Results 11 to 20 of about 45,202 (305)
Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles [PDF]
Antioxidants, 2022 KEAP1 is a cytoplasmic protein that functions as an adaptor for the Cullin-3-based ubiquitin E3 ligase system, which regulates the degradation of many proteins, including NFE2L2/NRF2 and p62/SQSTM1.
Elisabet Uribe-Carretero +12 more
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WDR23 regulates NRF2 independently of KEAP1 [PDF]
PLOS Genetics, 2017 Cellular adaptation to stress is essential to ensure organismal survival. NRF2/NFE2L2 is a key determinant of xenobiotic stress responses, and loss of negative regulation by the KEAP1-CUL3 proteasome system is implicated in several chemo- and radiation-resistant cancers. Advantageously using C.
Jacqueline Y. Lo +2 more
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Detection of thermal shift in cellular Keap1 by protein-protein interaction inhibitors using immunoblot- and fluorescence microplate-based assays [PDF]
STAR Protocols, 2022 Summary: Pharmacologic inhibition of the protein-protein interaction (PPI) interface of the Keap1:Nrf2 complex, which leads to Nrf2 activation and cytoprotective gene expression, offers a promising strategy for disease prevention and treatment.
Sharadha Dayalan Naidu +3 more
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Quantum Chemical Studies and Pharmacophore Modeling for Designing Novel Keap1 Antagonists that Enhance Nrf2 Mediated Neuroprotection [PDF]
, 2021 In recent years, the significance of oxidative stress in the pathophysiology of Neurodegenerative/developmental disorders like Attention Deficit Hyperactivity Disorder, Parkinson\u27s and Alzheimer\u27s is being studied at an accelerating pace.
FNU, Srinidhi
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Keap1/Nrf2 Signaling Pathway [PDF]
Antioxidants, 2021 Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous antioxidant defense module that orchestrates the expression of cytoprotective genes to maintain homeostasis [...]
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Roles of autophagy and p62 /SQSTM1 in hepatic ischemia-reperfusion
生物医学转化, 2021 Autophagy is a lysosomal dependent degradation system, and p62 itself is an importantprotein carrier to facilitate the removal of damaged proteins by proteasomes and autophagosomes. p62 playsan important role in selective autophagy such as mitochondrial
Zhang Haiming, Zhu Zhijun
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Computational study of Curcuma zanthorrhiza Roxb compounds as potential antidiabetic towards alpha-amylase, alpha-glucosidase, and Keap1 inhibition [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: Curcuma zanthorrhiza Roxb is traditionally used as a medicinal herb that is believed might cure some diseases. However, there is still a lack of information about the underlying mechanism of bioactive compounds from C.
Sasangka Prasetyawan +2 more
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Antioxidants, 2022 NF-E2-related factor 2 (NRF2), an antioxidant transcription factor, is activated in autophagy-deficient mice due to the accumulations of p62/SQSTM1 and its subsequent interaction with Kelch-like-ECH-associated protein 1 (KEAP1), an adaptor component for ...
Eun Young Kim, Jae Man Lee
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The KEAP1–NRF2 System in Cancer [PDF]
Frontiers in Oncology, 2017 Cancer cells first adapt to the microenvironment and then propagate. Mutations in tumor suppressor genes or oncogenes are frequently found in cancer cells. Comprehensive genomic analyses have identified somatic mutations and other alterations in the KEAP1 or NRF2 genes and in well-known tumor suppressor genes or oncogenes, such as TP53, CDKN2A, PTEN ...
Taguchi, Keiko, Yamamoto, Masayuki
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Tributyltin activates the Keap1–Nrf2 pathway via a macroautophagy-independent reduction in Keap1
The Journal of Toxicological Sciences, 2023 Tributyltin (TBT) is an environmental chemical, which was used as an antifouling agent for ships. Although its use has been banned, it is still persistently present in ocean sediments. Although TBT reportedly causes various toxicity in mammals, few studies on the mechanisms of biological response against TBT toxicity exist.
Hatano, Misaki +3 more
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