NF-E2-Related Factor 2 (Nrf2) Ameliorates Radiation-Induced Skin Injury [PDF]
Frontiers in Oncology, 2021 Radiation-induced skin injury (RISI) commonly occur in cancer patients who received radiotherapy and is one of the first clinical symptoms after suffering from nuclear exposure. Oxidative damage is the major causes of RISI.
Jiao Xue +20 more
doaj +4 more sources
NF-E2-related factor 2 over-expression in mesenchymal stem cells to improve cellular cardiomyoplasty [PDF]
Electronic Physician, 2014 Myocardial infarction (MI) is the leading cause of death worldwide. Various therapeutic strategies have been introduced for MI treatment. In recent years, interest in utilizing mesenchymal stem cells (MSCs) for MI therapy has increased.
Mohammad Mohammadzadeh-Vardin +1 more
doaj +4 more sources
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2) [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2018 Nonalcoholic steatohepatitis (NASH) is associated with oxidative stress. We surmised that pharmacologic activation of NF-E2 p45-related factor 2 (Nrf2) using the acetylenic tricyclic bis(cyano enone) TBE-31 would suppress NASH because Nrf2 is a ...
Ritu S. Sharma +12 more
doaj +6 more sources
Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling. [PDF]
PLoS ONE, 2012 TGF-β plays a key role in the development of renal fibrosis. Suppressing the TGF-β signaling pathway is a possible therapeutic approach for preventing this disease, and reports have suggested that Nrf2 protects against renal fibrosis by inhibiting TGF-β ...
Chang Joo Oh +7 more
doaj +5 more sources
PLoS ONE, 2013 The number of the third-listed grant from the National Research Foundation is incorrect. The first sentence of the Funding Statement should read: "This work was supported by grants from the National Research Foundation (2011-0028659; WCU Program, R32-10064; Future-based Technology Development Program Bio Field, 2010-0019514; and Basic Science Research ...
Chang Joo Oh +7 more
doaj +4 more sources
The Protective Effect of Sulforaphane against Oxidative Stress through Activation of NRF2/ARE Pathway in Human Granulosa Cells [PDF]
Cell Journal, 2021 Objective: Sulforaphane (SFN) is a natural free radical scavenger that can reduce oxidative stress (OS) through mediating nuclear factor (erythroid-derived 2)-like 2 (NF-E2-related factor 2 or NRF2)/antioxidant response element (ARE) signaling pathway ...
Sahar Esfandyari +7 more
doaj +1 more source
NRF2 regulates HER1 signaling pathway to modulate the sensitivity of ovarian cancer cells to lapatinib and erlotinib [PDF]
, 2017 NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and ...
Bown, James L. +5 more
core +12 more sources
Changes of renal histopathology and the role of Nrf2/HO-1 in asphyxial cardiac arrest model in rats
Acta Cirúrgica Brasileira, 2021 Purpose To investigate the role of Nrf2/HO-1 in renal histopathological ailments time-dependently in asphyxial cardiac arrest (CA) rat model. Methods Eighty-eight Sprague Dawley male rats were divided into five groups of eight rats each.
Ali Jawad +11 more
doaj +1 more source
Age-Related Changes in Nuclear Factor Erythroid 2-Related Factor 2 and Reactive Oxygen Species and Mitochondrial Structure in the Tongues of Fischer 344 Rats [PDF]
Clinical and Experimental Otorhinolaryngology, 2017 Objectives Previously the authors reported age-related changes in the activities of anti-oxidative enzyme activities and protein expressions in the tongues of rats.
Min-Kwan Baek +7 more
doaj +1 more source
Nrf2b, Novel Zebrafish Paralog of Oxidant-responsive Transcription Factor NF-E2-related Factor 2 (NRF2) [PDF]
Journal of Biological Chemistry, 2012 NF-E2-related factor 2 (NRF2; also called NFE2L2) and related NRF family members regulate antioxidant defenses by activating gene expression via antioxidant response elements (AREs), but their roles in embryonic development are not well understood. We report here that zebrafish (Danio rerio), an important developmental model species, possesses six nrf ...
Alicia R, Timme-Laragy +7 more
openaire +2 more sources