Seven in absentia homolog 2 (Siah2) protein is a regulator of NF-E2-related factor 2 (Nrf2). [PDF]
J Biol Chem, 2013 Under pathological conditions such as ischemia-reperfusion, Nrf2 acts as a key regulator of cellular oxidative response. Provided that Nrf2 is sensitive to hypoxia during ischemia, Nrf2 may affect reactive oxygen species metabolism during reoxygenation.
Baba K, Morimoto H, Imaoka S.
europepmc +4 more sources
Acceleration of heat shock-induced collagen breakdown in human dermal fibroblasts with knockdown of NF-E2-related factor 2. [PDF]
BMB Rep, 2015 Heat shock increases skin temperature during sun exposure and some evidence indicates that it may be involved in skin aging. The antioxidant response mediated by the transcription factor NF-E2-related factor 2 (Nrf2) is a critically important cellular defense mechanism that serves to limit skin aging.
Park G, Oh MS.
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Correlation between expression of NF-E2-related factor 2 and progression of gastric cancer.
Int J Clin Exp Med, 2015 Nuclear factor E2-related factor 2 (Nrf2) plays a part in antioxidant and phase II detoxification enzymes in cells by the up regulation of many antioxidant response elements (ARE) related gene transcription. Nrf2 not only protect the normal cells, but also can protect cancer cells from the effect of cell stress, which is helpful to the survival of ...
Bao J, Li J, Li D, Li Z.
europepmc +2 more sources
The Protective Effect of Sulforaphane against Oxidative Stress through Activation of NRF2/ARE Pathway in Human Granulosa Cells [PDF]
Cell Journal, 2021 Objective: Sulforaphane (SFN) is a natural free radical scavenger that can reduce oxidative stress (OS) through mediating nuclear factor (erythroid-derived 2)-like 2 (NF-E2-related factor 2 or NRF2)/antioxidant response element (ARE) signaling pathway ...
Sahar Esfandyari +7 more
doaj +1 more source
The nuclear factor E2-related factor 2 and age-related macular degeneration [PDF]
, 2022 After the discovery of anti-vascular endothelial growth factor agents as treatment of wet age-related macular degeneration, the number of studies with the objective to understand the molecular mechanisms involved in the age-re lated macular degeneration ...
Ana Lúcia dos Anjos Ferreira (12684654) +3 more
core +1 more source
The nuclear factor E2-related factor 2 and age-related macular degeneration [PDF]
, 2023 After the discovery of anti-vascular endothelial growth factor agents as treatment of wet age-related macular degeneration, the number of studies with the objective to understand the molecular mechanisms involved in the age-re lated macular degeneration ...
Ana Lúcia dos Anjos Ferreira (12684654) +3 more
core +1 more source
Changes of renal histopathology and the role of Nrf2/HO-1 in asphyxial cardiac arrest model in rats
Acta Cirúrgica Brasileira, 2021 Purpose To investigate the role of Nrf2/HO-1 in renal histopathological ailments time-dependently in asphyxial cardiac arrest (CA) rat model. Methods Eighty-eight Sprague Dawley male rats were divided into five groups of eight rats each.
Ali Jawad +11 more
doaj +1 more source
Age-Related Changes in Nuclear Factor Erythroid 2-Related Factor 2 and Reactive Oxygen Species and Mitochondrial Structure in the Tongues of Fischer 344 Rats [PDF]
Clinical and Experimental Otorhinolaryngology, 2017 Objectives Previously the authors reported age-related changes in the activities of anti-oxidative enzyme activities and protein expressions in the tongues of rats.
Min-Kwan Baek +7 more
doaj +1 more source
Retraction: Low and High Dose UVB Regulation of Transcription Factor NF-E2-Related Factor 2 [PDF]
Cancer Research, 2018 [This article][1] ([1][2]) has been retracted at the request of the editors. Following an institutional investigation by the University of Maryland, Baltimore (Baltimore, MD), it was determined that the Western blot bands labeled “LaminB” and “LDH” in Figs. 2A and D have been falsified.
Sankaranarayanan, Kannan +1 more
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Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]
, 2012 Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A. +6 more
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