Results 51 to 60 of about 210,121 (261)

Corticotropin-releasing hormone interacts with interleukin-1 to regulate prostaglandin H synthase-2 expression in human myometrium during pregnancy and labor [PDF]

, 2013
Context: The onset of labor appears to involve the activation of myometrial inflammatory pathways, and transcription factors such as nuclear factor-κB (NF-κB) control expression of the contraction-associated proteins required to induce a procontractile ...
Grammatopoulos, Dimitris, Bari, Muhammad F., Lu, Buyu, Markovic, Danijela, Lu, B., Vatish, Manu   +5 more
core   +1 more source

Disulfiram/Copper Complex Induces Cytotoxicity in Pancreatic Cancer Cells and 5-Fluorouracil-Resistant Cells through Nuclear Factor E2-Related Factor-2 Suppression and Reactive Oxygen Species Modulation

Gut and Liver
Background/Aims : Pancreatic ductal adenocarcinoma (PDAC) is a challenging cancer to treat and has a poor prognosis and limited treatment options. In this study, the anticancer effects of disulfiram combined with copper (DSF/Cu) on PDAC cells, including ...
Eun Kyoung Kim, Cheong Ran Je, Sung Ill Jang, Jung Hyun Jo, See Young Lee, Young Ju Lee, Jae Hee Cho   +6 more
doaj   +1 more source

Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model

Drug Design, Development and Therapy, 2022
Shilin Xiao, Ying Zhou, Qianyu Wang, Dong Yang Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Dong Yang, Department of ...
Xiao S, Zhou Y, Wang Q, Yang D
doaj  

IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. [PDF]

, 2011
Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a key role in the pathogenesis of osteoarthritis (OA). Growth factors (GFs) capable of antagonizing the catabolic actions of cytokines may have therapeutic potential in the treatment of OA.
Franziska Busch, Azadeh Montaseri, Jafar Soleimani Rad, Busch, Franziska, Montaseri, Azadeh, Rad, Jafar Soleimani, Mehdi Shakibaei, Ali Mobasheri, Constance Aldinger, Aldinger, Constance, Shakibaei, Mehdi, Mobasheri, Ali, Constanze Buhrmann, Buhrmann, Constanze   +13 more
core   +1 more source

Artemisitene Alters LPS-Induced Oxidative stress, inflammation and Ferroptosis in Liver Through Nrf2/HO-1 and NF-kB Pathway

Frontiers in Pharmacology, 2023
The liver plays a critical role in sepsis, which is a serious worldwide public health problem. A novel mechanism of controlled cell death called ferroptosis has recently been described.
Changzhi Zhao, Changzhi Zhao, Congshu Xiao, Songqiao Feng, Jianxin Bai   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

IKKα regulation of canonical NF-κB activation downstream of Nod1-mediated peptidoglycan recognition : "and" Endocytosis-independent function of clathrin heavy chain in the control of basal NF-κB activation [PDF]

, 2010
NF-κB is a transcription factor involved in the regulation of inflammation and innate immunity. The IκB kinase (IKK) complex contains two catalytic subunits, IKKα and IKKβ, and plays an essential role in the activation of NF-κB through the ...
Kim, Man Lyang
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Nrf2 regulates ROS production by mitochondria and NADPH oxidase. [PDF]

, 2015
Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like ECH associated protein 1 (Keap1) thereby providing inducible antioxidant ...
Dinkova-Kostova, AT, Holmström, Kira M., Stjepana Kovaca, Kovac, S, Plamena R. Angelovaa, Ying Zhangb, Andrey Y. Abramova, Abramov, Andrey Y., Angelova, PR, Zhang, Y, Abramov, AY, Angelova, Plamena R., Kovac, Stjepana, Zhang, Ying, Kira M. Holmströma, Holmström, KM, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T., Albena T   +18 more
core   +1 more source

Proteinase-Activated Receptor-2–Triggered Prostaglandin E2 Release, but Not Cyclooxygenase-2 Upregulation, Requires Activation of the Phosphatidylinositol 3–Kinase / Akt / Nuclear Factor-κB Pathway in Human Alveolar Epithelial Cells

Journal of Pharmacological Sciences, 2009
Proteinase-activated receptor-2 (PAR2) triggers upregulation of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) formation in human alveolar epithelial A549 cells.
Kazumi Moriyuki, Fumiko Sekiguchi, Kaori Matsubara, Hiroyuki Nishikawa, Atsufumi Kawabata   +4 more
doaj   +1 more source