Results 11 to 20 of about 50,990 (303)
Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles [PDF]
Antioxidants, 2022 KEAP1 is a cytoplasmic protein that functions as an adaptor for the Cullin-3-based ubiquitin E3 ligase system, which regulates the degradation of many proteins, including NFE2L2/NRF2 and p62/SQSTM1.
Elisabet Uribe-Carretero +12 more
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Battles against aberrant KEAP1-NRF2 signaling in lung cancer: intertwined metabolic and immune networks [PDF]
Theranostics, 2023 The Kelch-like ECH-associated protein 1/nuclear factor erythroid-derived 2-like 2 (KEAP1/NRF2) pathway is well recognized as a key regulator of redox homeostasis, protecting cells from oxidative stress and xenobiotics under physiological circumstances ...
Ke Xu +5 more
semanticscholar +2 more sources
Electrophilic metabolites targeting the KEAP1/NRF2 partnership. [PDF]
Current Opinion in Chemical BiologyNumerous electrophilic metabolites are formed during cellular activity, particularly under conditions of oxidative, inflammatory and metabolic stress.
A. Dinkova-Kostova +2 more
semanticscholar +2 more sources
Molecular Basis of the KEAP1-NRF2 Signaling Pathway
Molecules and Cells, 2023 Transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. NRF2 induces expression of detoxification and antioxidant enzymes and suppresses inductions of pro-inflammatory cytokine genes.
Takafumi Suzuki +2 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Chronic obstructive pulmonary disease (COPD) is a severely disabling chronic lung disease characterized by persistent airway inflammation, which leads to limited expiratory airflow that deteriorates over time.
Yifan Xu +10 more
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p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control
Molecular & Cellular Oncology, 2021 Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear ...
Eeva-Liisa Eskelinen +2 more
doaj +1 more source
Redox Report, 2021 Background Progression of Benign Prostate hyperplasia (BPH) is vulnerable to oxidative stress (OS) and prostatic enlargement among the aging males through apoptosis deregulation.
Nabila Jahan +5 more
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Roles of autophagy and p62 /SQSTM1 in hepatic ischemia-reperfusion
生物医学转化, 2021 Autophagy is a lysosomal dependent degradation system, and p62 itself is an importantprotein carrier to facilitate the removal of damaged proteins by proteasomes and autophagosomes. p62 playsan important role in selective autophagy such as mitochondrial
Zhang Haiming, Zhu Zhijun
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Computational study of Curcuma zanthorrhiza Roxb compounds as potential antidiabetic towards alpha-amylase, alpha-glucosidase, and Keap1 inhibition [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: Curcuma zanthorrhiza Roxb is traditionally used as a medicinal herb that is believed might cure some diseases. However, there is still a lack of information about the underlying mechanism of bioactive compounds from C.
Sasangka Prasetyawan +2 more
doaj
Redox Biology, 2023 Background Sepsis is a fatal disease with a high rate of morbidity and mortality, during which acute lung injury is the earliest and most serious complication. Injury of pulmonary microvascular endothelial cells (PMVECs) induced by excessive inflammation
K. Shen +19 more
semanticscholar +1 more source