NF‐E2–Related Factor 2 Regulates Interferon Receptor Expression and Alters Macrophage Polarization in Lupus [PDF]
Arthritis & Rheumatology, 2020 ObjectivePristane‐induced lupus is associated with nonresolving inflammation and deficiency of proresolving macrophages. Proresolving nonclassic macrophages (NCMs) are less responsive to type I interferon (IFN) than classic macrophages (CMs; which are proinflammatory), reflecting their relative expression levels of the type I IFN receptor (IFNAR). This
Shuhong Han +6 more
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Cinnamaldehyde Supplementation Reverts Endothelial Dysfunction in Rat Models of Diet-Induced Obesity: Role of NF-E2-Related Factor-2 [PDF]
Antioxidants, 2022 Cinnamaldehyde (CN) is an activator of NF-E2-related factor 2 (Nrf2), which has the potential to reduce endothelial dysfunction, oxidative stress and inflammation in metabolic disorders.
Cristina M. Sena +2 more
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The transcription factor NF‐E2‐related Factor 2 (Nrf2): a protooncogene?
The FASEB Journal, 2012 The transcription factor Nrf2 is responsible for regulating a battery of antioxidant and cellular protective genes, primarily in response to oxidative stress. A member of the cap ‘n’ collar family of transcription factors, Nrf2 activation is tightly controlled by a series of signaling events.
Phillip, Shelton, Anil K, Jaiswal
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Expression of NF‑E2‑related factor 2 in a rat dural arteriovenous fistula model [PDF]
Experimental and Therapeutic Medicine, 2017 Intracranial dural arteriovenous fistulas (DAVFs) are complex intracranial vascular malformations that may lead to hemorrhage. Although the precise mechanisms by which DAVFs occur remain unknown, dural angiogenesis may be a vital factor in its pathogenesis.
Limin, Dou, Wenhua, Yu
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Association of NF-E2 Related Factor 2 (Nrf2) and inflammatory cytokines in recent onset Type 2 Diabetes Mellitus [PDF]
Scientific Reports, 2018 AbstractWe investigated the association of redox regulator Nuclear factor erythroid 2-related factor 2 (Nrf2) and inflammatory cytokines as well as clinical remission in patients with recent onset type 2 diabetes (DM). Blood was collected from 180 DM patients (105 males/75 females) and 150 control subjects (86 males/64 females).
Sireesh, Dornadula +4 more
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Astilbin exerts a neuroprotective effect by upregulating the signaling of nuclear NF-E2-related factor 2 in vitro [PDF]
HeliyonObjective: The present study aims to evaluate the impact of Astilbin (AST) on cortical neuron survival in vitro under conditions of oxygen-glucose deprivation and reoxygenation (OGD/R) and determine the role of NF-E2-related factor 2 (Nrf2) in this ...
Chao Guo +4 more
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Sirtuin 1 Promotes Hyperoxia-Induced Lung Epithelial Cell Death Independent of NF-E2–Related Factor 2 Activation [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2016 Lung epithelial cell damage accompanied by death is a cardinal feature of toxicant- and prooxidant-induced acute lung injury. The transcription factor nuclear factor (erythroid-derived 2)-like 2 (NEF2L2 or NRF2) activates several antioxidant enzymes (AOEs) and prosurvival genes in response to oxidant stress, and its deficiency enhances susceptibility ...
Haranatha R, Potteti +5 more
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Seven in Absentia Homolog 2 (Siah2) Protein Is a Regulator of NF-E2-related Factor 2 (Nrf2)* [PDF]
Journal of Biological Chemistry, 2013 Under pathological conditions such as ischemia-reperfusion, Nrf2 acts as a key regulator of cellular oxidative response. Provided that Nrf2 is sensitive to hypoxia during ischemia, Nrf2 may affect reactive oxygen species metabolism during reoxygenation.
Kazunobu, Baba +2 more
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Correlation between expression of NF-E2-related factor 2 and progression of gastric cancer.
International journal of clinical and experimental medicine, 2015 Nuclear factor E2-related factor 2 (Nrf2) plays a part in antioxidant and phase II detoxification enzymes in cells by the up regulation of many antioxidant response elements (ARE) related gene transcription. Nrf2 not only protect the normal cells, but also can protect cancer cells from the effect of cell stress, which is helpful to the survival of ...
Jie, Bao +3 more
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Retraction: Low and High Dose UVB Regulation of Transcription Factor NF-E2-Related Factor 2 [PDF]
Cancer Research, 2018 [This article][1] ([1][2]) has been retracted at the request of the editors. Following an institutional investigation by the University of Maryland, Baltimore (Baltimore, MD), it was determined that the Western blot bands labeled “LaminB” and “LDH” in Figs. 2A and D have been falsified.
Sankaranarayanan, Kannan +1 more
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