NF-E2-related factor 2 over-expression in mesenchymal stem cells to improve cellular cardiomyoplasty [PDF]
Electronic Physician, 2014 Myocardial infarction (MI) is the leading cause of death worldwide. Various therapeutic strategies have been introduced for MI treatment. In recent years, interest in utilizing mesenchymal stem cells (MSCs) for MI therapy has increased.
Mohammad Mohammadzadeh-Vardin +1 more
doaj +4 more sources
NF-E2-Related Factor 2 (Nrf2) Ameliorates Radiation-Induced Skin Injury [PDF]
Frontiers in Oncology, 2021 Radiation-induced skin injury (RISI) commonly occur in cancer patients who received radiotherapy and is one of the first clinical symptoms after suffering from nuclear exposure. Oxidative damage is the major causes of RISI.
Jiao Xue +20 more
doaj +2 more sources
Cinnamaldehyde Supplementation Reverts Endothelial Dysfunction in Rat Models of Diet-Induced Obesity: Role of NF-E2-Related Factor-2 [PDF]
Antioxidants, 2022 Cinnamaldehyde (CN) is an activator of NF-E2-related factor 2 (Nrf2), which has the potential to reduce endothelial dysfunction, oxidative stress and inflammation in metabolic disorders.
Cristina M. Sena +2 more
doaj +2 more sources
Astilbin exerts a neuroprotective effect by upregulating the signaling of nuclear NF-E2-related factor 2 in vitro [PDF]
HeliyonObjective: The present study aims to evaluate the impact of Astilbin (AST) on cortical neuron survival in vitro under conditions of oxygen-glucose deprivation and reoxygenation (OGD/R) and determine the role of NF-E2-related factor 2 (Nrf2) in this ...
Chao Guo +4 more
doaj +2 more sources
The Protective Effect of Sulforaphane against Oxidative Stress through Activation of NRF2/ARE Pathway in Human Granulosa Cells [PDF]
Cell Journal, 2021 Objective: Sulforaphane (SFN) is a natural free radical scavenger that can reduce oxidative stress (OS) through mediating nuclear factor (erythroid-derived 2)-like 2 (NF-E2-related factor 2 or NRF2)/antioxidant response element (ARE) signaling pathway ...
Sahar Esfandyari +7 more
doaj +1 more source
Changes of renal histopathology and the role of Nrf2/HO-1 in asphyxial cardiac arrest model in rats
Acta Cirúrgica Brasileira, 2021 Purpose To investigate the role of Nrf2/HO-1 in renal histopathological ailments time-dependently in asphyxial cardiac arrest (CA) rat model. Methods Eighty-eight Sprague Dawley male rats were divided into five groups of eight rats each.
Ali Jawad +11 more
doaj +1 more source
Age-Related Changes in Nuclear Factor Erythroid 2-Related Factor 2 and Reactive Oxygen Species and Mitochondrial Structure in the Tongues of Fischer 344 Rats [PDF]
Clinical and Experimental Otorhinolaryngology, 2017 Objectives Previously the authors reported age-related changes in the activities of anti-oxidative enzyme activities and protein expressions in the tongues of rats.
Min-Kwan Baek +7 more
doaj +1 more source
Stem Cell Reports, 2017 Nuclear factor erythroid-derived 2 (NF-E2) has been associated with megakaryocyte maturation and platelet production. Recently, an increased in NF-E2 activity has been implicated in myeloproliferative neoplasms.
Alessandro Di Tullio +4 more
doaj +1 more source
Cinnamaldehyde Prevents Endothelial Dysfunction Induced by High Glucose by Activating Nrf2
Cellular Physiology and Biochemistry, 2015 Background/Aims: It is well documented that hyperglycemia-induced oxidative stress is an important causative factor of endothelial dysfunction. Cinnamaldehyde (CA) is a key flavor compound in cinnamon essential oil that can enhance the antioxidant ...
Fang Wang +8 more
doaj +1 more source
Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role
Antioxidants, 2021 Chemoresistance represents the main obstacle to cancer treatment with both conventional and targeted therapy. Beyond specific molecular alterations, which can lead to targeted therapy, metabolic remodeling, including the control of redox status, plays an
Giuseppina Barrera +5 more
doaj +1 more source