Results 11 to 20 of about 108,098 (261)
The NRF2-p97-NRF2 negative feedback loop
Redox Biology, 2023 p97 is a ubiquitin-targeted ATP-dependent segregase that regulates proteostasis, in addition to a variety of other cellular functions. Previously, we demonstrated that p97 negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex, facilitating proteasomal destruction.
Aryatara Shakya +10 more
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Antioxidants, 2021 The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation.
Angela Herengt +2 more
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NRF2, a Superstar of Ferroptosis
Antioxidants, 2023 Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring when there is an imbalance of redox homeostasis in the cell. Nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2) is key for cellular antioxidant responses, which promotes downstream genes transcription by binding to their antioxidant ...
Ruihan Yan +5 more
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Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation [PDF]
Free Radical Biology and Medicine, 2017 Although critical in phagocytosis in innate immunity, reactive oxygen species (ROS) collaterally inflict damage to host phagocytes because they indiscriminate targets. Since Nrf2 increases the expression of anti-oxidant enzymes that nullifies ROS, ROS activating Nrf2 is a critical negative regulatory step for countering the deleterious effects of ROS ...
Kyun, Ha Kim +6 more
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Nrf2 Signaling in Macrophages [PDF]
Reactive Oxygen Species, 2016 The nuclear factor E2-related factor 2 (Nrf2) is known as the chief regulator of cellular antioxidant defenses as well as a suppressor of inflammation. Macrophages act as major players in inflammatory responses. Because oxidative stress and inflammation are two intertwined processes, the anti-inflammatory activity of Nrf2 signaling is believed to ...
Hong, Zhu, Zhenquan, Jia, Y Robert, Li
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Dangerous Entrapment for NRF2 [PDF]
Cell, 2016 Progerin, a mutated lamin A, causes the severe premature-aging syndrome Hutchinson-Gilford progeria (HGPS). Kubben et al. present a driving mechanism for HGPS involving trapping of NRF2 at the nuclear periphery by progerin. This local restriction results in impaired NRF2 signaling and chronic oxidative stress.
Vera, Gorbunova +2 more
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COPD lung studies of Nrf2 expression and the effects of Nrf2 activators
Inflammopharmacology, 2022 Abstract Background Nrf2 regulates cellular antioxidant defence in lung cells, including epithelial cells and alveolar macrophages (AM). The Nrf2/Keap-1 pathway can be modulated by activators with different modes of action; electrophilic compounds and protein–protein interaction (PPI) inhibitors.
Jian Li +10 more
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Pharmaceutical Biology, 2021 Context Previous studies indicate that compound Danshen Dripping Pill (CDDP) improves the adaptation to high-altitude exposure. However, its mechanism of action is not clear.
Yunhui Hu +8 more
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Opposing effects of Nrf2 and Nrf2‐activating compounds on the NLRP3 inflammasome independent of Nrf2‐mediated gene expression [PDF]
European Journal of Immunology, 2017 The transcription factor Nrf2 regulates the expression of genes required for protection from xenobiotic and oxidative stress. Under normal conditions Nrf2 is constantly degraded upon ubiquitination, mediated by the Nrf2 inhibitor Keap1. Inflammasomes represent stress‐induced protein complexes.
Garstkiewicz, Martha +7 more
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NRF2 signaling in cytoprotection and metabolism
British Journal of Pharmacology, 2023 The KEAP1-NRF2 system plays a central role in cytoprotection and defense mechanisms against oxidative stress. Because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and because NRF2 is a transcriptional factor regulating genes involved in the sulfur-mediated redox reactions, the KEAP1-NRF2 system has been regarded as a ...
Shohei Murakami +4 more
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