Results 31 to 40 of about 210,121 (261)

Nuclear factor-erythroid 2 (NF-E2) expression in normal and malignant megakaryocytopoiesis [PDF]

, 2002
Although the transcription factor nuclear factor-erythroid 2 (NF-E2) is known to be functionally linked to the megakaryocytic lineage, little is known about its role in malignant megakaryocytes.
CATANI L, Valdre L., Moi P., TURA S, Catani L., AMABILE M, MOI, PAOLO, PATTACINI L, VIANELLI N, MARTINELLI G, Martinelli G., Amabile M., FAGIOLI ME, MARINI, MARIA GIUSEPPINA, POLI M, Pattacini L., VALDRÈ L, Tura S., GUGLIOTTA L, Marini M. G., BACCARANI M., Vianelli N., Fagioli M. E., Poli M., Gugliotta L.   +24 more
core   +1 more source

Methylcobalamin Protects Melanocytes from H2O2-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway

Drug Design, Development and Therapy, 2021
Ran An,1,2 Dong Li,1 Yingying Dong,1 Qiuyun She,1 Ting Zhou,1 Xiaoqi Nie,1 Ronghua Pan,1 Yunhua Deng1 1Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of ...
An R, Li D, Dong Y, She Q, Zhou T, Nie X, Pan R, Deng Y   +7 more
doaj  

Annexin A5 Protects SH-SY5Y Cells against L-Glutamate-Induced Cytotoxicity [PDF]

Iranian Journal of Medical Sciences
Background: L- glutamate- induced neurotoxicity is linked to neuronal loss in neurodegenerative diseases and stroke. Annexin A5 (ANXA5) is a cytosolic protein that binds calcium in eukaryotic organisms. This study aimed to evaluate the protective effects
Zahra Abedini, Marzieh Mehdieh, Mohammad Ali Takhshid   +2 more
doaj   +1 more source

Neuroprotective effects of an Nrf2 agonist on high glucose-induced damage in HT22 cells

Biological Research, 2019
Background Oxidative stress is the hallmark of diabetic encephalopathy, which may be caused by hyperglycaemic toxicity. We aimed to discover pharmacologic targets to restore redox homeostasis. We identified the transcription factor Nrf2 as such a target.
Jiangpei Zhao, Lerong Liu, Xia Li, Lingxiao Zhang, Jing Lv, Xueli Guo, Hui Chen, Tongfeng Zhao   +7 more
doaj   +1 more source

Cardamonin Inhibits Oxazolone-Induced Atopic Dermatitis by the Induction of NRF2 and the Inhibition of Th2 Cytokine Production

Antioxidants, 2020
The skin is constantly exposed to various types of chemical stresses that challenge the immune cells, leading to the activation of T cell-mediated hypersensitivity reactions including atopic dermatitis.
Ok-Kyung Yoo, Won Jun Choi, Young-Sam Keum   +2 more
doaj   +1 more source

Targeting the NF-E2-related factor 2 pathway: A novel strategy for glioblastoma (Review)

Oncology Reports, 2014
Glioblastoma is the most common and malignant subtype among all brain tumors. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential component of cellular defense against a variety of endogenous and exogenous stresses. A marked increase in research over the past few decades focusing on Nrf2 and its role in regulating glioblastoma has ...
Jianhong, Zhu, Handong, Wang, Youwu, Fan, Yixing, Lin, Li, Zhang, Xiangjun, Ji, Mengliang, Zhou   +6 more
openaire   +3 more sources

Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]

, 2014
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival ...
Biddlestone, John, Mudie, Sharon, Bandarra, Daniel, Muller, H. Arno, Rocha, Sonia   +4 more
core   +1 more source

Involvement of CK2 in activation of electrophilic genes in endothelial cells by oxidized phospholipids[S]

Journal of Lipid Research, 2011
Oxidized phospholipids (OxPLs) are increasingly recognized as pleiotropic lipid mediators demonstrating a variety of biological activities. In particular, OxPLs induce electrophilic stress response and stimulate expression of NF-E2-related factor 2 (NRF2)
Taras Afonyushkin, Olga V. Oskolkova, Bernd R. Binder, Valery N. Bochkov   +3 more
doaj   +1 more source

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes, but not with insulin resistance [PDF]

, 2014
Mice lacking transcription factor NF-E2 p45-related factor 2 (Nrf2) develop more severe non-alcoholic steatohepatitis (NASH), with cirrhosis, than wild-type (Nrf2(+/+)) mice when fed a high-fat (HF) diet for 24 weeks.
Chowdhry, Sudhir, McCrimmon, Rory J.; id_orcid, Meakin, Paul J.; id_orcid, Dinkova-Kostova, AT, Meakin, PJ, Ashford, FB, Walsh, Shaun V., Chowdhry, S, Sharma, Ritu S., Walsh, SV, Ashford, Fiona B., Sharma, RS, Dillon, JF, Dillon, John F.; id_orcid, Hayes, John D, Hayes, JD, Dinkova-Kostova, Albena T.; id_orcid, Ashford, MLJ, Ashford, Michael L. J.; id_orcid, McCrimmon, RJ   +19 more
core   +1 more source

Nrf2 plays a critical role in the metabolic response during and after spaceflight

Communications Biology, 2021
Akira Uruno et al. report the volume of epidydimal white adipose tissue and plasma glycerophospholipid and sphingolipid levels in mice increase during spaceflight.
Akira Uruno, Daisuke Saigusa, Takafumi Suzuki, Akane Yumoto, Tomohiro Nakamura, Naomi Matsukawa, Takahiro Yamazaki, Ristumi Saito, Keiko Taguchi, Mikiko Suzuki, Norio Suzuki, Akihito Otsuki, Fumiki Katsuoka, Eiji Hishinuma, Risa Okada, Seizo Koshiba, Yoshihisa Tomioka, Ritsuko Shimizu, Masaki Shirakawa, Thomas W. Kensler, Dai Shiba, Masayuki Yamamoto   +21 more
doaj   +1 more source