Results 91 to 100 of about 157,133 (211)
The role of genes and myokines of developing sarcopenia: A review [PDF]
Consilium MedicumSarcopenia is associated with progressive generalized skeletal muscle weakness, persistent decline in muscle strength, function, and quality of life in the elderly population. The presence of sarcopenia worsens the prognosis of older patients.
Farida V. Valeeva +2 more
doaj +1 more source
Nature Communications, 2020 Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 are urgently required.
D. Olagnier +37 more
semanticscholar +1 more source
Drug Design, Development and Therapy, 2020 Feng Gao,1 Shanyong Zhang2 1Department of Orthopedics, The Second Hospital of Jilin University, Changchun City, Jilin Province 130041, People’s Republic of China; 2Department of Spine Surgery, The Second Hospital of Jilin University, Changchun City,
Gao F, Zhang S
doaj
Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology
Biomolecules, 2020 Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various ...
S. Kasai +4 more
semanticscholar +1 more source
Voluntary exercise improves pulmonary inflammation through NF-κB and Nrf-2 in type 2 diabetic male rats [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): This study aimed to evaluate the effects of voluntary exercise as an anti-inflammatory intervention on the pulmonary levels of inflammatory cytokines in type 2 diabetic male rats.Materials and Methods: Twenty-eight male Wistar rats were ...
Seyed Zanyar Athari +6 more
doaj +1 more source
Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction
Medicinal Chemistry Research, 2020 Activation of the transcription factor Nrf2 via the Keap1-Nrf2-ARE signaling system regulates the transcription and subsequent expression of cellular cytoprotective proteins and plays a crucial role in preventing pathological conditions exacerbated by the overproduction of oxidative stress.
Sumi Lee, Longqin Hu
openaire +3 more sources
NRF2 addiction in cancer cells [PDF]
Cancer Science, 2018 The Kelch‐like ECH‐associated protein 1/nuclear factor erythroid‐derived 2‐like 2 (KEAP1‐NRF2) system is a pivotal defense mechanism against oxidative and electrophilic stress. Although transient NRF2 activation in response to stress is beneficial for health, persistent NRF2 activation in cancer cells has deleterious effects on cancer‐bearing hosts by ...
Hiroshi Kitamura, Hozumi Motohashi
openaire +2 more sources
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
Nature Communications, 2016 Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic stress response and also represses inflammation. However, the mechanisms how Nrf2 alleviates inflammation are still unclear.
E. Kobayashi +10 more
semanticscholar +1 more source
Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases
Frontiers in Neuroscience, 2020 Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which is inhibited by iron chelators and lipophilic antioxidants. In addition to
Xiaohua Song, Dingxin Long
semanticscholar +1 more source
Aging, 2020 Acute lung injury (ALI) is a syndrome associated with a high mortality rate. Nrf2 is a key regulator of intracellular oxidation homeostasis that plays a pivotal role in controlling lipid peroxidation, which is closely related to the process of ...
H. Dong +6 more
semanticscholar +1 more source