Results 31 to 40 of about 151,448 (273)

Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1 [PDF]

, 2016
Medicinal plants from the Egyptian Sinai Peninsula are widely used in traditional Bedouin medicine to treat a range of conditions including cancer, and as such are a promising resource for novel anti-cancer compounds.
AA Moustafa, AA Sprouse, Ahmed R. Hamed, Albena T. Dinkova-Kostova, AT Dinkova-Kostova, C Bailey, CR Zhao, D Bown, H-S Kim, HJ Prochaska, HR El-Seedi, IK Khafagi, JD Phillipson, JW Fahey, KH Batanouny, KH Batanouny, L Boulos, LH Hurley, M Saxena, Maureen Higgins, MEF Hegazy, MEF Hegazy, MEF Hegazy, MF Hegazy, MJ Balunas, MM Manson, MM Soltan, Mohamed-Elamir F. Hegazy, Nahla S. Abdel-Azim, NS Abdel-Azim, Paul W. Pare, SK Ali, Tarik A. Mohamed, TF Eissa, V Kuete, W Elmasri, Y Zhang, YJ Surh   +37 more
core   +3 more sources

Annexin A5 Protects SH-SY5Y Cells against L-Glutamate-Induced Cytotoxicity [PDF]

Iranian Journal of Medical Sciences
Background: L- glutamate- induced neurotoxicity is linked to neuronal loss in neurodegenerative diseases and stroke. Annexin A5 (ANXA5) is a cytosolic protein that binds calcium in eukaryotic organisms. This study aimed to evaluate the protective effects
Zahra Abedini, Marzieh Mehdieh, Mohammad Ali Takhshid   +2 more
doaj   +1 more source

Methylcobalamin Protects Melanocytes from H2O2-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway

Drug Design, Development and Therapy, 2021
Ran An,1,2 Dong Li,1 Yingying Dong,1 Qiuyun She,1 Ting Zhou,1 Xiaoqi Nie,1 Ronghua Pan,1 Yunhua Deng1 1Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of ...
An R, Li D, Dong Y, She Q, Zhou T, Nie X, Pan R, Deng Y   +7 more
doaj  

Neuroprotective effects of an Nrf2 agonist on high glucose-induced damage in HT22 cells

Biological Research, 2019
Background Oxidative stress is the hallmark of diabetic encephalopathy, which may be caused by hyperglycaemic toxicity. We aimed to discover pharmacologic targets to restore redox homeostasis. We identified the transcription factor Nrf2 as such a target.
Jiangpei Zhao, Lerong Liu, Xia Li, Lingxiao Zhang, Jing Lv, Xueli Guo, Hui Chen, Tongfeng Zhao   +7 more
doaj   +1 more source

Cardamonin Inhibits Oxazolone-Induced Atopic Dermatitis by the Induction of NRF2 and the Inhibition of Th2 Cytokine Production

Antioxidants, 2020
The skin is constantly exposed to various types of chemical stresses that challenge the immune cells, leading to the activation of T cell-mediated hypersensitivity reactions including atopic dermatitis.
Ok-Kyung Yoo, Won Jun Choi, Young-Sam Keum   +2 more
doaj   +1 more source

Involvement of CK2 in activation of electrophilic genes in endothelial cells by oxidized phospholipids[S]

Journal of Lipid Research, 2011
Oxidized phospholipids (OxPLs) are increasingly recognized as pleiotropic lipid mediators demonstrating a variety of biological activities. In particular, OxPLs induce electrophilic stress response and stimulate expression of NF-E2-related factor 2 (NRF2)
Taras Afonyushkin, Olga V. Oskolkova, Bernd R. Binder, Valery N. Bochkov   +3 more
doaj   +1 more source

Role of G{alpha}12 and G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor [PDF]

, 2007
G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress.
Cho, Min Kyung, Choi, Sangdun, Hwang, Jong-Ik, Ki, Sung Hwan, Kim, Sang Geon, Kim, Won Dong, Lee, Chang Ho   +6 more
core   +2 more sources

Triphlorethol‐A induces heme oxygenase‐1 via activation of ERK and NF‐E2 related factor 2 transcription factor [PDF]

FEBS Letters, 2007
Triphlorethol‐A, phlorotannin found inEcklonia cava, induced heme oxygenase‐1 (HO‐1) expression at mRNA and protein levels, leading to increased HO‐1 activity. Transcription factor NF‐E2 related factor 2 (Nrf2) regulates antioxidant response element (ARE) of phase 2 detoxifying and antioxidant enzymes.
Kang, Kyoung Ah, Lee, Kyoung Hwa, Park, Jae Woo, Lee, Nam Ho, Na, Hye Kyung, Surh, Young Joon, You, Ho Jin, Chung, Myung Hee, Hyun, Jin Won   +8 more
openaire   +2 more sources

Nrf2 plays a critical role in the metabolic response during and after spaceflight

Communications Biology, 2021
Akira Uruno et al. report the volume of epidydimal white adipose tissue and plasma glycerophospholipid and sphingolipid levels in mice increase during spaceflight.
Akira Uruno, Daisuke Saigusa, Takafumi Suzuki, Akane Yumoto, Tomohiro Nakamura, Naomi Matsukawa, Takahiro Yamazaki, Ristumi Saito, Keiko Taguchi, Mikiko Suzuki, Norio Suzuki, Akihito Otsuki, Fumiki Katsuoka, Eiji Hishinuma, Risa Okada, Seizo Koshiba, Yoshihisa Tomioka, Ritsuko Shimizu, Masaki Shirakawa, Thomas W. Kensler, Dai Shiba, Masayuki Yamamoto   +21 more
doaj   +1 more source

CR6-interacting Factor 1 (CRIF1) Regulates NF-E2-related Factor 2 (NRF2) Protein Stability by Proteasome-mediated Degradation [PDF]

Journal of Biological Chemistry, 2010
Free radicals generated by oxidative stress cause damage that can contribute to numerous chronic diseases. Mammalian cells respond to this damage by increased transcription of cytoprotective phase II genes, which are regulated by NRF2. Previously, it has been shown that NRF2 protein levels increase after oxidative stress because its negative regulator,
Kang, Hyo Jin, Hong, Young Bin, Kim, Hee Jeong, Bae, Insoo   +3 more
openaire   +2 more sources