Results 81 to 90 of about 197,106 (353)
Cell Death DiscoveryNuclear factor erythroid 2-related factor 2 (NRF2) is a key transcription factor involved in regulating cellular antioxidant defense and detoxification mechanisms.
Xinyi Yang +12 more
semanticscholar +1 more source
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.
Physiological Reviews, 2018 The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system forms the major node of cellular and organismal defense against oxidative and electrophilic stresses of both exogenous and endogenous origins.
M. Yamamoto +2 more
semanticscholar +1 more source
Nrf2 signalling and autophagy are involved in diabetes mellitus-induced defects in the development of mouse placenta [PDF]
Open Biology, 2016 It is widely accepted that diabetes mellitus impairs placental development, but the mechanism by which the disease operates to impair development remains controversial.
Mei-yao He +10 more
doaj +1 more source
Molecules, 2020 We investigated the potential ability of quercetin to protect against lipopolysaccharide (LPS)-induced intestinal oxidative stress in broiler chickens and the potential role of the Nrf2 (nuclear factor erythroid 2-related factor 2) signaling pathway. One-
Lei Sun +5 more
doaj +1 more source
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022 The present study aimed to investigate whether dexmedetomidine (Dex) exerts cardioprotection effect through inhibiting ferroptosis. Myocardial ischemia/reperfusion injury (MIRI) was induced in Sprague-Dawley rats in Langendorff preparation.
Zhuoran Wang +8 more
semanticscholar +1 more source
Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia. [PDF]
, 2014 Inherited deficiency in the mitochondrial protein frataxin (FXN) causes the rare disease Friedreich's ataxia (FA), for which there is no successful treatment. We identified a redox deficiency in FA cells and used this to model the disease.
Perlman, SL +17 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance
Cells, 2020 Epithelial to mesenchymal transition (EMT) contributes to tumor progression, cancer cell invasion, and therapy resistance. EMT is regulated by transcription factors such as the protein products of the SNAI gene family, which inhibits the expression of ...
József Dudás +4 more
doaj +1 more source
The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress*
Journal of Biological Chemistry, 2009 A major mechanism in the cellular defense against oxidative or electrophilic stress is activation of the Nrf2-antioxidant response element signaling pathway, which controls the expression of genes whose protein products are involved in the detoxication ...
Truyen Nguyen, P. Nioi, C. B. Pickett
semanticscholar +1 more source
The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging
Oxidative Medicine and Cellular Longevity, 2021 Oxidative stress, a term that describes the imbalance between oxidants and antioxidants, leads to the disruption of redox signals and causes molecular damage.
Chao Yu, Jian-Hui Xiao
semanticscholar +1 more source