Results 111 to 120 of about 197,106 (353)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Protective Effect of Astaxanthin on Ochratoxin A-Induced Kidney Injury to Mice by Regulating Oxidative Stress-Related NRF2/KEAP1 Pathway

Molecules, 2020
The present study aimed to investigate the effects of astaxanthin (ASX) on ochratoxin A (OTA)-induced renal oxidative stress and its mechanism of action.
Lin Li, Yueli Chen, Danyang Jiao, Shuhua Yang, Lin Li, Peng Li   +5 more
doaj   +1 more source

Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers

Frontiers in Oncology, 2023
Cancer is a borderless global health challenge that continues to threaten human health. Studies have found that oxidative stress (OS) is often associated with the etiology of many diseases, especially the aging process and cancer.
Li Lin, Qing Wu, Feifei Lu, Jiaming Lei, Yan-Hong Zhou, Yi-Fei Liu, Ni Zhu, You Yu, Zhifeng Ning, Tonghui She, Mei-Chun Hu   +10 more
semanticscholar   +1 more source

The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and β-TrCP-NRF2 interactions in cancer chemoresistance

, 2022
Drug resistance is one of the biggest challenges in cancer treatment and limits the potential to cure patients. In many tumors, sustained activation of the protein NRF2 makes tumor cells resistant to chemo- and radiotherapy.
Srivastava, Rohini, Fernández-Ginés, Raquel, Wells, Geoff, Cuadrado, Antonio, Wells, Geoffrey, Encinar, José Antonio   +5 more
core   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2

Drug Design, Development and Therapy, 2020
Xiaojing Shi, Guizhou Tao, Lili Ji, Ge Tian Department of Cardiology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People’s Republic of ChinaCorrespondence: Xiaojing ShiDepartment of Cardiology, The First Affiliated ...
Shi X, Tao G, Ji L, Tian G
doaj  

The Age-Specific Features and Clinical Significance of NRF2 and MAPK10 Expression in HCC Patients

International Journal of General Medicine, 2022
Manar Atyah,1,* Chenhao Zhou,1,* Qiang Zhou,1 Wanyong Chen,1 Jialei Weng,1 Pengcheng Wang,1 Yi Shi,2 Qiongzhu Dong,3,4 Ning Ren1,3 1Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and ...
Atyah M, Zhou C, Zhou Q, Chen W, Weng J, Wang P, Shi Y, Dong Q, Ren N   +8 more
doaj  

Biomarkers of NRF2 signalling: Current status and future challenges

Redox Biology
The cytoprotective transcription factor NRF2 regulates the expression of several hundred genes in mammalian cells and is a promising therapeutic target in a number of diseases associated with oxidative stress and inflammation.
C. Morgenstern, I. Lastres-Becker, B. C. Demirdöğen, V. M. Costa, A. Daiber, R. Foresti, R. Motterlini, Sibel Kalyoncu, B. I. Arioz, Şermin Genç, Monika Jakubowska, I. Trougakos, A. Piechota-Polańczyk, Michel-Edwar Mickael, Marlene Santos, T. Kensler, Antonio Cuadrado, I. Copple   +17 more
semanticscholar   +1 more source

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases. [PDF]

, 2013
Cullin-RING ligases are multisubunit E3 ubiquitin ligases that recruit substrate-specific adaptors to catalyze protein ubiquitylation. Cul3-based Cullin-RING ligases are uniquely associated with BTB adaptors that incorporate homodimerization, Cul3 ...
Bullock, AN, Canning, P, Marsden, BD, Gileadi, Opher, Gileadi, O, Krojer, Tobias, Pike, AC, von Delft, F, Hojzan, V, Thangaratnarajah, C, Murray, James W., Cooper, CD, Keates, Tracy, Thangaratnarajah, Chancievan, Bullock, Alex N., Knapp, Stefan, Marsden, Brian D., Knapp, S, Hojzan, Viktorija, Murray, JW, von Delft, Frank, Chaikuad, A, Keates, T, Ayinampudi, Vikram, Ayinampudi, V, Pike, Ashley C.W., Chaikuad, Apirat, Krojer, T, Canning, Peter, Cooper, Christopher D.O., Bullock, Alexander   +30 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source