Results 11 to 20 of about 35,325 (217)

NRF2 Activation in Autophagy Defects Suppresses a Pharmacological Transactivation of the Nuclear Receptor FXR

Antioxidants, 2022
NF-E2-related factor 2 (NRF2), an antioxidant transcription factor, is activated in autophagy-deficient mice due to the accumulations of p62/SQSTM1 and its subsequent interaction with Kelch-like-ECH-associated protein 1 (KEAP1), an adaptor component for ...
Eun Young Kim, Jae Man Lee
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miR-141-3p accelerates ovarian cancer progression and promotes M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway

Open Medicine, 2023
The miR-141-3p has been reported to participate in regulating autophagy and tumor-stroma interactions in ovarian cancer (OC). We aim to investigate whether miR-141-3p accelerates the progression of OC and its effect on macrophage 2 polarization by ...
Zhao Jingyun, Liu Leilei, Zhao Wei, Lv Cuiting, Zhang Na, Jia Xinzhuan, Zhang Zhengmao   +6 more
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A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90

Disease Models & Mechanisms, 2022
Nrf2 is the master transcriptional regulator of cellular responses against oxidative stress. It is chiefly regulated by Keap1, a substrate adaptor protein that mediates Nrf2 degradation. Nrf2 activity is also influenced by many other protein interactions
Vy Ngo, Anne Brickenden, Hansen Liu, Cynthia Yeung, Wing-Yiu Choy, Martin L. Duennwald   +5 more
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Protective effects of N-acetyl-l-cysteine against penconazole-triggered hepatorenal toxicity in adult rats

Journal of Veterinary Research, 2023
Penconazole (PEN) is a widely applied triazole fungicide. This study sought to define the efficacy of N-acetyl-l-cysteine (NAC) in mitigating PEN-triggered hepatorenal toxicity in rats.
Morgan Ashraf M., Ogaly Hanan A., Kamel Shaimaa, Rashad Maha M., Hassanen Eman I., Ibrahim Marwa A., Galal Mona K., Yassin Aya M., Dulmani Sharah A. Al, Al-Zahrani Fatimah A.M., Hussien Ahmed M.   +10 more
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Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease

FASEB BioAdvances, 2019
Bicaudal D1 (BICD1), an adaptor for the dynein‐dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD).
Nicolas Mercado, Thomas Colley, Jonathan R. Baker, Chaitanya Vuppussetty, Yuta Kono, Colin Clarke, Sharon Tooze, Terje Johansen, Peter J. Barnes   +8 more
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KEAP1/NRF2 as a druggable target [PDF]

Arhiv za farmaciju, 2023
Nuclear factor erythroid 2-related factor 2 (NRF2; encoded by NFE2L2) is an inducible transcription factor that regulates the expression of a large network of genes encoding proteins with cytoprotective functions.
Dinkova-Kostova Albena T.
doaj  

Mutant p53–Nrf2 axis regulates the proteasome machinery in cancer

Molecular & Cellular Oncology, 2017
The proteasome machinery is a common target of gain-of-function p53 missense mutants. Upregulation of the proteasome fosters chemoresistance to proteasome inhibitors.
Kamil Lisek, Dawid Walerych, Giannino Del Sal   +2 more
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PGAM5 expression levels in heart failure and protection ROS-induced oxidative stress and ferroptosis by Keap1/Nrf2

Clinical and Experimental Hypertension, 2023
Objectives As a common and frequently occurring disease, heart failure has been paid more and more attention, but the mechanism of its occurrence and development is still unclear.
Shuangfei Li, Ping Wen, Dayong Zhang, Decai Li, Qidong Gao, Hong Liu, Yunfeng Di   +6 more
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Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles

Antioxidants, 2022
KEAP1 is a cytoplasmic protein that functions as an adaptor for the Cullin-3-based ubiquitin E3 ligase system, which regulates the degradation of many proteins, including NFE2L2/NRF2 and p62/SQSTM1.
Elisabet Uribe-Carretero, Guadalupe Martinez-Chacón, Sokhna M. S. Yakhine-Diop, Gema Duque-González, Mario Rodríguez-Arribas, Eva Alegre-Cortés, Marta Paredes-Barquero, Saray Canales-Cortés, Elisa Pizarro-Estrella, Antonio Cuadrado, Rosa Ana González-Polo, José M. Fuentes, Mireia Niso-Santano   +12 more
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Targeting Nrf2 signaling in dry eye [PDF]

International Journal of Ophthalmology
Dry eye, the most common ocular surface disease, can cause ocular surface tissue damage and discomfort symptoms and seriously affect people's quality of life. The etiology of dry eye is diverse, and its pathogenesis is complex.
Yu-Nuo Zhang, Wei-Jie Ouyang, Jiao-Yue Hu, Zu-Guo Liu   +3 more
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