Results 11 to 20 of about 34,567,041 (234)

Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]

, 2012
Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A., Fiebich, Bernd L., Aderogba, Mutalib A., Okorji, Uchechukwu P., Okorji, U. P., Fiebich, B.L., Olajide, Olumayokun A.   +6 more
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The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway. [PDF]

, 1998
The X gene product of the human hepatitis B virus (HBx) is a transcriptional activator of various viral and cellular genes. We recently have determined that the production of tumor necrosis factor-alpha (TNF-alpha) by HBV-infected hepatocytes is ...
Armesilla, Angel, Redondo, Juan Miguel, Lara-Pezzi, Enrique, Juan Miguel Redondo, López-Cabrera, Manuel, Pedro L. Majano, Armesilla, Angel L., Enrique Lara-Pezzi, Angel Luis Armesilla, Majano, Pedro L., Manuel López-Cabrera, Redondo, Juan M.   +11 more
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Phosphorylation-dependent SUMOylation of the transcription factor NF-E2. [PDF]

, 2012
Nuclear factor erythroid-derived 2 (NF-E2), a heterodimer composed of p45 and p18, is a transcriptional activator in hematopoietic progenitors. The transcriptional activity of NF-E2 is not only upregulated by SUMOylation but also stimulated by the cAMP ...
Che-Kun James Shen, Yee-Fun Su, Yu-Chiau Shyu, Jaulang Hwang   +3 more
core   +1 more source

Expression of Nuclear Factor Erythroid 2 Protein in Malignant Cutaneous Tumors

Archives of Plastic Surgery, 2014
Background Reactive oxygen species (ROS) damages cell molecules, and modifies cell signaling. The nuclear factor E2-related factor (Nrf2) is a critical transcription regulator, which protects cells against oxidative damage.
Chang Yong Choi, Jin Young Kim, Seo Yeong Wee, Jang Hyun Lee, Doo Hyun Nam, Chul Han Kim, Moon Kyun Cho, Yoon Jin Lee, Hae Seon Nam, Sang Han Lee, Sung Woo Cho   +10 more
doaj   +1 more source

Standardized extract of Centella asiatica ECa 233 inhibits lipopolysaccharide-induced cytokine release in skin keratinocytes by suppressing ERK1/2 pathways

Asian Pacific Journal of Tropical Biomedicine, 2020
Objective: To evaluate the effect of standardized extract of Centella asiatica ECa 233 on inflammatory mediator production through cyclooxygenase-2 (COX-2), extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor-κB (NF-κB) pathway in ...
Furoida Moolsap, Supita Tanasawet, Mayuree H Tantisira, Pilaiwanwadee Hutamekalin, Varomyalin Tipmanee, Wanida Sukketsiri   +5 more
doaj   +1 more source

NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes [PDF]

, 2011
NF-κB is involved in immune responses, inflammation, oncogenesis, cell proliferation and apoptosis. Even though NF-κB can be activated by DNA damage via Ataxia telangiectasia-mutated (ATM) signalling, little was known about an involvement in DNA repair ...
Salles, Daniela, Bernd Baumann, Lisa Wiesmüller, Volcic, Meta, Fulda, Simone, Meta Volcic, Volcic, M., Wiesmueller, L., Baumann, B., Daniel, P., Sabine Karl, Simone Fulda, Daniela Salles, Peter Daniel, Karl, Sabine, Baumann, Bernd, Fulda, S., Salles, D., Karl, S., Daniel, Peter, Wiesmüller, Lisa   +20 more
core   +1 more source

Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling. [PDF]

PLoS ONE, 2012
TGF-β plays a key role in the development of renal fibrosis. Suppressing the TGF-β signaling pathway is a possible therapeutic approach for preventing this disease, and reports have suggested that Nrf2 protects against renal fibrosis by inhibiting TGF-β ...
Chang Joo Oh, Joon-Young Kim, Young-Keun Choi, Han-Jong Kim, Ji-Yun Jeong, Kwi-Hyun Bae, Keun-Gyu Park, In-Kyu Lee   +7 more
doaj   +1 more source

Methylcobalamin Protects Melanocytes from H2O2-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway

Drug Design, Development and Therapy, 2021
Ran An,1,2 Dong Li,1 Yingying Dong,1 Qiuyun She,1 Ting Zhou,1 Xiaoqi Nie,1 Ronghua Pan,1 Yunhua Deng1 1Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of ...
An R, Li D, Dong Y, She Q, Zhou T, Nie X, Pan R, Deng Y   +7 more
doaj  

Annexin A5 Protects SH-SY5Y Cells against L-Glutamate-Induced Cytotoxicity [PDF]

Iranian Journal of Medical Sciences
Background: L- glutamate- induced neurotoxicity is linked to neuronal loss in neurodegenerative diseases and stroke. Annexin A5 (ANXA5) is a cytosolic protein that binds calcium in eukaryotic organisms. This study aimed to evaluate the protective effects
Zahra Abedini, Marzieh Mehdieh, Mohammad Ali Takhshid   +2 more
doaj   +1 more source

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes, but not with insulin resistance [PDF]

, 2014
Mice lacking transcription factor NF-E2 p45-related factor 2 (Nrf2) develop more severe non-alcoholic steatohepatitis (NASH), with cirrhosis, than wild-type (Nrf2(+/+)) mice when fed a high-fat (HF) diet for 24 weeks.
Chowdhry, Sudhir, McCrimmon, Rory J.; id_orcid, Meakin, Paul J.; id_orcid, Dinkova-Kostova, AT, Meakin, PJ, Ashford, FB, Walsh, Shaun V., Chowdhry, S, Sharma, Ritu S., Walsh, SV, Ashford, Fiona B., Sharma, RS, Dillon, JF, Dillon, John F.; id_orcid, Hayes, John D, Hayes, JD, Dinkova-Kostova, Albena T.; id_orcid, Ashford, MLJ, Ashford, Michael L. J.; id_orcid, McCrimmon, RJ   +19 more
core   +1 more source