Results 21 to 30 of about 108,098 (261)

Nrf2 Modulation in Breast Cancer

Biomedicines, 2022
Reactive oxygen species (ROS) are identified to control the expression and activity of various essential signaling intermediates involved in cellular proliferation, apoptosis, and differentiation. Indeed, ROS represents a double-edged sword in supporting cell survival and death.
Somayyeh Ghareghomi, Mehran Habibi-Rezaei, Marzia Arese, Luciano Saso, Ali Akbar Moosavi-Movahedi   +4 more
openaire   +3 more sources

Apigenin Alleviates Allodynia and Hyperalgesia in a Mouse Model of Chemotherapy-Induced Peripheral Neuropathy via Regulating Microglia Activation and Polarization

Journal of Integrative Neuroscience, 2023
Background: Apigenin has been reported to exhibit anti-inflammatory and anti-oxidative activities. This study aimed to investigate the protective role of Apigenin on chemotherapy-induced peripheral neuropathy (CIPN).
Wenji Xie, Wenqin Xie, Changcheng Jiang, Zhenming Kang, Naizhen Liu   +4 more
doaj   +1 more source

NRF2-targeted therapeutics: New targets and modes of NRF2 regulation [PDF]

Current Opinion in Toxicology, 2016
Pharmacological activation of the transcription factor nuclear factor-erythroid derived 2-like 2 (NRF2), the key regulator of the cellular antioxidant response, has been recognized as a feasible strategy to reduce oxidative/electrophilic stress and prevent carcinogenesis or other chronic illnesses, such as diabetes and chronic kidney disease.
Montserrat, Rojo de la Vega, Matthew, Dodson, Eli, Chapman, Donna D, Zhang   +3 more
openaire   +2 more sources

Nrf1 acts as a highly-conserved determinon for maintaining robust redox homeostasis in the eco-evo-devo process of life histories

Cell Stress
Differential and even opposing functions of two major antioxidant transcription factors Nrf1 and Nrf2 (encoded by Nfe2l1 and Nfe2l2, respectively) are determined by distinctions in their tempospatial positioning, topological repartitioning, proteolytic ...
Yiguo Zhang, Xi Chen, Meng Wang, Yuping Zhu, Wei Shi, Chao Li, Zhengwen Zhang, Hiroaki Taniguchi, Ping Ao   +8 more
doaj   +1 more source

Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson’s disease by promoting Nrf2/NQO-1 pathway

Translational Neuroscience, 2022
Parkinson’s disease (PD) is a common neurodegenerative disease that severely affects the quality of life of patients. There is no specific drug for PD up to now.
Huang Lijuan, Han Yan, Zhou Qingmin, Sun Zhihao, Yan Jianhui   +4 more
doaj   +1 more source

Nrf2 Inhibits the Progression of Parkinson’s Disease by Upregulating AABR07032261.5 to Repress Pyroptosis

Journal of Inflammation Research, 2022
Yunxiao Zhong,1,* Xiaodong Cai,2,* Li Ding,3,* Jinchi Liao,1 Xu Liu,1 Yiying Huang,1 Xiaohong Chen,1 Ling Long1 1Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, 510600, People’s
Zhong Y, Cai X, Ding L, Liao J, Liu X, Huang Y, Chen X, Long L   +7 more
doaj  

Nrf2 in liver toxicology

Archives of Pharmacal Research, 2019
Liver plays essential roles in the metabolism of many endogenous chemicals and exogenous toxicants. Mechanistic studies in liver have been at the forefront of efforts to probe the roles of bioactivation and detoxication of environmental toxins and toxicants in hepatotoxicity.
Keiko Taguchi, Thomas W. Kensler
openaire   +3 more sources

Chinese Herbs and Repurposing Old Drugs as Therapeutic Agents in the Regulation of Oxidative Stress and Inflammation in Pulmonary Diseases

Journal of Inflammation Research, 2021
Chien-Chung Yang,1,2 Chuen-Mao Yang3– 5 1Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital at Tao-Yuan, Kwei-San, Tao-Yuan, 33302, Taiwan; 2School of Traditional Chinese Medicine, College of Medicine, Chang Gung University ...
Yang CC, Yang CM
doaj  

NRF2 regulation in the developing brain cortex from rat offspring exposed to intrauterine and early postnatal zinc deficits

Redox Experimental Medicine
Objective: Transcription factor NRF2, master regulator of the antioxidant response, is also involved in brain development. This paper investigated the role of NRF2 in developmental zinc deficiency-associated alterations in rat brain cortex: i ...
Wei Zhu, Patricia I Oteiza
doaj   +1 more source

Nrf2 and the Nrf2-Interacting Network in Respiratory Inflammation and Diseases [PDF]

, 2020
Atmospheric pollutants and cigarette smoke influence the human respiratory system and induce airway inflammation, injury, and pathogenesis. Activation of the NF-E2-related factor 2 (Nrf2) transcription factor and downstream antioxidant response element (ARE)-mediated transcriptions play a central role in protecting respiratory cells against reactive ...
Carlson, Jennifer, Price, Lindsey, Deng, Huai   +2 more
openaire   +1 more source