Molecular evolution of Keap1 - Two Keap1 molecules with distinctive intervening region structures are conserved among fish [PDF]
Journal of Biological Chemistry, 2008 Keap1 is a BTB-Kelch-type substrate adaptor protein of the Cul3-dependent ubiquitin ligase complex. Keap1 facilitates the degradation of Nrf2, a transcription factor regulating the inducible expression of many cytoprotective genes.
Kaneko Hiroshi +6 more
core +3 more sources
Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation [PDF]
Cell Communication and Signaling, 2020 Background and purpose Targeted therapy and immunotherapy have led to dramatic change in the treatment of lung cancer, however, the overall 5-year survival rate of lung cancer patients is still suboptimal.
Meiling Gong +7 more
doaj +3 more sources
Keap1/Nrf2 Signaling Pathway [PDF]
Antioxidants, 2021 Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous antioxidant defense module that orchestrates the expression of cytoprotective genes to maintain homeostasis [...]
openaire +4 more sources
Open Medicine, 2023 The miR-141-3p has been reported to participate in regulating autophagy and tumor-stroma interactions in ovarian cancer (OC). We aim to investigate whether miR-141-3p accelerates the progression of OC and its effect on macrophage 2 polarization by ...
Zhao Jingyun +6 more
doaj +1 more source
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease [PDF]
Open Biology, 2020 Redox imbalance and persistent inflammation are the underlying causes of most chronic diseases. Mammalian cells have evolved elaborate mechanisms for restoring redox homeostasis and resolving acute inflammatory responses.
Sharadha Dayalan Naidu +1 more
doaj +1 more source
Keap1 inhibition attenuates glomerulosclerosis [PDF]
Nephrology Dialysis Transplantation, 2014 NFE2-related factor 2 (Nrf2) is a master regulatory transcription factor for antioxidant genes. Inhibition of its adaptor protein, Kelch-like ECH-associated protein 1 (Keap1), activates Nrf2. Podocyte injury triggers the progressive deterioration of glomerular damage toward glomerulosclerosis. We examined whether modulation of the Keap1-Nrf2 system has
Yoichi, Miyazaki +11 more
openaire +2 more sources
Computational study of Curcuma zanthorrhiza Roxb compounds as potential antidiabetic towards alpha-amylase, alpha-glucosidase, and Keap1 inhibition [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: Curcuma zanthorrhiza Roxb is traditionally used as a medicinal herb that is believed might cure some diseases. However, there is still a lack of information about the underlying mechanism of bioactive compounds from C.
Sasangka Prasetyawan +2 more
doaj
Tributyltin activates the Keap1–Nrf2 pathway via a macroautophagy-independent reduction in Keap1
The Journal of Toxicological Sciences, 2023 Tributyltin (TBT) is an environmental chemical, which was used as an antifouling agent for ships. Although its use has been banned, it is still persistently present in ocean sediments. Although TBT reportedly causes various toxicity in mammals, few studies on the mechanisms of biological response against TBT toxicity exist.
Misaki, Hatano +3 more
openaire +2 more sources
Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder [PDF]
, 2020 Autism Spectrum Disorder (ASD) is one of the most common neurodevelopmental disorders with no drugs treating the core symptoms and no validated biomarkers for clinical use.
Connors, Susan L. +7 more
core +3 more sources
HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents [PDF]
, 2014 The NRF2 signalling cascade provides a primary response against electrophilic chemicals and oxidative stress. The activation of NRF2-signaling is anticipated to have adverse clinical consequences; NRF2 is activated in a number of cancers and ...
Campbell, Kathryn H. +5 more
core +7 more sources