Results 1 to 10 of about 210,121 (261)

NF-E2-related factor 2 over-expression in mesenchymal stem cells to improve cellular cardiomyoplasty [PDF]

Electronic Physician, 2014
Myocardial infarction (MI) is the leading cause of death worldwide. Various therapeutic strategies have been introduced for MI treatment. In recent years, interest in utilizing mesenchymal stem cells (MSCs) for MI therapy has increased.
Mohammad Mohammadzadeh-Vardin, Mehryar Habibi Roudkenar   +1 more
doaj   +7 more sources

NF-E2-Related Factor 2 (Nrf2) Ameliorates Radiation-Induced Skin Injury [PDF]

Frontiers in Oncology, 2021
Radiation-induced skin injury (RISI) commonly occur in cancer patients who received radiotherapy and is one of the first clinical symptoms after suffering from nuclear exposure. Oxidative damage is the major causes of RISI.
Jiao Xue, Jiao Xue, Jiao Xue, Chenxiao Yu, Chenxiao Yu, Chenxiao Yu, Chenxiao Yu, Yiting Tang, Yiting Tang, Wei Mo, Wei Mo, Zhicheng Tang, Zhicheng Tang, Wenjiong Sheng, Wenjiong Sheng, Yang Jiao, Yang Jiao, Wei Zhu, Wei Zhu, Jianping Cao, Jianping Cao   +20 more
doaj   +5 more sources

Astilbin exerts a neuroprotective effect by upregulating the signaling of nuclear NF-E2-related factor 2 in vitro [PDF]

Heliyon
Objective: The present study aims to evaluate the impact of Astilbin (AST) on cortical neuron survival in vitro under conditions of oxygen-glucose deprivation and reoxygenation (OGD/R) and determine the role of NF-E2-related factor 2 (Nrf2) in this ...
Chao Guo, Ying Yin, Zhongying Ma, Fangqin Xu, Shiquan Wang   +4 more
doaj   +4 more sources

Cinnamaldehyde Supplementation Reverts Endothelial Dysfunction in Rat Models of Diet-Induced Obesity: Role of NF-E2-Related Factor-2 [PDF]

Antioxidants, 2022
Cinnamaldehyde (CN) is an activator of NF-E2-related factor 2 (Nrf2), which has the potential to reduce endothelial dysfunction, oxidative stress and inflammation in metabolic disorders.
Cristina M. Sena, Ana Pereira, Raquel M. Seiça   +2 more
doaj   +2 more sources

Expression of NF-E2-related factor 2 in a rat dural arteriovenous fistula model. [PDF]

Exp Ther Med, 2017
Intracranial dural arteriovenous fistulas (DAVFs) are complex intracranial vascular malformations that may lead to hemorrhage. Although the precise mechanisms by which DAVFs occur remain unknown, dural angiogenesis may be a vital factor in its pathogenesis.
Dou L, Yu W.
europepmc   +4 more sources

Triphlorethol‐A induces heme oxygenase‐1 via activation of ERK and NF‐E2 related factor 2 transcription factor [PDF]

FEBS Letters, 2007
Triphlorethol‐A, phlorotannin found inEcklonia cava, induced heme oxygenase‐1 (HO‐1) expression at mRNA and protein levels, leading to increased HO‐1 activity. Transcription factor NF‐E2 related factor 2 (Nrf2) regulates antioxidant response element (ARE) of phase 2 detoxifying and antioxidant enzymes.
Kang, Kyoung Ah, Lee, Kyoung Hwa, Park, Jae Woo, Lee, Nam Ho, Na, Hye Kyung, Surh, Young Joon, You, Ho Jin, Chung, Myung Hee, Hyun, Jin Won   +8 more
openaire   +4 more sources

NF-E2-Related Factor 2 Regulates Interferon Receptor Expression and Alters Macrophage Polarization in Lupus. [PDF]

Arthritis Rheumatol, 2020
ObjectivePristane‐induced lupus is associated with nonresolving inflammation and deficiency of proresolving macrophages. Proresolving nonclassic macrophages (NCMs) are less responsive to type I interferon (IFN) than classic macrophages (CMs; which are proinflammatory), reflecting their relative expression levels of the type I IFN receptor (IFNAR). This
Han S, Zhuang H, Lee PY, Li M, Yang L, Nigrovic PA, Reeves WH.   +6 more
europepmc   +4 more sources

The transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene?

FASEB J, 2013
The transcription factor Nrf2 is responsible for regulating a battery of antioxidant and cellular protective genes, primarily in response to oxidative stress. A member of the cap ‘n’ collar family of transcription factors, Nrf2 activation is tightly controlled by a series of signaling events.
Shelton P, Jaiswal AK.
europepmc   +4 more sources

Nrf2b, Novel Zebrafish Paralog of Oxidant-responsive Transcription Factor NF-E2-related Factor 2 (NRF2) [PDF]

Journal of Biological Chemistry, 2012
NF-E2-related factor 2 (NRF2; also called NFE2L2) and related NRF family members regulate antioxidant defenses by activating gene expression via antioxidant response elements (AREs), but their roles in embryonic development are not well understood. We report here that zebrafish (Danio rerio), an important developmental model species, possesses six nrf ...
Alicia R, Timme-Laragy, Sibel I, Karchner, Diana G, Franks, Matthew J, Jenny, Rachel C, Harbeitner, Jared V, Goldstone, Andrew G, McArthur, Mark E, Hahn   +7 more
openaire   +4 more sources

Association of NF-E2 Related Factor 2 (Nrf2) and inflammatory cytokines in recent onset Type 2 Diabetes Mellitus. [PDF]

Sci Rep, 2018
AbstractWe investigated the association of redox regulator Nuclear factor erythroid 2-related factor 2 (Nrf2) and inflammatory cytokines as well as clinical remission in patients with recent onset type 2 diabetes (DM). Blood was collected from 180 DM patients (105 males/75 females) and 150 control subjects (86 males/64 females).
Sireesh D, Dhamodharan U, Ezhilarasi K, Vijay V, Ramkumar KM.   +4 more
europepmc   +4 more sources