The Relationship between Nrf2 and HO-1 with the Severity of COVID-19 Disease
Medicina, 2022 Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) have significant roles in the development of a hyperinflammatory state in infectious diseases.
Damir Mihić +8 more
doaj +1 more source
Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2
Journal of Experimental & Clinical Cancer Research, 2012 Background Propofol is one of the most commonly used intravenous anaesthetic agents during cancer resection surgery, but the effect of propofol on gallbladder cancer is not clear.
Zhang Lingmin +5 more
doaj +1 more source
Pharmaceutical Biology, 2020 Context 5-Caffeoylquinic acid (5-CQA) is one of the most abundant compounds found in natural foods including coffee. Objective We investigated whether 5-CQA had a cytoprotective effect through the NF-E2-related factor 2 (Nrf2)-antioxidant response ...
XiQiang Chen +6 more
doaj +1 more source
Sulforaphane improves voiding function via the preserving mitochondrial function in diabetic rats
Journal of the Formosan Medical Association, 2020 Background: Hyperglycemia evoked oxidative stress contributing to diabetes (DM)-induced voiding dysfunction. We explored whether antioxidant sulforaphane,a NF-E2-related nuclear factor erythroid-2 (Nrf-2) activator, may ameliorate DM-induced bladder ...
Chia-Fa Lin +5 more
doaj +1 more source
Monopoles, Duality and Chiral Symmetry Breaking in N=2 Supersymmetric QCD [PDF]
, 1994 We study four dimensional $N=2$ supersymmetric gauge theories with matter multiplets. For all such models for which the gauge group is $SU(2)$, we derive the exact metric on the moduli space of quantum vacua and the exact spectrum of the stable massive ...
Affleck +33 more
core +2 more sources
Research progress of targeting on Nrf2/ARE pathway in the treatment of ischemic stroke [PDF]
Jichu yixue yu linchuang, 2023 Recently, mounting evidences have suggested the therapeutic potential of Nrf2/ARE activators for treating Ischemic stroke. Moreover, several Nrf2 activators attenuate ischemic stroke-induced brain injury in several transient focal cerebral ischemia ...
YANG Xiaofei, LI Qiang, LI Yanfeng, WANG Hongquan
doaj +1 more source
Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]
, 2019 Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y. +3 more
core +3 more sources
Targeting the NF-E2-related factor 2 pathway: A novel strategy for glioblastoma (Review)
Oncology Reports, 2014 Glioblastoma is the most common and malignant subtype among all brain tumors. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential component of cellular defense against a variety of endogenous and exogenous stresses. A marked increase in research over the past few decades focusing on Nrf2 and its role in regulating glioblastoma has ...
Jianhong, Zhu +6 more
openaire +3 more sources
Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas [PDF]
, 2011 Background Triple-negative breast cancer (TNBC) and basal-like breast cancer (BLBC) are breast cancer subtypes with an especially poor prognosis. 8-Hydroxydeoxyguanosine (8-OHdG) is a widely used marker of oxidative stress and the redox-state-regulating ...
Peeter Karihtala +3 more
core +1 more source
Supplementation of Alleviates Vascular Inflammation in Diabetic Mice [PDF]
Diabetes & Metabolism JournalBackground Gut microbiota is closely related to the occurrence and development of diabetes and affects the prognosis of diabetic complications, and the underlying mechanisms are only partially understood. We aimed to explore the possible link between the
Tian Zhou +10 more
doaj +1 more source