Results 21 to 30 of about 157,133 (211)
AM1638, a GPR40-Full Agonist, Inhibited Palmitate-Induced ROS Production and Endoplasmic Reticulum Stress, Enhancing HUVEC Viability in an NRF2-Dependent Manner [PDF]
Endocrinology and Metabolism, 2023 Background G protein-coupled receptor 40 (GPR40) is a key molecule in diabetes and fatty liver, but its role in endothelial dysfunction remains unclear. Our objective in this study was to determine whether GPR40 agonists protect endothelial cells against
Hwan-Jin Hwang +9 more
doaj +1 more source
Archives of Pharmaceutical Sciences Ain Shams University, 2021 Background: Accumulating evidence proves that cisplatin, a widely used anticancer, causes acute kidney injury (AKI). Sitagliptin (Sita), a dipeptidyl peptidase-4 (DPP4) inhibitor, is a hypoglycemic agent that can promote tissue angiogenesis and cell ...
Mohamed Bassiony +4 more
doaj +1 more source
Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation [PDF]
Free Radical Biology and Medicine, 2017 Although critical in phagocytosis in innate immunity, reactive oxygen species (ROS) collaterally inflict damage to host phagocytes because they indiscriminate targets. Since Nrf2 increases the expression of anti-oxidant enzymes that nullifies ROS, ROS activating Nrf2 is a critical negative regulatory step for countering the deleterious effects of ROS ...
Kyun, Ha Kim +6 more
openaire +2 more sources
Autophagy and liver cancer [PDF]
Clinical and Molecular Hepatology, 2020 Autophagy is a highly conserved catabolic process that degrades cytosolic proteins and organelles via formation of autophagosomes that fuse with lysosomes to form autolysosomes, whereby autophagic cargos are degraded.
Xiaojuan Chao +4 more
doaj +1 more source
NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8
Science Advances, 2023 Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron homeostasis by controlling HERC2 (E3 ubiquitin ligase for NCOA4 and ...
A. Anandhan +16 more
semanticscholar +1 more source
Molecular Basis of the KEAP1-NRF2 Signaling Pathway
Molecules and Cells, 2023 Transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. NRF2 induces expression of detoxification and antioxidant enzymes and suppresses inductions of pro-inflammatory cytokine genes.
Takafumi Suzuki +2 more
semanticscholar +1 more source
The KEAP1-NRF2 pathway: Targets for therapy and role in cancer
Redox Biology, 2023 The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role in various disease pathologies has become well appreciated ...
S. Adinolfi +7 more
semanticscholar +1 more source
Redox Biology, 2023 The protective effects of remote ischemic conditioning (RIC) on acute ischemic stroke have been reported. However, the protective mechanisms of RIC have not been fully elucidated.
Yingying Sun +6 more
semanticscholar +1 more source
Potential of isothiocyanate sulforaphane from broccoli to combat obesity and type 2 diabetes: involvement of NRF2 regulatory pathway [PDF]
The Ukrainian Biochemical JournalBiologically active food components are now considered to be remedies for the prevention and treatment of metabolic disorders of different etiology. The aim of this review was to analyze the current data on the application of isothiocyanate sulforaphane,
M. V. Ivanochko +2 more
doaj +1 more source
Genes & Development, 1999 Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated induction of phase II detoxifying and oxidative stress enzyme genes.
K. Itoh +7 more
semanticscholar +1 more source