Results 71 to 80 of about 197,106 (353)

NRF2-targeted therapeutics: New targets and modes of NRF2 regulation [PDF]

Current Opinion in Toxicology, 2016
Pharmacological activation of the transcription factor nuclear factor-erythroid derived 2-like 2 (NRF2), the key regulator of the cellular antioxidant response, has been recognized as a feasible strategy to reduce oxidative/electrophilic stress and prevent carcinogenesis or other chronic illnesses, such as diabetes and chronic kidney disease.
Montserrat, Rojo de la Vega, Matthew, Dodson, Eli, Chapman, Donna D, Zhang   +3 more
openaire   +2 more sources

Nrf2 Modulation in Breast Cancer

Biomedicines, 2022
Reactive oxygen species (ROS) are identified to control the expression and activity of various essential signaling intermediates involved in cellular proliferation, apoptosis, and differentiation. Indeed, ROS represents a double-edged sword in supporting cell survival and death.
Somayyeh Ghareghomi, Mehran Habibi-Rezaei, Marzia Arese, Luciano Saso, Ali Akbar Moosavi-Movahedi   +4 more
openaire   +3 more sources

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Nature, 2018
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood.
E. Mills, D. Ryan, H. Prag, D. Dikovskaya, D. Menon, Z. Zaslona, Mark P. Jedrychowski, Ana S. H. Costa, M. Higgins, E. Hams, John Szpyt, M. Runtsch, M. King, J. McGouran, R. Fischer, B. Kessler, A. F. Mcgettrick, M. Hughes, R. Carroll, Lee M. Booty, Elena V. Knatko, P. Meakin, M. Ashford, Louise K Modis, Gino Brunori, D. Sévin, P. Fallon, S. Caldwell, Edmund R. S. Kunji, E. Chouchani, C. Frezza, A. Dinkova-Kostova, R. Hartley, M. Murphy, L. O'Neill   +34 more
semanticscholar   +1 more source

Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction [PDF]

, 2010
Abnormal lung inflammation and oxidant burden are associated with a significant reduction in histone deacetylase 2 (HDAC2) abundance and steroid resistance.
Adenuga, David, Hongwei Yao, Sangwoon Chung, Isaac K. Sundar, David Adenuga, Yao, Hongwei, Caito, Samuel, Jae-Woong Hwang, Sundar, Isaac K, Hwang, Jae-woong, Rahman, Irfan, Irfan Rahman, Chung, Sangwoon, Samuel Caito   +13 more
core   +1 more source

Aerobic Exercise Ameliorates Liver Injury in Db/Db Mice by Attenuating Oxidative Stress, Apoptosis and Inflammation Through the Nrf2 and JAK2/STAT3 Signalling Pathways

Journal of Inflammation Research, 2023
Meiyan Sun,1,2,* Xiaoyong Zhao,2,* Xingyue Li,2 Chunling Wang,2 Lili Lin,3 Kaifang Wang,2 Yingui Sun,2 Wei Ye,3 Haiyan Li,3 Ye Zhang,1 Chaolu Huang2,4 1Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of ...
Sun M, Zhao X, Li X, Wang C, Lin L, Wang K, Sun Y, Ye W, Li H, Zhang Y, Huang C   +10 more
doaj  

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

Cellular and Molecular Life Sciences, 2016
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a ...
A. Loboda, M. Damulewicz, E. Pyza, A. Józkowicz, J. Dulak   +4 more
semanticscholar   +1 more source

Ginseng Saponin Rb1 Attenuates Cigarette Smoke Exposure-Induced Inflammation, Apoptosis and Oxidative Stress via Activating Nrf2 and Inhibiting NF-κB Signaling Pathways

International Journal of COPD, 2023
Zhizheng Li,1 Li Li,1 Xiaohui Lv,1 Yingqian Hu,1 Kun Cui2 1Department of Respiratory and Critical Care Medicine, Tangshan Gongren Hospital, Tangshan, People’s Republic of China; 2Respiratory Medicine, Tangshan Gongren Hospital, Tangshan, People’s ...
Li Z, Li L, Lv X, Hu Y, Cui K
doaj  

Nrf2 and the Nrf2-Interacting Network in Respiratory Inflammation and Diseases [PDF]

, 2020
Atmospheric pollutants and cigarette smoke influence the human respiratory system and induce airway inflammation, injury, and pathogenesis. Activation of the NF-E2-related factor 2 (Nrf2) transcription factor and downstream antioxidant response element (ARE)-mediated transcriptions play a central role in protecting respiratory cells against reactive ...
Carlson, Jennifer, Price, Lindsey, Deng, Huai   +2 more
openaire   +1 more source

Environmental toxicity, redox signaling and lung inflammation:the role of glutathione [PDF]

, 2009
Glutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress.
Saibal K. Biswas, Biswas, Saibal K, Rahman, Irfan, Irfan Rahman   +3 more
core   +1 more source

Leukemia Inhibitory Factor Attenuates Hypoxic–Ischemic White Matter Injury via NLRP3 Inflammasome Activity Suppressing Through the Nrf2/HO-1 Pathway

Frontiers in Bioscience-Landmark
Background: Inhibiting neuroinflammatory damage is an effective strategy for treating preterm white matter injury (PWMI). Leukemia inhibitory factor (LIF) can ameliorate (HI) induced white matter injury; however, the neuroprotective ...
Liang Huo, Xueyan Liu, Hua Wang
doaj   +1 more source