Results 41 to 50 of about 210,121 (261)

Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture [PDF]

, 2004
Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric oxide synthase
Damian J Murphy, Dunmore, Simon J., Murphy Damian J, Carson Ray J, Rodrigo, Nalinda, Seyffarth Gunter, Nelson, Paul N., Dunmore Simon J, Simon J Dunmore, Nalinda Rodrigo, Carson, Ray J., Seyffarth, Gunther, Rodrigo Nalinda, Paul N Nelson, Murphy, Damian J., Nelson Paul N, Gunter Seyffarth, Ray J Carson   +17 more
core   +1 more source

The Relationship between Nrf2 and HO-1 with the Severity of COVID-19 Disease

Medicina, 2022
Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) have significant roles in the development of a hyperinflammatory state in infectious diseases.
Damir Mihić, Domagoj Loinjak, Lana Maričić, Robert Smolić, Ines Šahinović, Kristina Steiner, Sven Viland, Vatroslav Šerić, Mario Duvnjak   +8 more
doaj   +1 more source

Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2

Journal of Experimental & Clinical Cancer Research, 2012
Background Propofol is one of the most commonly used intravenous anaesthetic agents during cancer resection surgery, but the effect of propofol on gallbladder cancer is not clear.
Zhang Lingmin, Wang Ning, Zhou Suna, Ye Wenguang, Jing Guixia, Zhang Mingxin   +5 more
doaj   +1 more source

5-Caffeoylquinic acid ameliorates oxidative stress-mediated cell death via Nrf2 activation in hepatocytes

Pharmaceutical Biology, 2020
Context 5-Caffeoylquinic acid (5-CQA) is one of the most abundant compounds found in natural foods including coffee. Objective We investigated whether 5-CQA had a cytoprotective effect through the NF-E2-related factor 2 (Nrf2)-antioxidant response ...
XiQiang Chen, Ji Hye Yang, Sam Seok Cho, Jae Hoon Kim, JiaQian Xu, Kyuhwa Seo, Sung Hwan Ki   +6 more
doaj   +1 more source

Sulforaphane improves voiding function via the preserving mitochondrial function in diabetic rats

Journal of the Formosan Medical Association, 2020
Background: Hyperglycemia evoked oxidative stress contributing to diabetes (DM)-induced voiding dysfunction. We explored whether antioxidant sulforaphane,a NF-E2-related nuclear factor erythroid-2 (Nrf-2) activator, may ameliorate DM-induced bladder ...
Chia-Fa Lin, Tsung-Hung Chueh, Cheng-Hsun Chung, Shue-Dong Chung, Tzu-Ching Chang, Chiang-Ting Chien   +5 more
doaj   +1 more source

Bromodomain and Extraterminal Proteins Suppress NF-E2–Related Factor 2–Mediated Antioxidant Gene Expression [PDF]

The Journal of Immunology, 2014
Abstract Oxidative stress, a pathogenetic factor in many conditions, including chronic obstructive pulmonary disease, arises due to accumulation of reactive oxygen species and defective antioxidant defenses in the lungs. The latter is due, at least in part, to impaired activation of NF-E2–related factor 2 (Nrf2), a transcription factor ...
Charalambos, Michaeloudes, Nicolas, Mercado, Colin, Clarke, Pankaj K, Bhavsar, Ian M, Adcock, Peter J, Barnes, Kian Fan, Chung   +6 more
openaire   +2 more sources

Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ : prostaglandin E2 dependent proliferation of growth plate chondrocytes [PDF]

, 2006
Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential.
Nüsing, Rolf M., Neuland, Pia, Brochhausen, Christoph, Rolf M Nüsing, Günter Klaus, Kirkpatrick, Charles James, Christoph Brochhausen, Klaus, Günter, Pia Neuland, C James Kirkpatrick   +9 more
core   +1 more source

Interleukin-4 downregulates nuclear factor-erythroid 2 (NF-E2) expression in primary megakaryocytes and in megakaryoblastic cell lines [PDF]

, 2001
The trascriptional factor nuclear factor-erythroid 2 (NF-E2) is one of the few transcription factors known to be functionally linked to the megakaryocytic lineage, where it regulates terminal megakaryocyte maturation and platelet formation.
Luatti S., Valdre L., Martinelli G., Amabile M., Vianelli N., Catani L., Tura S.   +6 more
core   +1 more source

HIF-1α, a novel piece in the NF-κB puzzle [PDF]

, 2015
Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core   +1 more source

Supplementation of Alleviates Vascular Inflammation in Diabetic Mice [PDF]

Diabetes & Metabolism Journal
Background Gut microbiota is closely related to the occurrence and development of diabetes and affects the prognosis of diabetic complications, and the underlying mechanisms are only partially understood. We aimed to explore the possible link between the
Tian Zhou, Shuo Qiu, Liang Zhang, Yangni Li, Jing Zhang, Donghua Shen, Ping Zhao, Lijun Yuan, Lianbi Zhao, Yunyou Duan, Changyang Xing   +10 more
doaj   +1 more source