Results 81 to 90 of about 157,133 (211)
Is a Meal without Wine Good for Health?
Diseases, 2018 Hippocrates, the father of medicine, had said: “Wine is a thing wonderfully appropriate to man if, in health as in disease, it is administered with appropriate and just measure according to the individual constitution.„ Wine has always ...
Jean-Pierre Rifler
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Polymorphisms of NRF2 and NRF2 target genes in urinary bladder cancer patients [PDF]
Journal of Cancer Research and Clinical Oncology, 2014 NRF2 transcription factor is involved in modulation of various antioxidant and metabolic genes and, therefore, may modulate anti-carcinogenic potential. Association between polymorphisms of NRF2 and five NRF2-regulated genes and urinary bladder cancer (BC) risk was analyzed.The study group included 244 BC patients, while the control group comprised 365
Reszka, Edyta +8 more
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How to deal with frenemy NRF2: Targeting NRF2 for chemoprevention and cancer therapy
Journal of Food and Drug Analysis, 2023 Induction of antioxidant proteins and phase 2 detoxifying enzymes that neutralize reactive electrophiles are important mechanisms for protection against carcinogenesis. Normal cells provide multifaceted pathways to tightly control NF-E2-related factor 2 (NRF2)-mediated gene expression in response to an assault by a range of endogenous and exogenous ...
Tang, Ya-Chu +6 more
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Marine Drugs, 2019 Fucoxanthin (Fx) is a natural extract from marine seaweed that has strong antioxidant activity and a variety of other bioactive effects. This study elucidated the protective mechanism of Fx on alcoholic liver injury.
Jiawen Zheng +6 more
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The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2.
Cell Reports, 2023 The redox regulator NRF2 becomes activated upon oxidative and electrophilic stress and orchestrates a response program associated with redox regulation, metabolism, tumor therapy resistance, and immune suppression.
J. Kreß +9 more
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Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling [PDF]
The EMBO Journal, 2006 Keap1 is a BTB-Kelch substrate adaptor protein that regulates steady-state levels of Nrf2, a bZIP transcription factor, in response to oxidative stress. We have determined the structure of the Kelch domain of Keap1 bound to a 16-mer peptide from Nrf2 containing a highly conserved DxETGE motif.
Shih-Ching, Lo +4 more
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The Nrf2-HO-1 system and inflammaging
Frontiers in ImmunologyNrf2 is a master transcriptional regulator of a number of genes involved in the adaptive response to oxidative stress. Among the genes upregulated by Nrf2, heme oxygenase-1 (HO-1) has received significant attention, given that the products of HO-1 ...
Sinead A. O'Rourke +2 more
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Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers
Frontiers in Oncology, 2023 Cancer is a borderless global health challenge that continues to threaten human health. Studies have found that oxidative stress (OS) is often associated with the etiology of many diseases, especially the aging process and cancer.
Li Lin +10 more
semanticscholar +1 more source
Animals, 2020 Intrauterine growth retardation (IUGR) exhibits programming consequences and may induce oxidative stress in growing animals and humans. This study was conducted to investigate the hypothesis that dietary curcumin may protect growing pigs from IUGR ...
Ligen Zhang +7 more
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Effect of Low-Level Laser Therapy on the Nrf2/Keap1 Pathway in NMRI Mice with Testicular Torsion [PDF]
Journal of Mazandaran University of Medical SciencesBackground and purpose: Testicular torsion (TT) is a urological emergency characterized by twisting of the spermatic cord, which reduces blood flow and leads to testicular ischemia.
Mohammad Bayat +4 more
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