Results 21 to 30 of about 179,291 (216)

Role of G{alpha}12 and G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor [PDF]

, 2007
G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress.
Cho, Min Kyung, Choi, Sangdun, Hwang, Jong-Ik, Ki, Sung Hwan, Kim, Sang Geon, Kim, Won Dong, Lee, Chang Ho   +6 more
core   +2 more sources

Nrf2 Modulation in Breast Cancer

Biomedicines, 2022
Reactive oxygen species (ROS) are identified to control the expression and activity of various essential signaling intermediates involved in cellular proliferation, apoptosis, and differentiation. Indeed, ROS represents a double-edged sword in supporting cell survival and death.
Somayyeh Ghareghomi, Mehran Habibi-Rezaei, Marzia Arese, Luciano Saso, Ali Akbar Moosavi-Movahedi   +4 more
openaire   +3 more sources

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival [PDF]

, 2014
Transcription factor NRF2 is an important regulator of oxidative stress. It is involved in cancer progression, and has abnormal constitutive expression in acute myeloid leukaemia (AML).
A Ooi, AG Ooi, BN Chorley, BT Kvinlaug, C Luna, CR Zhao, D J MacEwan, E Estey, E Surdziel, F Kong, G Tan, GM DeNicola, H Wang, H Zhang, I Spinello, J Alam, J Gong, J Winter, JE Anderson, JJ Tsai, JJ Zhao, JN Gong, K M Bowles, K Okamoto, L Zaitseva, L Zaitseva, M Bousquet, M Bousquet, MB Sporn, MY Murray, N Hanada, N M Shah, P Moi, PA Konstantinopoulos, R Garzon, R Garzon, R Garzon, R Venugopal, S A Rushworth, S Liu, SA Rushworth, SA Rushworth, SA Rushworth, TWP Devling, W Blum, Y Wang, YR Kim   +46 more
core   +1 more source

Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation [PDF]

Free Radical Biology and Medicine, 2017
Although critical in phagocytosis in innate immunity, reactive oxygen species (ROS) collaterally inflict damage to host phagocytes because they indiscriminate targets. Since Nrf2 increases the expression of anti-oxidant enzymes that nullifies ROS, ROS activating Nrf2 is a critical negative regulatory step for countering the deleterious effects of ROS ...
Kyun, Ha Kim, Ruxana T, Sadikot, Ji, Yeon Lee, Han-Sol, Jeong, Yu-Kyoung, Oh, Timothy S, Blackwell, Myungsoo, Joo   +6 more
openaire   +2 more sources

Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes [PDF]

Biochemical Pharmacology, 2009
Oleanolic acid is a plant-derived triterpenoid, which protects against various hepatotoxicants in rodents. In order to determine whether oleanolic acid activates nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor known to induce various antioxidant and cytoprotective genes, wild-type and Nrf2-null mice were treated with ...
Scott A, Reisman, Lauren M, Aleksunes, Curtis D, Klaassen   +2 more
openaire   +2 more sources

Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]

, 2019
Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y., Kankia, Ibrahim H., Langdon, Simon P., Paramasivan, Poornima   +3 more
core   +3 more sources

Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan. [PDF]

, 2020
Increased resistance to environmental stress at the cellular level is correlated with the longevity of long-lived mutants and wild-animal species. Moreover, in experimental organisms, screens for increased stress resistance have yielded mutants that are ...
Ang, Kenny Kean-Hooi, Arkin, Michelle, Cregg, James, Kenyon, Cynthia, Zhai, Yuying, Zhang, Peichuan   +5 more
core   +2 more sources

In vivo delivery of transcription factors with multifunctional oligonucleotides. [PDF]

, 2015
Therapeutics based on transcription factors have the potential to revolutionize medicine but have had limited clinical success as a consequence of delivery problems. The delivery of transcription factors is challenging because it requires the development
Aran, Kiana, Feng, Xuli, Kim, Hyun, Lee, Kunwoo, Lingampalli, Nithya, Lo Sterzo, Carlo, Murthy, Niren, Rafi, Mohammad, Tang, Richard, Wang, Xiaojian   +9 more
core   +3 more sources

NRF2-targeted therapeutics: New targets and modes of NRF2 regulation [PDF]

Current Opinion in Toxicology, 2016
Pharmacological activation of the transcription factor nuclear factor-erythroid derived 2-like 2 (NRF2), the key regulator of the cellular antioxidant response, has been recognized as a feasible strategy to reduce oxidative/electrophilic stress and prevent carcinogenesis or other chronic illnesses, such as diabetes and chronic kidney disease.
Montserrat, Rojo de la Vega, Matthew, Dodson, Eli, Chapman, Donna D, Zhang   +3 more
openaire   +2 more sources

Compound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses

Pharmaceutical Biology, 2021
Context Previous studies indicate that compound Danshen Dripping Pill (CDDP) improves the adaptation to high-altitude exposure. However, its mechanism of action is not clear.
Yunhui Hu, Jia Sun, Tongxing Wang, Hairong Wang, Chunlai Zhao, Wenjia Wang, Kaijing Yan, Xijun Yan, He Sun   +8 more
doaj   +1 more source