Results 91 to 100 of about 197,106 (353)
NRF2 molecule of the month [PDF]
Bioinformation, 2012 NRF2 – nuclear factor erythroid 2-related factor 2 is also known as GA binding protein transcription factor, alpha subunit 60kDa- GABPA [1, 2]. A recent literature review suggests that NRF2 has complex regulatory roles in cancer. NRF2 is a transcription factor and is upregulated by oncogenes.
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer
Experimental and Molecular MedicineOxygen is crucial for life and acts as the final electron acceptor in mitochondrial energy production. Cells adapt to varying oxygen levels through intricate response systems. Hypoxia-inducible factors (HIFs), including HIF-1α and HIF-2α, orchestrate the
Taegeun Bae, S. Hallis, Mi-Kyoung Kwak
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Archives of Pharmacal Research, 2019 Liver plays essential roles in the metabolism of many endogenous chemicals and exogenous toxicants. Mechanistic studies in liver have been at the forefront of efforts to probe the roles of bioactivation and detoxication of environmental toxins and toxicants in hepatotoxicity.
Keiko Taguchi, Thomas W. Kensler
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Nrf2 Regulates CHI3L1 to Suppress Inflammation and Improve Post-Traumatic Osteoarthritis
Journal of Inflammation Research, 2021 Yang Song,1,2 Dake Hao,3 Huan Jiang,4 Mingguang Huang,2 Qingjun Du,2 Yi Lin,2 Fei Liu,1 Bin Chen1 1Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s Republic ...
Song Y +7 more
doaj
Nrf2/Keap1/ARE signaling: Towards specific regulation
Life Science, 2021 The Nrf2 transcription factor governs the expression of hundreds genes involved in cell defense against oxidative stress, the hallmark of numerous diseases such as neurodegenerative, cardiovascular, some viral pathologies, diabetes and others.
A. V. Ulasov +3 more
semanticscholar +1 more source
Nrf2: not “lost in translation”
Aging, 2016 Multiple myeloma (MM) is a clonal plasma cell malignancy which is frequently diagnosed in patients over 65 years of age. Because of an aging population, the incidence of MM has increased nearly 1 percent annually since 1975 and it is anticipated that the number of cases will nearly double by 2034 [1].
Hawley, Robert G., Riz, Irene
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Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia
, 2017 Hypoxia leads to reactive oxygen species (ROS) imbalance, which is proposed to associate with drug resistance and oncogenesis. Inhibition of enzymes of antioxidant balancing system in tumor cells was shown to reduce chemoresistance under hypoxia. However,
Syu, Jhih-Pu;Chi, Jen-Tsan;Kung, Hsiu-Ni +1 more
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Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
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