Results 31 to 40 of about 34,567,041 (234)

Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2

Journal of Experimental & Clinical Cancer Research, 2012
Background Propofol is one of the most commonly used intravenous anaesthetic agents during cancer resection surgery, but the effect of propofol on gallbladder cancer is not clear.
Zhang Lingmin, Wang Ning, Zhou Suna, Ye Wenguang, Jing Guixia, Zhang Mingxin   +5 more
doaj   +1 more source

5-Caffeoylquinic acid ameliorates oxidative stress-mediated cell death via Nrf2 activation in hepatocytes

Pharmaceutical Biology, 2020
Context 5-Caffeoylquinic acid (5-CQA) is one of the most abundant compounds found in natural foods including coffee. Objective We investigated whether 5-CQA had a cytoprotective effect through the NF-E2-related factor 2 (Nrf2)-antioxidant response ...
XiQiang Chen, Ji Hye Yang, Sam Seok Cho, Jae Hoon Kim, JiaQian Xu, Kyuhwa Seo, Sung Hwan Ki   +6 more
doaj   +1 more source

Sulforaphane improves voiding function via the preserving mitochondrial function in diabetic rats

Journal of the Formosan Medical Association, 2020
Background: Hyperglycemia evoked oxidative stress contributing to diabetes (DM)-induced voiding dysfunction. We explored whether antioxidant sulforaphane,a NF-E2-related nuclear factor erythroid-2 (Nrf-2) activator, may ameliorate DM-induced bladder ...
Chia-Fa Lin, Tsung-Hung Chueh, Cheng-Hsun Chung, Shue-Dong Chung, Tzu-Ching Chang, Chiang-Ting Chien   +5 more
doaj   +1 more source

Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture [PDF]

, 2004
Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric oxide synthase
Damian J Murphy, Dunmore, Simon J., Murphy Damian J, Carson Ray J, Rodrigo, Nalinda, Seyffarth Gunter, Nelson, Paul N., Dunmore Simon J, Simon J Dunmore, Nalinda Rodrigo, Carson, Ray J., Seyffarth, Gunther, Rodrigo Nalinda, Paul N Nelson, Murphy, Damian J., Nelson Paul N, Gunter Seyffarth, Ray J Carson   +17 more
core   +1 more source

The Neutrophil Gelatinase-associated lipocalin (NGAL), a NF-kB regulated gene, is a survival factor for thyroid neoplastic cells [PDF]

, 2008
NF-κB is constitutively activated in primary human thyroid tumors, particularly in those of anaplastic type. The inhibition of NF-κB activity in the human anaplastic thyroid carcinoma cell line, FRO, leads to an increased susceptibility to ...
Iannetti, Alessio
core   +1 more source

Supplementation of Alleviates Vascular Inflammation in Diabetic Mice [PDF]

Diabetes & Metabolism Journal
Background Gut microbiota is closely related to the occurrence and development of diabetes and affects the prognosis of diabetic complications, and the underlying mechanisms are only partially understood. We aimed to explore the possible link between the
Tian Zhou, Shuo Qiu, Liang Zhang, Yangni Li, Jing Zhang, Donghua Shen, Ping Zhao, Lijun Yuan, Lianbi Zhao, Yunyou Duan, Changyang Xing   +10 more
doaj   +1 more source

HIF-1α, a novel piece in the NF-κB puzzle [PDF]

, 2015
Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core   +1 more source

Corticotropin-releasing hormone interacts with interleukin-1 to regulate prostaglandin H synthase-2 expression in human myometrium during pregnancy and labor [PDF]

, 2013
Context: The onset of labor appears to involve the activation of myometrial inflammatory pathways, and transcription factors such as nuclear factor-κB (NF-κB) control expression of the contraction-associated proteins required to induce a procontractile ...
Grammatopoulos, Dimitris, Bari, Muhammad F., Lu, Buyu, Markovic, Danijela, Lu, B., Vatish, Manu   +5 more
core   +1 more source

Disulfiram/Copper Complex Induces Cytotoxicity in Pancreatic Cancer Cells and 5-Fluorouracil-Resistant Cells through Nuclear Factor E2-Related Factor-2 Suppression and Reactive Oxygen Species Modulation

Gut and Liver
Background/Aims : Pancreatic ductal adenocarcinoma (PDAC) is a challenging cancer to treat and has a poor prognosis and limited treatment options. In this study, the anticancer effects of disulfiram combined with copper (DSF/Cu) on PDAC cells, including ...
Eun Kyoung Kim, Cheong Ran Je, Sung Ill Jang, Jung Hyun Jo, See Young Lee, Young Ju Lee, Jae Hee Cho   +6 more
doaj   +1 more source

Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model

Drug Design, Development and Therapy, 2022
Shilin Xiao, Ying Zhou, Qianyu Wang, Dong Yang Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Dong Yang, Department of ...
Xiao S, Zhou Y, Wang Q, Yang D
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