Giannubilo, D. Marzioni   +6 more
semanticscholar   +1 more source

Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease

FASEB BioAdvances, 2019
Bicaudal D1 (BICD1), an adaptor for the dynein‐dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD).
Nicolas Mercado, Thomas Colley, Jonathan R. Baker, Chaitanya Vuppussetty, Yuta Kono, Colin Clarke, Sharon Tooze, Terje Johansen, Peter J. Barnes   +8 more
doaj   +1 more source

Astragaloside IV mitigates cerebral ischaemia-reperfusion injury via inhibition of P62/Keap1/Nrf2 pathway-mediated ferroptosis.

European Journal of Pharmacology, 2023
Cerebral ischaemia-reperfusion injury (CIRI) is a critical component of ischaemic stroke pathogenesis. Ferroptosis contributes to and aggravates CIRI, whereas the P62/Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor 2 (Nrf2) pathway ...
Lele Wang, Canwen Liu, Linlin Wang, Biao Tang   +3 more
semanticscholar   +1 more source

MCL attenuates atherosclerosis by suppressing macrophage ferroptosis via targeting KEAP1/NRF2 interaction

Redox Biology, 2023
Background Micheliolide (MCL), which is the active metabolite of parthenolide, has demonstrated promising clinical application potential. However, the effects and underlying mechanisms of MCL on atherosclerosis are still unclear. Method ApoE−/− mice were
Xing Luo, Yuehong Wang, Xinxin Zhu, Yuwu Chen, Biyi Xu, XiaoXuan Bai, Xiuzhu Weng, Jin-mei Xu, Yangyang Tao, Dan Yang, Jie Du, Ying Lv, Sha Zhang, Sining Hu, Ji Li, H. Jia   +15 more
semanticscholar   +1 more source