Results 11 to 20 of about 197,106 (353)
NRF2 and the Hallmarks of Cancer [PDF]
Cancer Cell, 2018 SUMMARY The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established ...
Eli Chapman +2 more
exaly +4 more sources
The NRF2-p97-NRF2 negative feedback loop
Redox Biology, 2023 p97 is a ubiquitin-targeted ATP-dependent segregase that regulates proteostasis, in addition to a variety of other cellular functions. Previously, we demonstrated that p97 negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex, facilitating proteasomal destruction.
Aryatara Shakya +10 more
openaire +4 more sources
NRF2, a Superstar of Ferroptosis
Antioxidants, 2023 Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring when there is an imbalance of redox homeostasis in the cell.
Ruihan Yan +5 more
semanticscholar +4 more sources
NRF2, a Transcription Factor for Stress Response and Beyond
International Journal of Molecular Sciences, 2020 Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification.
Feng He, Tao Wen, Xiaoli Ru
exaly +2 more sources
Transcriptional Regulation by Nrf2
Antioxidants & Redox Signaling, 2017 Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes.
C. Tonelli, I. Chio, D. Tuveson
semanticscholar +4 more sources
Natural Products as Modulators of Nrf2 Signaling Pathway in Neuroprotection
International Journal of Molecular Sciences, 2023 Neurodegenerative diseases (NDs) affect the West due to the increase in life expectancy. Nervous cells accumulate oxidative damage, which is one of the factors that triggers and accelerates neurodegeneration.
Ignacio Moratilla-Rivera +3 more
semanticscholar +3 more sources
Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology
Biomolecules, 2020 Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various ...
Shuya Kasai +4 more
doaj +2 more sources
The Effect of high-intensity interval training with coenzyme Q10 supplementation on the Nrf2 and NQO1 in soleus muscle of older rats [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2023 Background and Purpose: Increased oxidative stress is the main characteristic of all types of age-related injuries. Based on the role of physical activity in adaptive responses to oxidative stress and importance of nutritional supplements, the aim of ...
Zahra Noruzi +4 more
doaj +1 more source
Nrf2-Keap1 signaling in oxidative and reductive stress
Biochimica Et Biophysica Acta - Molecular Cell Research, 2018 Alba Minelli +2 more
exaly +2 more sources
Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2<sup>-/-</sup> Mice. [PDF]
Adv Sci (Weinh)The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Wang H +12 more
europepmc +2 more sources