Results 71 to 80 of about 157,133 (211)

Microenvironmental Activation of Nrf2 Restricts the Progression of Nrf2-Activated Malignant Tumors [PDF]

Cancer Research, 2020
Abstract The transcription factor Nrf2 activates transcription of cytoprotective genes during oxidative and electrophilic insults. Nrf2 activity is regulated by Keap1 in a stress-dependent manner in normal cells, and somatic loss-of-function mutations of Keap1 are known to induce constitutive ...
Makiko Hayashi, Ayumi Kuga, Mikiko Suzuki, Harit Panda, Hiroshi Kitamura, Hozumi Motohashi, Masayuki Yamamoto   +6 more
openaire   +2 more sources

Protective effect and mechanism of alpha-lipoic acid on lead-induced Sertoli cell damage in rooster testes

Asian Pacific Journal of Reproduction
Objective: To investigate the protective effect of alpha-lipoic acid on lead-induced Sertoli cell injury and its potential molecular mechanisms using primary Sertoli cells from rooster testes. Methods: Primary Sertoli cells from 6-week-old rooster testes
Junrong Li, Shanli Zhu, Nanwei Ye, Fangxiong Shi   +3 more
doaj   +1 more source

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Molecules, 2019
There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the isothiocyanate sulforaphane.
Yoko Yagishita, Jed W. Fahey, Albena T. Dinkova-Kostova, Thomas W. Kensler   +3 more
doaj   +1 more source

Nrf2and Cardiovascular Defense [PDF]

Oxidative Medicine and Cellular Longevity, 2013
The cardiovascular system is susceptible to a group of diseases that are responsible for a larger proportion of morbidity and mortality than any other disease. Many cardiovascular diseases are associated with a failure of defenses against oxidative stress-induced cellular damage and/or death, leading to organ dysfunction.
openaire   +2 more sources

Features of the free radical status of the follicular fluid of mares in the process of folliculogenesis

Siberian Journal of Life Sciences and Agriculture
Background.  The maturation of germ cells is a complex and multilevel process. To increase the effectiveness of assisted reproductive technologies in horses, a detailed study of the mechanisms of regulation of folliculogenesis is necessary. Purpose. A
Valery V. Kalashnikov, Lyudmila F. Lebedeva, Olga V. Bakovetskaya, Anna A. Terekhina, Elena V. Solodova, Yulia V. Abalenikhina, Aleksey V. Shchulkin   +6 more
doaj   +1 more source

VA inhibits LPS-induced oxidative stress via modulating Nrf2/NF-κB-signalling pathways in bovine mammary epithelial cells

Italian Journal of Animal Science, 2019
The current study was conducted to examine the pre-protection effects of vitamin A (VA) on lipopolysaccharide (LPS)-induced oxidative damage in bovine mammary epithelial cells (BMECs) and to explore the antioxidant mechanisms of VA via nuclear factor ...
Huiyu Shi, Xiaoyu Guo, Sumei Yan, Yongmei Guo, Binlin Shi, Yanli Zhao   +5 more
doaj   +1 more source

Biomarkers of NRF2 signalling: Current status and future challenges

Redox Biology
The cytoprotective transcription factor NRF2 regulates the expression of several hundred genes in mammalian cells and is a promising therapeutic target in a number of diseases associated with oxidative stress and inflammation.
C. Morgenstern, I. Lastres-Becker, B. C. Demirdöğen, V. M. Costa, A. Daiber, R. Foresti, R. Motterlini, Sibel Kalyoncu, B. I. Arioz, Şermin Genç, Monika Jakubowska, I. Trougakos, A. Piechota-Polańczyk, Michel-Edwar Mickael, Marlene Santos, T. Kensler, Antonio Cuadrado, I. Copple   +17 more
semanticscholar   +1 more source

Elucidating the Role of Nrf2 Signaling Pathway in Mycoplasma Infections

Frontiers in Bioscience-Landmark
Mycoplasmas are the smallest cell-wall-less self-replicating prokaryotes. Mycoplasma species can be found within and outside cells as “silent parasites” that live intracellularly and as membrane surface parasites.
Sarmistha Saha, Nadezhda Sachivkina, Olga Kuznetsova, Ekaterina Neborak, Natallia Zhabo   +4 more
doaj   +1 more source

Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes [PDF]

Biochemical Pharmacology, 2009
Oleanolic acid is a plant-derived triterpenoid, which protects against various hepatotoxicants in rodents. In order to determine whether oleanolic acid activates nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor known to induce various antioxidant and cytoprotective genes, wild-type and Nrf2-null mice were treated with ...
Scott A, Reisman, Lauren M, Aleksunes, Curtis D, Klaassen   +2 more
openaire   +2 more sources

1,3,4, Oxadiazole Compound A3 Provides Robust Protection Against PTZ-Induced Neuroinflammation and Oxidative Stress by Regulating Nrf2-Pathway [Retraction]

Journal of Inflammation Research, 2022
Alvi AM, Shah FA, Muhammad AJ, Feng J, Li S. J Inflamm Res. 2021;14:7393–7409. The Editor and Publisher of Journal of Inflammation Research wish to retract the published article.
Alvi AM, Shah FA, Muhammad AJ, Feng J, Li S   +4 more
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