Results 21 to 30 of about 197,106 (353)
Antioxidants, 2021 The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation.
Angela Herengt +2 more
openaire +3 more sources
Journal of Tropical Life Science, 2023 This research aims to analyze the effect of unripe sapodilla fruit extract on endogenous antioxidant expression in T1DM BALB/c mice and its free radical scavenging activity.
Muhaimin Rifa'i +6 more
doaj +1 more source
The importance of polymorphisms of regulatory and catalytic antioxidant proteins in chronic kidney disease [PDF]
Medicinski Podmladak, 2021 Both excessive production of reactive oxygen species (ROS) and impaired antioxidant function are found in patients with chronic kidney disease (CKD).
Jerotić Đurđa +2 more
doaj +1 more source
Understanding the molecular basis of vitiligo - a systematic review
Journal of Education, Health and Sport, 2023 Introduction: Vitiligo is a systemic, chronic, hypopigmented dermatosis of unclear background. The disease is characterized by the selective loss or dysfunction of melanocytes.
Magdalena Osuch +6 more
doaj +1 more source
Ginger (Zingiber officinale roscoe) extract could upregulate the renal expression of NRF2 and TNFα and prevents ethanol-induced toxicity in rat kidney [PDF]
Avicenna Journal of Phytomedicine, 2021 Objective: Ginger has protective effects on the kidney, however the molecular mechanism of this effect has not yet been fully elucidated. Therefore, this work studied molecular mechanisms of ginger effects on ethanol-induced kidney injury.
Rozita Fathi +3 more
doaj +1 more source
Pancreatic β-cell protective effect of novel GABA derivatives in rats with type 2 diabetes
Research Results in Pharmacology, 2023 Introduction: Gamma-aminobutyric acid (GABA) and GABAergic compounds emerged as potential therapeutic agents for diabetes mellitus and its complications.
Ivan N. Tyurenkov +9 more
doaj +1 more source
Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease
Antioxidants, 2022 Organisms are continually exposed to exogenous and endogenous sources of reactive oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects on the cell.
Vy Ngo, M. Duennwald
semanticscholar +1 more source
Journal of Veterinary Research, 2023 Penconazole (PEN) is a widely applied triazole fungicide. This study sought to define the efficacy of N-acetyl-l-cysteine (NAC) in mitigating PEN-triggered hepatorenal toxicity in rats.
Morgan Ashraf M. +10 more
doaj +1 more source
Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation [PDF]
Free Radical Biology and Medicine, 2017 Although critical in phagocytosis in innate immunity, reactive oxygen species (ROS) collaterally inflict damage to host phagocytes because they indiscriminate targets. Since Nrf2 increases the expression of anti-oxidant enzymes that nullifies ROS, ROS activating Nrf2 is a critical negative regulatory step for countering the deleterious effects of ROS ...
Kyun, Ha Kim +6 more
openaire +2 more sources
Regulation of Nrf2—an update [PDF]
Free Radical Biology and Medicine, 2014 Nrf2:INrf2 (Keap1) are cellular sensors of oxidative and electrophilic stress. Nrf2 is a nuclear factor that controls the expression and coordinated induction of a battery of genes that encode detoxifying enzymes, drug transporters, antiapoptotic proteins, and proteasomes.
Suryakant K, Niture +2 more
openaire +2 more sources