Results 11 to 20 of about 157,133 (211)
NRF2, a Superstar of Ferroptosis
Antioxidants, 2023 Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring when there is an imbalance of redox homeostasis in the cell.
Ruihan Yan +5 more
semanticscholar +4 more sources
Transcriptional Regulation by Nrf2
Antioxidants & Redox Signaling, 2017 Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes.
C. Tonelli, I. I. C. Chio, D. Tuveson
semanticscholar +4 more sources
CONSUMPTION OF BROCCOLI SPROUTS INCREASED THE ACTIVITY OF GLUTATHIONE-DEPENDENT ANTIOXIDANT ENZYMES IN MURINE LIVER [PDF]
Biotechnologia Acta, 2023 Aim. The purpose of this work was to investigate effects of the consumption of broccoli sprouts on the activity of antioxidant defense enzymes in the liver of. GPx isoforms.
M.V. IVANOCHKO +3 more
doaj +1 more source
The effect of 12 weeks of aerobic exercise and caloric restriction on Nrf2 protein expression in non-alcoholic fatty liver disease in rats [PDF]
Journal of Shahrekord University of Medical Sciences, 2023 Background and aims: One of the most common causes of liver disease is non-alcoholic fatty liver disease (NAFLD), and its prevalence along with serious clinical problem is a growing. No studies have been conducted on the effect of calorie restriction (CR)
Farzaneh Yadegari, Farhad Rahmani Nia
doaj +1 more source
Antioxidants, 2021 The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation.
Angela Herengt +2 more
openaire +3 more sources
Research advances in the protective effect of sulforaphane against kidney injury and related mechanisms [PDF]
BIO Web of Conferences, 2022 Kidney injury and related diseases have become quite common in recent years, and have attracted more attention. Sulforaphane, a kind of isothiocyanate, is widely distributed in cruciferous plants and it is a common antioxidant. Specifically, sulforaphane
Chang Ruoxi
doaj +1 more source
The NRF2-p97-NRF2 negative feedback loop
Redox Biology, 2023 p97 is a ubiquitin-targeted ATP-dependent segregase that regulates proteostasis, in addition to a variety of other cellular functions. Previously, we demonstrated that p97 negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex, facilitating proteasomal destruction.
Aryatara Shakya +10 more
openaire +3 more sources
Neuroprotective effect of L-deprenyl on the expression level of the Mst1 gene and inhibition of apoptosis in rat-model spinal cord injury [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): After primary tissue damage as a result of spinal cord injury (SCI), there is a period of secondary damage, which includes several cellular and inflammatory biochemical cascades.
Alireza Abdanipour +4 more
doaj +1 more source
Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease
Antioxidants, 2022 Organisms are continually exposed to exogenous and endogenous sources of reactive oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects on the cell.
Vy Ngo, M. Duennwald
semanticscholar +1 more source
Indian Journal of Dermatology, 2021 Background: Acute photodamage is an acute inflammatory reaction of the skin after ultraviolet (UV) irradiation. Many drugs have been successfully used for the treatment and prevention of photodamage.
Li He +6 more
doaj +1 more source